This document discusses statistical significance and margin of error in TRI*M studies. It addresses the following key points: 1) Statistical significance is determined by factors like sample size, sample design, population size, standard deviation, and significance level. 2) Margin of error calculations for the TRI*M Index are based on its normal distribution, infinite population, and significance levels of 95%, 90%, and 80%. 3) Standard deviations are calculated from over 17,000 TRI*M studies involving more than 15 million interviews, in order to determine appropriate error rates. It is important to keep the sample design consistent over time.