TrEMBL
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TrEMBL is a computer-annotated protein sequence database created by Rolf Apweiler that contains translations of coding sequences from nucleotide databases like EMBL and GenBank as well as protein sequences from literature or submitted directly. The database provides automated classification and annotation to enrich the protein sequences.
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The document discusses several protein sequence databases including Swiss-Prot, GenPept/TREMBL, PIR, PDB, and MMDB. It provides details on Swiss-Prot, describing it as a manually curated database that distinguishes itself from others through annotations, minimal redundancy, and integration with other databases. The annotations in Swiss-Prot include core data as well as additional details on the protein's function, modifications, domains, structure, and relationships to other proteins and diseases.PIR- Protein Information Resource
PIR- Protein Information ResourceThapar Institute of Engineering & Technology, Patiala, Punjab, India
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An integrated publicly accessible bioinformatics resource to support genomic/proteomic research and scientific discovery.
Established in 1984, by the National Biomedical Research Foundation (NBRF) Georgetown University Medial Center, Washington D.C., USA.
It is the source of annotated protein databases and analysis tools for the researchers.
Serve as primary resource for the exploration of protein information.
Accessible by text search for entry and list retrieval, and also BLAST search and peptide match.
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- TrEMBL which supplements Swiss-Prot with automatically annotated translations of DNA sequences.
Protein databases are important for comparing proteins, understanding relationships between proteins, and aiding the study of new proteins. Searching databases is often the first step in protein research.Protein database
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Bioinformatics is the application of Information technology to store, organize and analyze the vast amount of biological data which is available in the form of sequences and structures of proteins and nucleic acids. The biological information of nucleic acids is available as sequences while the data of proteins is available as sequences and structures.
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Introduction
Biological database
Types: 1.primary database
Nucleic acid sequence database : Genebank , EMBL, DDJB
Protein sequence database:PIR,SWISS-PROT,TrEMBL
2. Secondary database
PRINTS
PROSITE
PROFILES
BLOCKS
IDENTITY
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Non-redundant protein sequence databases (OWL)
SWISS-PROT+ TrEMBL
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This document provides an overview of several important protein databases:
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NEED FOR DATABASE
TYPES OF DATABASE
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GENE BANK SUBMISSION TOOL
GENE BANK SUBMISSION TYPE
HOW TO RETRIEVE DATA FROM GENEBANK
APPLICATION
CONCLUSION
REFERENCE
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NEED FOR DATABASE
TYPES OF DATABASE
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NUCLEIC ACID SEQUENCE DATABASE
GENE BANK
INTRODUCTION
GENE BANK SUBMISSION TOOL
GENE BANK SUBMISSION TYPE
HOW TO RETRIEVE DATA FROM GENEBANK
APPLICATION
CONCLUSION
REFERENCE
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TrEMBL
- 4. TREMBL : A INTRODUCTION founder : Rolf Apweiler. Secondary database. TrEMBL is a computer-annotated protein sequence database. UniProtKB/TrEMBL contains the translations of all coding sequences (CDS) present in the EMBL/GenBank/DDBJ Nucleotide Sequence Databases and also protein sequences extracted from the literature or submitted to UniProtKB/Swiss- Prot. The database is enriched with automated classification and annotation. .