Some ABCs on using quotes in storytelling, followed by some basic rules of attribution and punctuation. Nothing fancy here -- just an overview of concepts.
The document discusses the key elements of news writing, including using leads that focus on the most important facts like who, what, why and how. It also emphasizes the importance of direct quotes that elaborate on transitions between paragraphs. The transition/quote formula is presented as an effective structure for news stories to flow from most to least important information.
This document discusses logical fallacies and provides examples of the slippery slope fallacy. It begins by outlining common core standards around evaluating arguments, claims, and evidence. It then defines the slippery slope fallacy as making an argument that one action will inevitably lead to a chain of worse outcomes without evidence. Examples are provided of both strong and weak slippery slope arguments. Students are asked to evaluate whether scenarios present slippery slope fallacies and discuss in pairs. The document concludes by asking students to write their own slippery slope argument.
The document discusses Weiner's attribution theory model for explaining reasons for success and failure. It explains the attribution process involves identifying the outcome, making a causal attribution, and experiencing emotions and expectations that influence future motivation and behavior. The model includes dimensions of locus (internal vs. external), stability (stable vs. unstable), and control (within vs. outside the performer's control). An example is given of an athlete attributing a penalty miss to low ability, an internal, stable factor outside their control, leading to decreased motivation.
The document provides tips for using quotes in news writing, including only using quotes that are brief and impactful, properly formatting attribution, and ensuring quotes are placed in the proper context. It discusses best practices for incorporating quotes such as limiting lengthy quotes and avoiding double attribution. Guidelines are offered for determining when a quote should be used versus paraphrasing to avoid nonessential quotes.
Research paper-quotations-1205750933845951-4Wendy Scruggs
油
The document provides guidance on using quotations in academic writing. It outlines several principles for integrating sources concisely and avoiding ambiguity between the writer's own words and quoted material. Quotations should be used sparingly and only when necessary to support a point. Sources must be cited immediately after being referenced to clearly attribute ideas.
The document provides guidance on using quotations in academic writing. It outlines several principles for integrating sources concisely and avoiding ambiguity between the writer's own words and quoted material. Quotations should be used sparingly and only when necessary to support a point. Sources must be cited immediately after being referenced to clearly attribute ideas.
The document provides guidance on using quotations effectively in news writing. It discusses choosing quotes that are brief yet vivid. Ten tips are given for formatting quotes, such as placing attribution after a direct quote. Quotes should be used to capture specific statements, feelings, and personality. Longer quotes should be broken up. Context must be maintained when quoting to avoid misrepresentation. Paraphrasing can help when a direct quote would be inappropriate or embarrass the source.
APA STYLE _____________ Use quotations when th.docxrossskuddershamus
油
APA STYLE _____________
Use quotations when they are brief, memorable, and so well stated that a paraphrase would reduce their impact.
Faulty:Television advertising exploded in the Fifties. Advertising agencies increased spending on television commercials from $10 million in 1948 to $2 billion in 1952 (Smith, 2004, p. 16).
Correct:Television advertising exploded in the Fifties. According to Kai Smith (2004), Advertising agencies increased spending on television commercials from $10 million in 1948 to $2 billion in 1952 (p. 16).
OrTelevision advertising exploded in the Fifties, with advertising agencies increasing spending from $10 million in 1948 to $2 billion in 1952 (Smith, 2004, p. 16).
Faulty:President Roosevelt showed signs of declining health as early as 1942. Sheridan (1954) noted, His hands trembled when writing, he complained of headaches, and he often seemed unable to follow the flow of conversation around him (pp. 34-35).
Correct:President Roosevelt showed signs of declining health as early as 1942. George Sheridan (1954), an aide to the president, noted, His hands trembled when writing, he complained of headaches, and he often seemed unable to follow the flow of conversation around him (pp. 34-35).
Original Source (The Plague by Sandra Bert, page 23):The medical community of San Francisco was overwhelmed by the sudden increase in AIDS cases in the early 1980s. Tim Watson, a physician in the Bay Area, said, It was like being hit by a tidal wave. We went home every night absolutely stunned by the influx of dying young men.
Using this source and quoting Tim Watson in your paper:Within a few years the number of AIDS cases in the Bay Area, exploded. Physicians were shocked by the rising number of patients with untreatable infections. It was like being hit by a tidal wave, one physician, Tim Watson, remembered (as cited in Bert, 2005, p. 23).
Original: article online, written February 10, 2008 by James Kirkland The governor vetoed the education bill, which had been backed by a coalition of taxpayers and unions, because it cut aid to inner city schools.
Shortened quotation using ellipsis points:Kirkland (2008) reported that the governor vetoed the education bill . . . because it cut aid to inner city schools.
