Topic 3 holistic approach to eating handout 1
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APOE Gene Diet is a registered trademark that provides information on different APOE gene variants and their associated risks for cardiovascular disease. It recommends gene-specific diets and lifestyles to support a healthy Gene Supportive Environment for each variant. The document outlines the different variants, their prevalence in the population, toxic clearance levels, and optimal diets, exercise, supplements and alcohol consumption based on the scientific literature to maintain cardiovascular health for each gene type. It cautions that statistics may not apply to individuals, who should work with their practitioner to determine their unique needs.
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Topic 3 holistic approach to eating handout 1
- 1. APOE Gene Diet is a registered trademark of Penscott Management Corporation. ©2009 Penscott Management Corporation.All rights reserved. APO E Gene Diet Gene Supportive Environment (GSE) APO E 2 APO E 3 APO E 4 Genotype 2/2 2/3 3/3 4/2 4/3 4/4 Incidence Of Gene Expression 1% 10% 60% 2% 20-22% 5-7% Genetic Base Pairs 112 and 158 TGC/TGC (Cys/Cys) TGC/TGC (Cys/Cys) TGC/TGC (Cys/Cys) TGC/CGC (Cys/Arg) TGC/CGC (Cys/Arg) TGC/CGC (Cys/Arg) CGC/CGC (Arg/Arg) TGC/TGC (Cys/Cys) CGC/CGC (Arg/Arg) TGC/CGC (Cys/Arg) CGC/CGC (Arg/Arg) CGC/CGC (Arg/Arg) Toxic Clearance Very High Clearance Moderately High Clearance Moderate Clearance Moderate Clearance Poor Clearance Very Poor Clearance Gene Supportive Environment (GSE) Diet Very High Fat No Processed Carbohydrate High Fat No Processed Carbohydrate Moderate Fat Moderate Fat Strict Limitations Low Fat Strict Limitations Vegetarian Strict Fat Limitations Alcohol Benefit with normal triglycerides—has been shown to increase HDL Increases LDL Strong recommendation to avoid All Alcohol Increases LDL and decreases HDL High Fiber Diet Whole Soy Food Plant Sterols (e.g. Avocado) Optimal servings of these foods reduce LDL cholesterol in all genotypes Omega 3 Supplement Decreases triglycerides, small dense LDL and increases HDL Decreases triglycerides, small dense LDL and increases HDL Decreases triglycerides, small dense LDL. Increases LDL and decreases HDL Exercise maintains a Gene Supportive Environment (GSE)* 55% Aerobic 45% Anaerobic 55% Aerobic 45% Anaerobic 50% Aerobic 50% Anaerobic 50% Aerobic 50% Anaerobic 75% Aerobic 25% Anaerobic 75% Aerobic 25% Anaerobic *Do not exercise unless you have eaten. 1. Brown AJ, Roberts DC.Arteriosclerosis Thrombosis. 1991;11:1737-1744. 2. Corder EH, Saunders AM, Strittmatter WJ, et al. 1993;261:921-923. 3. Lehtinen S, Lehtimaki T, Sisto T, et al..Atherosclerosis. 1995;114: 4. Davignon J.Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):267-9. 5. Atherosclerosis. 2006 Sep;188(1):126-33. Epub 2006 Jul 13. 6. The American Society for Nutritional Sciences J. Nutr. 134:2517-2522, October 2004 7. Krauss R M (2001) J Nutr 131:340S-3S) 8. Hudgins L C (2000) Proc Soc Exp Biol Med 225:178-83. 9. Curr Opin Lipidol. 1990;1:87-95. 10.Superko HR, Haskell WL. 1991:18:315-325. 11.Minihane AM, Khan S, Leigh-Firbank EC, et al.Arterioscler Thromb Vasc Biol. 2000;20:1990-1997. 12.Krauss R. JAMA 2002;287:712-713. 13.Am J Clinical Nutrition 2003;77:1098-111 14.Atherosclerosis. 2004 : March 173(1):79-87 15. Eur J Clin Invest. 2002 Apr;32(4):242-50. 16. J Nutr. 2009 Jan;139(1):13-9. Epub 2008 Dec 3. 17. J Nutr Biochem. 2007 Jun;18(6):418-24. Epub 2006 Oct 17. Research information and patient uniqueness: - Note to patient - Statistics never applies to the individual.The information presented here is based on clinical research - however research does not always apply to the individual. Consider your own situation, work with your medical practictioner and formulate your optimal dietary intake — each situation is unique.