Trends Report on Changes in the Designer Drug Market: Spring 2012
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The document summarizes trends in designer drugs from 2010 to 2012. It discusses synthetic cannabinoids like JWH-018, AM-2201, and UR-144, as well as "bath salts" containing substances like MDPV, mephedrone, and methylone. It provides information on the prevalence, legal status, and metabolites of these drugs. It also describes efforts by the forensic community to develop standardized methods for evaluating new analogs.
![Legal Status - Federal
Temporary Scheduling
3/1/2011 Synthetic Cannabinoids
JWH-018
JWH-073
JWH-200
CP47,497 (C7)
CP47,497 (C8)
Extended 2/29/2012 8/29/2012
Federal Register Volume 77, Number 40 (Wednesday, February 29, 2012)]](https://image.slidesharecdn.com/designerdrugspringupdatebklwebinarmay2012-120525134751-phpapp02/85/Trends-Report-on-Changes-in-the-Designer-Drug-Market-Spring-2012-13-320.jpg)
Trends Report on Changes in the Designer Drug Market: Spring 2012
- 1. NMS Labs Trends Report : Changes in the Designer Drug Market Spring 2012 Barr y K Logan PhD, DABFT National Director Forensic Ser vices Willow Grove PA
- 2. Synthetic Cannabinoids - CA
- 3. Bath Salts VA
- 4. Synthetic Cannabinoids - NJ
- 5. Bath Salts - NY
- 6. Synthetic Cannabinoids - MI They broke into the garage as the family slept and stole a credit card that belonged to Cipriano's father from a car, reports say. Cipriano used the card to buy Spice -- synthetic marijuana -- and smoked it, reports say. Later that night, desperate for more money, he told a friend he needed to smoke even more Spice so he didn't have second thoughts about killing his family, according to the records.
- 7. Bath Salts - ME
- 8. Bath Salts IN
- 9. Designer Drugs Trends Trends Legal Status Novel Compounds and Drug Classes 2012 Outlook
- 11. K2/Spice What is K2/Spice? Synthetic chemicals that look to the brain like marijuana. Sprayed onto plant material for smoking. Give marijuana-like high Sold online and in head- shops Legal grey area
- 12. Chemicals - Prevalence JWH-018
- 13. Legal Status - Federal Temporary Scheduling 3/1/2011 Synthetic Cannabinoids JWH-018 JWH-073 JWH-200 CP47,497 (C7) CP47,497 (C8) Extended 2/29/2012 8/29/2012 Federal Register Volume 77, Number 40 (Wednesday, February 29, 2012)]
- 14. Chemicals - Prevalence JWH-081
- 15. Chemicals - Prevalence JWH-122
- 16. Chemicals - Prevalence AM-2201
- 17. Chemicals - Prevalence JWH-022
- 18. Chemicals - Prevalence JWH-210
- 19. Chemicals - Prevalence XLR-11 UR-144
- 20. Chemicals - Summary JWH-018/073 arrived early and have come and gone. JWH-250 arrived a little later and as also cycled out. JWH-081 was part of a second wave that has already completed its cycle. JWH-122 was part of the same wave but has persisted in popularity and is part of the current scene. AM-2201 was part of the same second wave and has gained in popularity, probably currently the most prevalent. JWH-022 and JWH-210 are showing signs of increasing popularity. Recently emergent drugs are the adamantoyl (AM-1248) and tetramethylcyclopropyl (XLR-11 and UR-144) indoles which are ahead of the latest attempts to schedule these drug classes.