According to Turner (1991), George Roosevelt [no relation to the President] left the Democratic Party in 1935, troubled by the deepening Depression (p. 30).
You are writing a paper and want to include the following quotation from the book The Audacity of Hope: Thoughts on Reclaiming the American Dream, by Barack Obama:
After all, the problems of poverty and racism, the uninsured and the unemployed, are not simply technical problems. They are rooted in societal indifference and individual callousness.
The publication date for the book was October 17, 2006. The page the quotation can be found on is page 214.
Format and cite the quotation as you would in your paper.
A quotation of forty.
This document provides guidance on using quotes effectively in essays. It advises that quotes should enhance the essay by supporting ideas, showing how ideas relate, and requiring synthesis. Quotes should be relevant to the topic and analyzed or explained. Introduce quotes and provide context. Analyze quotes rather than using them alone. Introduce sources and use proper citation format.
The document discusses different types of quotations, including direct and indirect quotations. Direct quotations use the exact words from a source, while indirect quotations report the ideas without using the exact words. Both types of quotations require citing the source. The document also provides guidance on when to quote, such as to add interest, clarity, or authority. It notes that overquoting risks losing the writer's own voice and recommends balancing quotes with paraphrases and summaries.
This document provides guidance on using quotations in academic writing. It discusses reasons for using quotations, such as to provide evidence or lend fresh perspectives. Rules for formatting quotations are outlined, such as placing punctuation inside or outside quotation marks depending on the context. The document also advises on introducing, explaining the significance of, and citing quotations used. It recommends quoting only the most concise and relevant parts of sources to primarily use one's own words in academic writing.
This presentation provides the basic understanding and guidelines in Quoting and Paraphrasing the literatures for its integration into our research papers. This will help us to avoid committing plagiarism in our work. It also provides how to quote and paraphrase information and ideas from various type of sources.
For more on this topic, see my Youtube Channel: https://youtu.be/Bq7BAtHs7gE
The document discusses different types of quotes used in academic writing, including direct quotes, which use exact wording from a source and require quotation marks, and indirect quotes, which are paraphrased and do not require quotation marks. It provides examples of integrating direct quotes into sentences and introducing them with attribution or a colon. The document also covers summarizing, paraphrasing, and properly punctuating and citing quotes based on MLA style guidelines.
A straight news story reports on a recent event within 24 hours in a factual manner without personal interpretation. It follows an inverted pyramid structure with the most important facts at the top. When writing a news story, journalists must protect themselves from libel by carefully attributing all facts and quotes to sources. Direct quotations should be used sparingly and attributed properly based on punctuation rules.
This document provides guidance on proper grammar, punctuation, and style for news writing. It addresses commonly misused words and offers rules for punctuation including commas, semicolons, colons, hyphens, dashes, apostrophes and quotation marks. The document also discusses using active voice and following Associated Press style guidelines for titles, acronyms, numbers, dates, times, and titles of creative works.
The document provides style guidelines for writing quotes and attribution in news stories. It recommends using direct quotes to add voice and credibility but to paraphrase mundane information. Quotes should be used selectively to highlight memorable statements. Guidance is given on punctuation for quotes, introducing speakers, continuing lengthy quotes across paragraphs, and referencing speakers on subsequent mentions. Number style, date formatting, capitalization rules, and sentence structure tips are also outlined.
This document provides guidance on using quotations and attribution in writing. It outlines best practices for directly quoting sources, including accurately capturing the speaker's words and attributing quotes properly. The document also discusses indirect quotations, paraphrases, partial quotes, and dialogue. Examples are provided for different types of quotes. The document stresses never inventing quotes and always attributing opinions to sources.
The document discusses plagiarism and proper citation methods. It defines plagiarism as using another's ideas or words without credit. It can result in academic and legal consequences. Direct quotes, facts, opinions, and data from others must be cited, while common knowledge need not be. Proper use of quotes, paraphrasing, and summarizing is covered, along with the need to cite sources to avoid plagiarism.
Abridged version ap grammar and style by hanlon-nugentshuckabe
油
This is a presentation shared by Prof. Stephanie Hanlon-Nugent. I am going to share it in two presentations for a high school journalism course. It is an excellent, concise summary of key AP style and grammar points.
This document discusses proper paraphrasing, quoting, and summarizing techniques when using other authors' work. It explains that paraphrasing involves putting an author's idea into your own words and citing the source, while a quotation uses the exact words in quotation marks. A summary should contain the main points from the author in a condensed form. Examples are provided to illustrate proper paraphrasing versus plagiarism. The document also reviews when to paraphrase, quote, or summarize and covers APA formatting guidelines.
