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Vinca alkaloids

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Navreet Saini

This document discusses the properties and uses of vinca alkaloids, a class of anti-mitotic and anti-microtubule agents that includes vincristine, vinblastine, vinorelbine, and vindesine. They are cell-cycle specific cytotoxic agents used in combination chemotherapy to treat lymphomas, breast cancer, and testicular carcinoma. They work by binding to mitotic spindle proteins and causing metaphase arrest. Side effects include neurotoxicity, nausea, vomiting, alopecia, and myelosuppression.

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Vinca alkaloids
Anti-mitotic and anti-microtubule alkaloid agent. Cell- cycle specific cytotoxic agents Produced synthetically.
Vinca alkaloids
Vinca alkaloids
Vinca alkaloids
Vinca alkaloids
Vincristine Vinblastine Vinorelbine Vindesine
INDICATIONS - Combination chemotherapy of 1. Lymphomas ( HL , NHL) 2. Advanced breast cancer 3. Non- seminomatous testicular carcinoma
Cell cycle specific M phase action, binds to proteins of mitotic spindle causing metaphase arrest. Specific action- Inhibits angiogenesis
1. Death of rapidly replicating malignant cells. 2. Has immunosuppressive properties.
CNS- Seizures, neurotoxicity, depression RESP- Bronchospasm GI- Nausea, Vomiting, Anorexia, Constipation DERM- Alopecia ENDO- SIADH HEMAT- Anemia, Leukopenia,Thrombocyopenia LOCAL- Phlebitis at IV site METAB- Hyperuricemia NEURO- Neuritis, peripheral neuropathy
1mg/ml in 10 ml vial
Onset- 5-7 Days Peak- 10 days Duration- 7-14 Day
NURSING IMPLICATIONS
Indications- used alone or in combination with 1. HL 2. Leukemias 3. Neuroblastoma 4. Malignant melanoma 5. Rhabdomyosarcoma 6. Wilms tumour
1. CNS- Insomnia, Depression 2. EENT- Diplopia, Cortical blindness 3. RESP- Bronchospasm 4. GI- Nausea, Vomiting, Abdominal cramps, Anorexia, Constipation, Stomatitis 5. GU-Gonadal suppression, Nocturia, Oliguria, Urinary retention 6. Derm- Alopecia 7. Endo- SIADH 8. Hemat- Anemia, Leukopenia, Thrombocytopenia 9. Local- Phlebitis at IV site 10. Neuro- Ascending peripheral neurapathy
1mg/ml in 1-25 ml vials
ONSET- unknown PEAK- 4 days DURATION- 7 days
NURSING IMPLICATIONS
Vinca alkaloids

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Vinca alkaloids

  • 2. Anti-mitotic and anti-microtubule alkaloid agent. Cell- cycle specific cytotoxic agents Produced synthetically.
  • 7. Vincristine Vinblastine Vinorelbine Vindesine
  • 8. INDICATIONS - Combination chemotherapy of 1. Lymphomas ( HL , NHL) 2. Advanced breast cancer 3. Non- seminomatous testicular carcinoma
  • 9. Cell cycle specific M phase action, binds to proteins of mitotic spindle causing metaphase arrest. Specific action- Inhibits angiogenesis
  • 10. 1. Death of rapidly replicating malignant cells. 2. Has immunosuppressive properties.
  • 11. CNS- Seizures, neurotoxicity, depression RESP- Bronchospasm GI- Nausea, Vomiting, Anorexia, Constipation DERM- Alopecia ENDO- SIADH HEMAT- Anemia, Leukopenia,Thrombocyopenia LOCAL- Phlebitis at IV site METAB- Hyperuricemia NEURO- Neuritis, peripheral neuropathy
  • 12. 1mg/ml in 10 ml vial
  • 13. Onset- 5-7 Days Peak- 10 days Duration- 7-14 Day
  • 15. Indications- used alone or in combination with 1. HL 2. Leukemias 3. Neuroblastoma 4. Malignant melanoma 5. Rhabdomyosarcoma 6. Wilms tumour
  • 16. 1. CNS- Insomnia, Depression 2. EENT- Diplopia, Cortical blindness 3. RESP- Bronchospasm 4. GI- Nausea, Vomiting, Abdominal cramps, Anorexia, Constipation, Stomatitis 5. GU-Gonadal suppression, Nocturia, Oliguria, Urinary retention 6. Derm- Alopecia 7. Endo- SIADH 8. Hemat- Anemia, Leukopenia, Thrombocytopenia 9. Local- Phlebitis at IV site 10. Neuro- Ascending peripheral neurapathy
  • 17. 1mg/ml in 1-25 ml vials
  • 18. ONSET- unknown PEAK- 4 days DURATION- 7 days