- 21. Chemicals Prevalence 2010 July December 2010
- 22. Chemicals Prevalence 2012 Oct 2011 April 2012
- 23. Synthetic Cannabinoid 2010 JWH-018 JWH-019 JWH-073 CP 47, 497 (C7) CP 47,497 (C8) WIN 48,098 HU-210 HU-211
- 24. Synthetic Cannabinoid 2011 JWH-007 CP 47, 497 (C7) HU-210 JWH-015 CP 47,497 (C8) HU-211 JWH-018 CP 55,940 HU-308 JWH-018 methyl hexyl homolog AM-694 HU-331 JWH-019 AM-1220 JT-7770 JWH-073 AM-1241 JWH-073 methyl butyl homolog AM-2201 JWH-081 AM-2233 JWH-122 RCS-4 JWH-133 RCS-8 JWH-175 WIN 48,098 (Pravadoline) JWH-200 WIN 55,212-2 JWH-201 WIN 55,212-3 JWH-203 CB-25 JWH-210 CB-52 JWH-250 JWH-251 JWH-302 JWH-398
- 25. Synthetic Cannabinoid 2012 AM-694 JWH-018 Chloropentyl analog JWH-251 AM-1220 JWH-018 6-Methoxyindole analog JWH-302 AM-1241 JWH-018 1-Methylhexyl homolog JWH-307 AM-1248 JWH-019 JWH-398 AM-2201 JWH-020 RCS-4 AM-2233 JWH-022 RCS-8 CB-13 JWH-072 RCS-8 4-Methoxy CB-25 JWH-073 UR-144 CB-52 JWH-073 3-Methylbutyl homolog URB-447 CP47,497 (C7 analog) JWH-081 URB-597 CP47,497 (C8 analog) JWH-098 URB- 602 CP55,940 JWH-122 URB-754 HU-210/HU-211 JWH-133 URB-937 HU-308 JWH-147 WIN48,098 HU-331 JWH-175 (Pravadoline) JP-104 JWH-200 WIN55,212-2 JTE-907 JWH-201 WIN55,212-3 JWH-007 JWH-203 XLR-11 JWH-015 JWH-210 JWH-018 JWH-250
- 27. Designer Stimulants AKA: Bath Bubbles Bath Salts Pond Cleaner Soft Drink Additive Burial Powder Glass Cleaner Plant Food Plant Vitamin Insecticide
- 28. Legal Status - Federal Temporary Scheduling 10/21/2011 Bath Salts MDPV Mephedrone Methylone
- 30. Designer Stimulants Others include Tryptamines 5-MeO-DALT 5-MeO-DIPT 5-MeO-DMT DMT ﾎ-keto-Amphetamines Pentedrone Buphedrone Mephedrone Ethylone Pentylone Butylone 2C (Shulgin) series
- 31. Bath Salts/Designer Stimulants DMAA AMT MDEA 2C-B BDB MDMA 2C-B-FLY Bromo-DragonFLY Methedrone 2C-C Buphedrone MDPV 2C-E Butylone Mephedrone 2C-H BZP Methcathinone 2C-I Cathinone Methylone 2C-N DBZP Mitragynine 2C-P DET Naphyrone 2C-T-2 DMA O-Desmethyltramadol 2C-T-4 DMMC Pentylone 2C-T-7 DMT Phenazepam 3-FMC DOB PMA Flephedrone DOM Pyrovalerone 4-MEC Ethylone Salvinorin A/B 5-MeO-DALT MBDB TFMPP 5-MeO-DiPT MBZP 5-MeO-DMT mCPP Plus Other Traditional MDA DoA
- 32. LEGAL STATUS
- 33. Designer Drugs Trends Is It Federally Scheduled? Is It State Scheduled? Is It a Federal Analog? Is It a State Analog? Federal Analog Test: Is it substantially State Analog Test (varies): chemically similar? Is it substantially chemically Does it have equivalent similar? pharmacological activity? Does it have equivalent Is it intended for human pharmacological activity? consumption? Is it intended for human consumption?
- 34. PA State Analog Law Pennsylvania: 35 P.S. 則780-102; Designer drug means a substance other than a controlled substance that is intended for human consumption and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II or III of this act or that produces an effect substantially similar to that of a controlled substance in Schedules I, II or III. Examples of chemical classes in which designer drugs are found include, but are not limited to, the following: Phenethylamines, N-substituted piperidines, morphinans, ecgonines, quinazolinones, substituted indoles and arylcycloalkylamines.