The document discusses different types of quotes that can be used in essays, including direct quotes, indirect quotes, and partial quotes. It provides guidelines for punctuating and integrating various kinds of quotes, such as using attribution tags or introducing quotes with a full sentence and colon. Block quotes of four lines or longer are indented, and quotes must always be explained and connected back to the author's thesis. Providing the source and page number for all quotes cited in the text is also reviewed.
Integrating quotations, citations, and works citedkimpalmore
油
This document provides guidance on integrating quotations, citations, and creating a works cited page according to MLA style. It covers topics such as using quotations at the beginning, middle, and end of sentences and with your own words. Rules for punctuation before and after quotations are presented. Guidance is also given on formatting block quotations, summarizing sources, citing summarized material, avoiding grammatical errors, and constructing a works cited page.
The document provides guidance on how to properly paraphrase and cite sources to avoid plagiarism. It defines plagiarism as passing off another's work as one's own and explains that any ideas or content taken from an outside source must be cited, regardless of whether it is a direct quote or paraphrased. The document outlines a three-step process for properly paraphrasing a source: reading the source, putting it into one's own words while taking notes, and citing the source. It also discusses when a direct quote is warranted and how to format both paraphrases and direct quotes with citations in papers or assignments.
Martinez 1 Quotation Integration Every time you.docxAASTHA76
油
This document provides guidance on properly integrating quotations into academic writing. It begins by stating that quotations must be signaled and explains the basic punctuation rules for introducing quotations, such as using commas with introductory phrases and colons with complete introductory sentences. The document then describes three main ways to integrate quotations: with a dependent clause and comma, with a colon and independent clause, or by making the quotation part of the writer's own sentence. It provides examples of each and notes that MLA style requires explaining quotations in the writer's own words while APA style does not. The document concludes by discussing how to avoid plagiarism when quoting and paraphrasing.
Reference Quotes. Validation of Skills: ReferenceMelissa Mack
油
The document discusses the importance of incorporating reference quotes into resumes. It explains that reference quotes can help validate a candidate's skills, demonstrate their character qualities, and make their application stand out. Several benefits of using reference quotes are outlined, including how they provide third-party validation of accomplishments and highlight traits that are valuable to employers like professionalism and integrity. Hiring managers are also more likely to form a personal connection with a candidate when reference quotes are included.
This document provides an agenda and notes for an English writing class. It covers topics like introductions, conclusions, integrating quotations, citing sources, and punctuation. For introductions, it recommends strategies like using a scenario, statistics, analogy, or previewing negative consequences. For conclusions, it suggests summarizing solutions, ending with a scenario, or making a call to action. The document provides examples and rules for integrating quotations in sentences and as block quotations. It also covers citing summarized sources and punctuating within quotations. The homework assigned is to post an introduction and conclusion, finish a draft using MLA format with works cited, and study vocabulary words.
This document provides an overview of research paper writing and the proper use of citations and references. It discusses seven key things to know: 1) using quotes, 2) paraphrasing, 3) citations, 4) references, 5) hidden codes in citations, 6) how to apply what is learned, and 7) dealing with non-original ideas. The document reviews ethics around borrowing ideas and provides examples and rules for correctly citing sources using different citation styles. It also covers punctuation conventions for references.
How to Use Owl Slots in Odoo 17 - Odoo 際際滷sCeline George
油
In this slide, we will explore Owl Slots, a powerful feature of the Odoo 17 web framework that allows us to create reusable and customizable user interfaces. We will learn how to define slots in parent components, use them in child components, and leverage their capabilities to build dynamic and flexible UIs.
New syllabus entomology (Lession plan 121).pdfArshad Shaikh
油
*Fundamentals of Entomology*
Entomology is the scientific study of insects, including their behavior, ecology, evolution, classification, and management. Insects are the most diverse group of organisms on Earth, with over a million described species. Understanding entomology is crucial for managing insect pests, conserving beneficial insects, and appreciating their role in ecosystems.
*Key Concepts:*
- Insect morphology and anatomy
- Insect physiology and behavior
- Insect ecology and evolution
- Insect classification and identification
- Insect management and conservation
Entomology has numerous applications in agriculture, conservation, public health, and environmental science, making it a vital field of study.
This document provides guidance on using quotes effectively in essays. It advises that quotes should enhance the essay by supporting ideas, showing how ideas relate, and requiring synthesis. Quotes should be relevant to the topic and analyzed or explained. Introduce quotes and provide context. Analyze quotes rather than using them alone. Introduce sources and use proper citation format.
The document discusses different types of quotations, including direct and indirect quotations. Direct quotations use the exact words from a source, while indirect quotations report the ideas without using the exact words. Both types of quotations require citing the source. The document also provides guidance on when to quote, such as to add interest, clarity, or authority. It notes that overquoting risks losing the writer's own voice and recommends balancing quotes with paraphrases and summaries.
This document provides guidance on using quotations in academic writing. It discusses reasons for using quotations, such as to provide evidence or lend fresh perspectives. Rules for formatting quotations are outlined, such as placing punctuation inside or outside quotation marks depending on the context. The document also advises on introducing, explaining the significance of, and citing quotations used. It recommends quoting only the most concise and relevant parts of sources to primarily use one's own words in academic writing.
This presentation provides the basic understanding and guidelines in Quoting and Paraphrasing the literatures for its integration into our research papers. This will help us to avoid committing plagiarism in our work. It also provides how to quote and paraphrase information and ideas from various type of sources.
For more on this topic, see my Youtube Channel: https://youtu.be/Bq7BAtHs7gE
The document discusses different types of quotes used in academic writing, including direct quotes, which use exact wording from a source and require quotation marks, and indirect quotes, which are paraphrased and do not require quotation marks. It provides examples of integrating direct quotes into sentences and introducing them with attribution or a colon. The document also covers summarizing, paraphrasing, and properly punctuating and citing quotes based on MLA style guidelines.
A straight news story reports on a recent event within 24 hours in a factual manner without personal interpretation. It follows an inverted pyramid structure with the most important facts at the top. When writing a news story, journalists must protect themselves from libel by carefully attributing all facts and quotes to sources. Direct quotations should be used sparingly and attributed properly based on punctuation rules.
This document provides guidance on proper grammar, punctuation, and style for news writing. It addresses commonly misused words and offers rules for punctuation including commas, semicolons, colons, hyphens, dashes, apostrophes and quotation marks. The document also discusses using active voice and following Associated Press style guidelines for titles, acronyms, numbers, dates, times, and titles of creative works.
The document provides style guidelines for writing quotes and attribution in news stories. It recommends using direct quotes to add voice and credibility but to paraphrase mundane information. Quotes should be used selectively to highlight memorable statements. Guidance is given on punctuation for quotes, introducing speakers, continuing lengthy quotes across paragraphs, and referencing speakers on subsequent mentions. Number style, date formatting, capitalization rules, and sentence structure tips are also outlined.
This document provides guidance on using quotations and attribution in writing. It outlines best practices for directly quoting sources, including accurately capturing the speaker's words and attributing quotes properly. The document also discusses indirect quotations, paraphrases, partial quotes, and dialogue. Examples are provided for different types of quotes. The document stresses never inventing quotes and always attributing opinions to sources.
The document discusses plagiarism and proper citation methods. It defines plagiarism as using another's ideas or words without credit. It can result in academic and legal consequences. Direct quotes, facts, opinions, and data from others must be cited, while common knowledge need not be. Proper use of quotes, paraphrasing, and summarizing is covered, along with the need to cite sources to avoid plagiarism.
Abridged version ap grammar and style by hanlon-nugentshuckabe
油
This is a presentation shared by Prof. Stephanie Hanlon-Nugent. I am going to share it in two presentations for a high school journalism course. It is an excellent, concise summary of key AP style and grammar points.
This document discusses proper paraphrasing, quoting, and summarizing techniques when using other authors' work. It explains that paraphrasing involves putting an author's idea into your own words and citing the source, while a quotation uses the exact words in quotation marks. A summary should contain the main points from the author in a condensed form. Examples are provided to illustrate proper paraphrasing versus plagiarism. The document also reviews when to paraphrase, quote, or summarize and covers APA formatting guidelines.
The document discusses different types of quotes that can be used in essays, including direct quotes, indirect quotes, and partial quotes. It provides guidelines for punctuating and integrating various kinds of quotes, such as using attribution tags or introducing quotes with a full sentence and colon. Block quotes of four lines or longer are indented, and quotes must always be explained and connected back to the author's thesis. Providing the source and page number for all quotes cited in the text is also reviewed.
Integrating quotations, citations, and works citedkimpalmore
油
This document provides guidance on integrating quotations, citations, and creating a works cited page according to MLA style. It covers topics such as using quotations at the beginning, middle, and end of sentences and with your own words. Rules for punctuation before and after quotations are presented. Guidance is also given on formatting block quotations, summarizing sources, citing summarized material, avoiding grammatical errors, and constructing a works cited page.