- 35. Congressional Action H.R. 1254: Synthetic Drug Control Act of 2011 Amends the Controlled Substances Act to add as schedule I controlled substances: (1) any material, compound, mixture, or preparation which contains cannabimimetic agents (or the salts, isomers, or salts of isomers thereof), including: any substance that is a cannabinoid receptor type 1 (CB1 receptor) Specifically: CP-47,497, JWH-018, JWH-073, JWH-019, JWH-200, JWH-250, JWH-081, JWH-122, JWH-398, AM-2201, AM-694, RCS-8, RCS-4, JWH-203. http://www.gpo.gov/fdsys/pkg/BILLS-112hr1254rfs/pdf/BILLS-112h
- 36. Congressional Action H.R. 1254: Synthetic Drug Control Act of 2011 Amends the Controlled Substances Act to add as schedule I controlled substances: (1) any material, compound, mixture, or preparation which contains cannabimimetic agents (or the salts, isomers, or salts of isomers thereof), including: any substance that is a cannabinoid receptor type 1 (CB1 receptor) Specifically: CP-47,497, JWH-018, JWH-073, JWH-019, JWH-200, JWH-250, JWH-081, JWH-122, JWH-398, AM-2201, AM-694, RCS-8, RCS-4, JWH-203. Mephedrone, MDPV, Methylone, naphyrone, flephedrone, methedrone, BkPMMA, Ethcathinone , ethylone, butylone, metamfepramone, alpha- PPP, MOPPP, MDPPP, alpha-PVP, MDAI, 3-fluoromethcathinone, MPBP, 2CE, 2CD, 2CC, 2CI, 2CT2, 2CT4, 2CH, 2CN, 2CP
- 37. Congressional Action H.R. 1254: Synthetic Drug Control Act of 2011 Includes: Any substance that is a cannabinoid receptor type 1 (CB1 receptor) agonist as demonstrated by binding studies and functional assays within any of the following structural classes: 2-(3-hydroxycyclohexyl)phenol with substitution 3-(1-naphthoyl)indole or 3-(1-naphthylmethane)indole by substitution 3-(1-naphthoyl)pyrrole by substitution ... 1-(1-naphthylmethylene)indene 3-phenylacetylindole or 3-benzoylindole by substitution
- 39. Synthetic Cannabinoids Analogs JWH-018 XLR-11 AM-1248 AM-2201 UR-144
- 40. Forensic Community Advisory Committee for the Evaluation of Controlled Substance Analogs Primary Objective: create a comprehensive, scientifically sound method for evaluating non-controlled drugs for analog status Seek community consensus and peer review of our proposed method Advise and train laboratory, law enforcement, and legal personnel in our scientific method End Goal: Create consensus thereby removing the expert v. expert scenario from the courtroom when the opinion held by each expert is solely his own
- 41. Members and Actions Currently consists of 20 chemists from federal, state, and private labs, academia and law Met at MAAFS (May 14th & 15th) to organize and strategize Aggressive timeline to have a working document prepared by AAFS in Feb 2013 (if not sooner) Workshop scheduled at ACS Meeting, Phila. August 23rd For More Information Contact: Lindsay Reinhold, MFS, F-ABC NMS Labs 215-366-1331 lindsay.reinhold@nmslabs.com
- 42. TRENDS IN BIOLOGICAL FLUIDS ANALYSIS
- 43. Synthetic Cannabinoids in Blood Kacinko SL, Xu A, Homan JW, McMullin MM, Warrington DM, Logan BK. Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Identification and Quantification of JWH-018, JWH-073, JWH-019, and JWH-250 in Human Whole Blood. J Anal Toxicol. 2011;35(7):386-93. Current Scope: AM-2201, AM-694, JWH-018, JWH-019, JWH-073, JWH-081, JWH-122, JWH-200, JWH-210, JWH-250, RCS-4, RCS-8
- 44. Blood K2/Spice - Positivity
- 45. Blood K2/Spice - Positivity
- 46. Blood K2/Spice - Positivity AM-2201
- 47. Blood K2/Spice - Positivity JWH-122