The document provides guidance on how to properly paraphrase and cite sources to avoid plagiarism. It defines plagiarism as passing off another's work as one's own and explains that any ideas or content taken from an outside source must be cited, regardless of whether it is a direct quote or paraphrased. The document outlines a three-step process for properly paraphrasing a source: reading the source, putting it into one's own words while taking notes, and citing the source. It also discusses when a direct quote is warranted and how to format both paraphrases and direct quotes with citations in papers or assignments.
Martinez 1 Quotation Integration Every time you.docxAASTHA76
油
This document provides guidance on properly integrating quotations into academic writing. It begins by stating that quotations must be signaled and explains the basic punctuation rules for introducing quotations, such as using commas with introductory phrases and colons with complete introductory sentences. The document then describes three main ways to integrate quotations: with a dependent clause and comma, with a colon and independent clause, or by making the quotation part of the writer's own sentence. It provides examples of each and notes that MLA style requires explaining quotations in the writer's own words while APA style does not. The document concludes by discussing how to avoid plagiarism when quoting and paraphrasing.
Reference Quotes. Validation of Skills: ReferenceMelissa Mack
油
The document discusses the importance of incorporating reference quotes into resumes. It explains that reference quotes can help validate a candidate's skills, demonstrate their character qualities, and make their application stand out. Several benefits of using reference quotes are outlined, including how they provide third-party validation of accomplishments and highlight traits that are valuable to employers like professionalism and integrity. Hiring managers are also more likely to form a personal connection with a candidate when reference quotes are included.
This document provides an agenda and notes for an English writing class. It covers topics like introductions, conclusions, integrating quotations, citing sources, and punctuation. For introductions, it recommends strategies like using a scenario, statistics, analogy, or previewing negative consequences. For conclusions, it suggests summarizing solutions, ending with a scenario, or making a call to action. The document provides examples and rules for integrating quotations in sentences and as block quotations. It also covers citing summarized sources and punctuating within quotations. The homework assigned is to post an introduction and conclusion, finish a draft using MLA format with works cited, and study vocabulary words.
This document provides an overview of research paper writing and the proper use of citations and references. It discusses seven key things to know: 1) using quotes, 2) paraphrasing, 3) citations, 4) references, 5) hidden codes in citations, 6) how to apply what is learned, and 7) dealing with non-original ideas. The document reviews ethics around borrowing ideas and provides examples and rules for correctly citing sources using different citation styles. It also covers punctuation conventions for references.
How to Use Owl Slots in Odoo 17 - Odoo 際際滷sCeline George
油
In this slide, we will explore Owl Slots, a powerful feature of the Odoo 17 web framework that allows us to create reusable and customizable user interfaces. We will learn how to define slots in parent components, use them in child components, and leverage their capabilities to build dynamic and flexible UIs.
New syllabus entomology (Lession plan 121).pdfArshad Shaikh
油
*Fundamentals of Entomology*
Entomology is the scientific study of insects, including their behavior, ecology, evolution, classification, and management. Insects are the most diverse group of organisms on Earth, with over a million described species. Understanding entomology is crucial for managing insect pests, conserving beneficial insects, and appreciating their role in ecosystems.
*Key Concepts:*
- Insect morphology and anatomy
- Insect physiology and behavior
- Insect ecology and evolution
- Insect classification and identification
- Insect management and conservation
Entomology has numerous applications in agriculture, conservation, public health, and environmental science, making it a vital field of study.
In this presentation we will show irrefutable evidence that proves the existence of Pope Joan, who became pontiff in 856 BC and died giving birth in the middle of a procession in 858 BC.
This article explores the miraculous event of the Splitting of the Moon (Shaqq al-Qamar) as recorded in Islamic scripture and tradition. Drawing from the Qur'an, authentic hadith collections, and classical tafsir, the article affirms the event as a literal miracle performed by Prophet Muhammad 鏃 in response to the Qurayshs demand for a sign. It also investigates external historical accounts, particularly the legend of Cheraman Perumal, a South Indian king who allegedly witnessed the miracle and embraced Islam. The article critically examines the authenticity and impact of such regional traditions, while also discussing the lack of parallel astronomical records and how scholars have interpreted this event across centuries. Concluding with the theological significance of the miracle, the article offers a well-rounded view of one of Islams most discussed supernatural events.
The philosophical basis of curriculum refers to the foundational beliefs and values that shape the goals, content, structure, and methods of education. Major educational philosophiesidealism, realism, pragmatism, and existentialismguide how knowledge is selected, organized, and delivered to learners. In the digital age, understanding these philosophies helps educators and content creators design curriculum materials that are purposeful, learner-centred, and adaptable for online environments. By aligning educational content with philosophical principles and presenting it through interactive and multimedia formats.
Paper 110A | Shadows and Light: Exploring Expressionism in The Cabinet of Dr...Rajdeep Bavaliya
油
Dive into the haunting worlds of German Expressionism as we unravel how shadows and light elevate The Cabinet of Dr.油Caligari and Nosferatu: A Symphony of Horror into timeless masterpieces. Discover the psychological power of chiaroscuro, distorted sets, and evocative silhouettes that shaped modern horror. Whether youre a film buff or a budding cinephile, this journey through postWWI trauma and surreal visuals will leave you seeing movies in a whole new light. Hit play, share your favorite shockandawe moment in the comments, and dont forget to follow for more deepdives into cinemas most influential movements!
M.A. Sem - 2 | Presentation
Presentation Season - 2
Paper - 110A: History of English Literature From 1900 to 2000
Submitted Date: April 1, 2025
Paper Name: History of English Literature From 1900 to 2000
Topic: Shadows and Light: Exploring Expressionism in The Cabinet of Dr.油Caligari and Nosferatu: A Symphony of Horror
[Please copy the link and paste it into any web browser to access the content.]
Video Link: https://youtu.be/pWjHqo6clT4
For a more in-depth discussion of this presentation, please visit the full blog post at the following link:
Please visit this blog to explore additional presentations from this season:
Hashtags:
#GermanExpressionism #SilentHorror #Caligari #Nosferatu #Chiaroscuro #VisualStorytelling #FilmHistory #HorrorCinema #CinematicArt #ExpressionistAesthetics
Keyword Tags:
Expressionism, The Cabinet of Dr. Caligari, Nosferatu, silent film horror, film noir origins, German Expressionist cinema, chiaroscuro techniques, cinematic shadows, psychological horror, visual aesthetics
How to Add a Custom Menu, List view and FIlters in the Customer Portal Odoo 18Celine George
油
To create a new menu in the "My Accounts" portal and set up a list/form view in Odoo 18, follow these steps. For Example- The custom menu has now been added to the "Fleet" customer portal.
"Orthoptera: Grasshoppers, Crickets, and Katydids pptxArshad Shaikh
油
Orthoptera is an order of insects that includes grasshoppers, crickets, and katydids. Characterized by their powerful hind legs, Orthoptera are known for their impressive jumping ability. With diverse species, they inhabit various environments, playing important roles in ecosystems as herbivores and prey. Their sounds, often produced through stridulation, are distinctive features of many species.
What are the Features & Functions of Odoo 18 SMS MarketingCeline George
油
A key approach to promoting a business's events, products, services, and special offers is through SMS marketing. With Odoo 18's SMS Marketing module, users can notify customers about flash sales, discounts, and limited-time offers.
This study describe how to write the Research Paper and its related issues. It also presents the major sections of Research Paper and various tools & techniques used for Polishing Research Paper
before final submission.
Finding a Right Journal and Publication Ethics are explain in brief.
Drug Metabolism advanced medicinal chemistry.pptxpharmaworld
油
This document describes about structural metabolism relationship and drug designing and toxicity of drugs in " DRUG METABOLISM"
In Drug Metabolism is the process of converting a drug into product or inert substances after or before reaching at the site of action.
Metabolism plays an important role in elimination of drugs and foreign substance from the body.
The metabolism of any drug is generally characterised by two phases of reaction
1.Metabolic transformation ( biotransformation ) and
2.Conjugation
The Principal site of drug metabolism is the liver, but the kidney, lungs, and GIT also are important metabolic sites.
The enzymatic bio transformations of drugs is known as Drug Metabolism. Because many drugs have structures similar to those of endogenous compounds , drugs may get metabolised by specific enzymes for the related natural substrates as well as by non-specific enzymes.
Reaction type of Phase-I:
1.Oxidation
2.Reduction
3.Hydrolysis
Most drugs are metabolised ,atleast to some extent , by both phases of metabolism.
Example: Metabolism of Aspirin
Acetyl Salicylic acid undergoes hydrolysis to salicylic acid ( metabolic transformation ), which is then conjugated with glycine to form Salicyluric acid ( Conjugation ).
In Phase-II the metabolites formed in Phase-II are converted to more polar and water soluble product by attaching polar and ionisable moiety such as
1.Glucuronic acid
2.Glycine
3.Glutamine
4.Glutathione conjugation
5.Acetylation
6.Methylation
7.Sulfate conjugation
8.Nucleoside and Nucleotide formation
9.Amino Acid Conjugation
10.Fatty Acid and Cholesterol Conjugation
Drug design is the process of creating new drugs by using knowledge of a biological target.
Drug design considers metabolism to optimize pharmaco kinects ( ADME: Absorption , Distribution , Metabolism , Excretion )
Cytochrome CYP450 enzyme in Drug Metabolism is vital in drug design to enhance efficacy , reduce toxicity and improve bioavailability.