- 48. Blood K2/Spice - Positivity JWH-210
- 49. Synthetic Cannabinoids in Blood 2012 2010 2011 2012 JWH-018 AM-2201 AM-2201 JWH-073 AM-694 AM-694 JWH-019 JWH-018 JWH-018 JWH-250 JWH-019 JWH-019 JWH-073 JWH-073 JWH-081 JWH-081 JWH-122 JWH-122 JWH-175 JWH-175 JWH-200 JWH-200 JWH-210 JWH-210 JWH-250 JWH-250 RCS-4 RCS-4 RCS-8 RCS-8 UR-144 XLR-11 JWH-022 JWH-203
- 50. Urine K2/Spice - Positivity
- 51. NMS Labs SynCann I and II ELISA NMS Labs Adopts Synthetic Cannabinoids ELISA Two complementary ELISAs developed and validated. For Forensic Use Only. All ELISA screens confirmed by LCMSMS Relative to current confirmatory scope: >96% Sensitivity 100% Selectivity
- 52. NMS Labs SynCann I and II ELISA Over fifty known cross-reacting species JWH 200 JWH 250 JWH 210 JWH 250 N-(4-Hydroxypentyl) met JWH 210 N-(4-hydroxypentyl) met JWH 250 N-(5-hydroxypentyl) met JWH 210 N-(5-hydroxypentyl) met JWH-018 6-hydroxyindole met JWH 250 N-(4-Hydroxypentyl) met JWH-018 7-hydroxyindole met JWH 250 N-(5-hydroxypentyl) met JWH-073 N-butanoic acid met JWH 018 N-(5-chloropentyl) analog RCS-8 JWH-018 4-hydroxyindole met AM 2201 JWH-018 4-hydroxypentyl met AM2201 N-(4-hydroxypentyl) met JWH-018 5-hydroxyindole met AM-2233 JWH-018 6-hydroxyindole met AM-694 JWH-018 7-hydroxyindole m JWH 022 JWH-018 N-(5-hydroxypentyl) met JWH 081 JWH-018 N-pentanoic acid met JWH 081 N-(4-hydroxypentyl) met JWH 019 JWH 081 N-(5-hydroxypentyl) met JWH-019 N-(5-hydroxyhexyl) met JWH 098 JWH 073 JWH 122 JWH-073 4-hydroxyindole met JWH 122 N-(5-hydroxypentyl) met OTHERS
- 53. NMS Labs Synthetic Cannabinoids in Urine Current Effective June 18th 9562U Screen Expanded, Urine 9562U Screen Expanded, Urine (Forensic) (Forensic) LCMS/MS, confirmation by repeat ELISA screen, confirmation by LCMS/MS AM2201, JWH-018, JWH-019, AM2201, JWH-018, JWH-019, JWH-073, JWH 250 JWH-073, JWH 250, JWH 122, JWH 081, JWH 210, (RCS4) 7 Analytes 15 Analytes $95 $95
- 54. OUTLOOK F0R 2012
- 57. Designer Drug Outlook Cannabinoids More non-benzyl/naphthoyl indoles Adamantoyl Tetramethylcyclopropopyl Halogenated derivatives FAAH Inhibitors More cocktails Stimulants/Hallucinogens Benzofurans Aminoindanes DMAA
- 58. The Future
- 59. QUESTIONS
Editor's Notes
- Much greater diversity of compounds, but 8 account for 60% of all. Mepedrone (meoew Mieouw) the sentinel compound is only 1.5%. Mitragynine is the active component in Kratom. Also mixed with o-desmethyl tramadol.
- Much greater diversity of compounds, but 8 account for 60% of all. Mepedrone (meoew Mieouw) the sentinel compound is only 1.5%.
- the chemical structure of which is substantially similar to the chemical structure of a controlled substance in schedule I or II; (ii) which has a stimulant , depressant , or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II (iii) with respect to a particular person, which such person represents or intends to have a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II.
- NMS Labs, United States Postal Inspection Service, Pennsylvania State Police, Marshall University, Retired DEA, NIST, Villanova University AIT Laboratories, Montgomery County (PA) District Attorney, FDA, Auburn University, Louisiana State Police, Pennsylvania State Police Washington State Patrol, Harris County (TX) Institute of Forensic Sciences
- UR-144 XLR-11 JWH-022 JWH-203 AM-2233 AM-1248
- The cutoff calibrator for this kit is JWH 250 N-(4-hydroxypentyl) metabolite at 5 ng/mL in phosphate buffered saline.
- Effective June 18th