Cytochrome P450 enzymes (CYPs) are a superfamily of heme -containing proteins found from bacteria to human.
Cytochrome P-450 activity in various organs like Liver,Lung ,Kidney , Intestine,Placenta
Adrenal and Skin and they shows the relative activity with repect to their organs in the process of drug metabolism.
Most important CYP450 enzymes are CYP1A2 , CYP2C9 , CYP2E1
,etc...
Toxic Effects of Drug Metabolism
Toxicity: Accumulation of Excess of medications in the Blood Stream.
Ariens (1948) and Mitchell and Horning (1984) deal with this topic.
Some examples of Metabolism-Linked Toxicity are
1.Acetaminophen (paracetmol)
2.Isoniazid ( TB drug)
3.Chloroform
4.Dapsone
5.Diazepam
6.Salicylate
7.Halothane (Anesthetic)
8.Tamoxifen (Breast Cancer drug )
9.Clozapine(Antipsychotic)
These drugs are differentiates with the TOXIC METABOLITE , TOXICITY OF METABOLITE.
References for this topic also mentioned at the end.
Understanding-the-Weather.pdf/7th class/social/ 2nd chapter/Samyans Academy n...Sandeep Swamy
油
Weather shapes our world and daily lives. This presentation explores how we measure weather conditions and use predictions to prepare for various weather events. "A change in the weather is sufficient to create the world and oneself anew." - Marcel Proust, French novelist by sandeep swamy
CURRENT CASE COUNT: 880
Texas: 729 (+5) (56% of cases are in Gaines County)
New Mexico: 78 (+4) (83% of cases are from Lea County)
Oklahoma: 17
Kansas: 56 (38.89% of the cases are from Gray County)
HOSPITALIZATIONS: 103
Texas: 94 - This accounts for 13% of all cases in the State.
New Mexico: 7 This accounts for 9.47% of all cases in New Mexico.
Kansas: 2 - This accounts for 3.7% of all cases in Kansas.
DEATHS: 3
Texas: 2 This is 0.28% of all cases
New Mexico: 1 This is 1.35% of all cases
US NATIONAL CASE COUNT: 1,076 (confirmed and suspected)
INTERNATIONAL SPREAD
Mexico: 1,753 (+198) 4 fatalities
Chihuahua, Mexico: 1,657 (+167) cases, 3 fatalities, 9 hospitalizations
Canada: 2518 (+239) (Includes Ontarios outbreak, which began November 2024)
Ontario, Canada: 1,795 (+173) 129 (+10) hospitalizations
Alberta, Canada: 560 (+55)
Things to keep an eye on:
Mexico: Three children have died this month (all linked to the Chihuahua outbreak):
An 11-month-old and a 7-year-old with underlying conditions
A 1-year-old in Sonora whose family is from Chihuahua
Canada:
Ontario now reports more cases than the entire U.S.
Albertas case count continues to climb rapidly and is quickly closing in on 600 cases.
Emerging transmission chains in Manitoba and Saskatchewan underscore the need for vigilant monitoring of under-immunized communities and potential cross-provincial spread.
United States:
North Dakota: Grand Forks County has confirmed its first cases (2), linked to international travel. The state total is 21 since May 2 (including 4 in Cass County and 2 in Williams County), with one hospitalization reported.
OUTLOOK: With the springsummer travel season peaking between Memorial Day and Labor Day, both domestic and international travel may fuel additional importations and spread. Although measles transmission is not strictly seasonal, crowded travel settings increase the risk for under-immunized individuals.
1. Using quotes This presentation includes materials and examples Ive accumulated over 20 years. Most of the materials long ago became detached from their sources. Im not claiming these ideas as my own. I simply cant trace everything back to the original documents. Bill Sledzik
2. Using quotes When source says it best Always do right. This will gratify some people and astonish the rest. Mark Twain 油 油 What this country needs is dirtier fingernails and a cleaner mind. 油 Winston Churchill
3. Using quotes To illustrate a point Most of the students we tested couldnt balance a checkbook or calculate a simple discount offer, Williamson said.
4. Using quotes To add emphasis 油 Two hundred years ago they tossed tea into Boston Harbor over this same kind of government intrusion, said Allen B. Johnson, president of the Kent Conservative Club. The time for revolution may be upon us once again.
5. Using quotes To create drama 油 油 We all felt helpless as we watched the balloon crash to the ground, Johnson said. All we had to offer was our prayers. When the car finally stopped spinning, we stepped out dizzy, but alive and well.
7. Using quotes Fluff adds empty words 油 The Jobs for Smithport program is one of the most aggressive initiatives of this administration, said County Executive Tim Daly, and its a plan that will truly enhance the quality of peoples lives. 油
8. Using quotes Substance aids understanding 油 The Jobs for Smithport program is designed to help young people select careers with long-term earning potential and to pursue those careers right here in their home town, said Summit County Executive Tim Daly. 油
9. Using quotes Fluff adds empty words In Jones County, we hold our officials to a standard of total integrity and honesty. We cant tolerate anything short of absolute commitment to public service, Daly said.
10. Using quotes Substance aids understanding Were no longer going tolerate people who seduce public officials with bribes, then call those bribes legitimate campaign contributions, Daly said. We intend to prosecute each and every one of them.
11. 7 Rules for Attribution Use said when attributing to a person for direct and indirect quotes. Use according to when citing factual info from a non-personal source . Use attribution mid-sentence only at a natural break (between phrases, clauses, or sentences). We tried to negotiate a compromise, Allen said, but the union wasnt interested.
12. 7 Rules for Attribution 4. Attribute statements like hope or believe. 油 NO: He believes the team will win tomorrow. YES: He said he believes the team will win tomorrow.
13. 7 Rules for Attribution 5. Attribute early Dont present 2-3 sentences of quotes and leave the reader wondering who is speaking. Attribute in the first sentence.
14. 7 Rules for Attribution 6. But dont attribute up front (for print media) Lefton said, Well do whatever it takes to protect the interests of students. Instead: Well do whatever it takes to protect the interests of our students, Lefton said.
15. 7 Rules for Attribution 7. Edit redundancies 油 Jones said she was surprised to be chosen for the writing award. I was so surprised when they called my name, she said. Instead: Jones said she was surprised to win the writing award. When they called my name, I couldnt move. I felt glued to my seat.
16. 9 Guidelines for Caps & Punctuation 1. The first word in a quotation that is a complete sentence is capitalized, but the first word in partial quotation is not capitalized. 油 He said, Life is just one darned thing after another. He called journalism history in a hurry.
17. 9 Guidelines for Caps & Punctuation 2. When attribution is placed before a quotation that contains one full sentence , the attribution should be followed by a comma. If the sentence contains two or more sentences, the attribution should be followed by a colon. 油 James Thurber said, It is better to know some of the questions than all of the answers. Mark Twain said: I apologize for writing a long letter. If Id had more time, Id have written a shorter one.
18. 9 Guidelines for Caps & Punctuation 3. When you place attribution after a quote, use a comma (not a period) after the last word in the quotation. 油 He was trying to help somebody, his wife said.
19. 9 Guidelines for Caps & Punctuation 4. Place the comma or period at the end of a sentence inside the quotation marks . No exceptions 油 Benjamin Franklin said, A penny saved is a penny earned.
20. 9 Guidelines for Caps & Punctuation 5. Place words of attribution in their normal order, with the subject appearing before the verb. 油 Ive noticed that everybody whos for abortion has already been born, Ronald Reagan said.
21. 9 Guidelines for Caps & Punctuation 6. Only the quotationnever the attributionshould be placed inside the quotation marks. 油 The motorcycle slid sideways and skidded about 100 feet, she said . The driver was killed.
22. 9 Guidelines for Caps & Punctuation 7. If a quotation continues for several sentences, all the sentences should be enclosed within a single set of quotation marks; quotation marks dont have to be placed at the beginning and the end of every sentence. 油 The report said: The land is too expensive. Its price doubled in five years.
23. 9 Guidelines for Caps & Punctuation 8. Divide long quotations into paragraphs, but only at natural breaksusually changes in topic, however slight. Place quotation marks at the beginning of a long quotation and at the beginning of every new paragraph. Place closing quotes only at the end of the quotation not at the end of each paragraph.
24. 9 Guidelines for Caps & Punctuation The senator added: Perhaps the most shocking example of the insensitivity of the Bureau of Indian Affairs is the manner in which boarding school dormitories have been administered. 油 Psychiatrists familiar with the problems of Indian children have told us that a properly run dormitory is the most crucial aspect of boarding school, particularly at the elementary levels. Yet, when a 6-year-old Navajo child enters one of the boarding schools and becomes lonely or homesick, he must seek comfort from an instructional aid who has no training in child guidance and who is responsible for as many as 100 other unhappy children.
25. 9 Guidelines for Caps & Punctuation 9. When a quotation is enclosed in another quotation, the first is enclosed in double quotation marks, the second in single quotation marks. 油 My breathing was shallow, my heartbeat weak and my pulse faint Bean said. Thats when the doctor told my husband, I think she may die.