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Vitamin d presentation

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Brett Eaker

Vitamin D is a fat-soluble vitamin that is obtained through sunlight exposure and dietary sources like fatty fish and fortified foods. It plays an important role in bone and immune health by aiding in calcium absorption and bone mineralization. Testing for vitamin D levels has increased in recent years due to research linking vitamin D deficiency to diseases like cancer, heart disease, diabetes and depression. While vitamin D shows promise for many health benefits, more research is still needed to fully understand its therapeutic potential.

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Vitamin D Spikes in testing and miracle cures PFC Eaker
What is Vitamin D? Fat Soluble Vitamin Found in food Absorbed through sunlight exposure Converted to hormone form through liver and kidney
Two Major Forms of Vitamin D Vitamin D2, ergocalciferol Vitamin D3, cholecalciferol
Other Forms of Vitamin D Vitamin D1: molecular compound of ergocalciferol with lumisterol, 1:1 Vitamin D4: 22-dihydroergocalciferol Vitamin D5: sitocalciferol (made from 7- dehydrosisterol)
Vitamin d presentation
Vitamin d presentation
Vitamin d presentation
Vitamin d presentation
What are the sources? Cod Liver Oil, 1 Tbs: 1,360 IU Salmon, cooked, 3 1/2 oz: 360 IU Mackerel, cooked, 3 1/2 oz: 345 IU Sardines, canned in oil, drained, 3 1/2 oz: 270 IU Milk, nonfat, reduced fat, and whole, vitamin D fortified, 1 c: 98 IU Margarine, fortified, 1 Tbs: 60 IU Pudding, 1/2 c prepared from mix and made with vitamin D fortified milk: 50 IU Dry cereal, Vitamin D fortified w/10% of the recommended daily value, 3/4 c: 40-50 IU (other cereals may be fortified with more or less vitamin D) Liver, beef, cooked, 3 1/2 oz: 30 IU Egg, 1 whole (vitamin D is present in the yolk): 25 IU
Exposure to sunlight Important source of vitamin D Season, latitude, time of day
What does Vitamin D do? Maintain normal blood levels of Calcium and Phosphorus Aids in absorption of calcium Promotes bone mineralization Prevents rickets in children and Osteomalacia in adults
Role in immunomodulation Binds to nuclear Vitamin D receptors (VDR) Immune enhancing and immunosuppressive effects Increase activity of NKCs Increased production of cathelicidin Therepeutic Clinical Applications
How much Vitamin D do we need? Ages 19-50: 200 International Units (IU) Ages 51-69: 400 IU Age 70 and older: 600 IU
Vitamin d presentation
When can vitamin D deficiency occur? Rickets Osteomalacia
Rickets/Osteomalacia
Who may need extra vitamin D to prevent a deficiency? Older Americans (greater than age 50) individuals with limited sun exposure occupations that prevent exposure to sunlight reduced ability to absorb dietary fat exclusively breast-fed infants
What is the health risk of too much vitamin D? nausea vomiting poor appetite constipation weakness weight loss
When is it ordered? 25 OH Vitamin D test 1,25 di OH Vitamin D test
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
What does the test result mean? 25 OH Vitamin D test Low blood levels = not getting enough exposure to sunlight problem with absorption from the intestines High levels = supplementation from vitamin pills or other nutritional supplements 1,25 di OH Vitamin D test Low levels = kidney disease one of the earliest changes to occur in persons with early kidney failure. High levels = excess parathryoid hormone diseases such as sarcoidosis or some lymphomas, that can make 1,25 di OH Vitamin D outside of the kidneys
Spike in Vitamin D testing ABC NEWS - NEW YORK, NY, USA Sunshine Vitamin May Cut Death Risk BBC NEWS - UNITED KINGDOM Pain Linked With Low Vitamin D BLOOMBERG.COM Death May Be Nearer For People Who lack Vitamin D BRITTANIA RADIO Vitamin D Can Heal Tuberculosis?
Current Research Cancers Heart Disease Stroke Diabetes Depression Muscle Weakness Birth Defects Obesity
Role in cancer prevention and recovery Calcitriol Induces death of cancer cells Regulates Cell growth, Differentiation etc. Daily intake of 1,000IU/day reduces risks
Vitamin D and Obesity Seasons Altitude Calcium Link between other diseases Treatable
Vitamin D and Diabetes Low serum levels at greater risk Lack of Vitamin D interferes with insulin secretion
Vitamin D and depression SAD 130 patients 600 or 4,000 IU supplements Re-evaluated 1 year later
Conclusion Vitamin D The wonder drug? LabCorp Testing volume doubled every ear for the past four years Quest Diagnostics Testing volume tripled between May 2006 and May 2008
Questions?

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Vitamin d presentation

  • 1. Vitamin D Spikes in testing and miracle cures PFC Eaker
  • 2. What is Vitamin D? Fat Soluble Vitamin Found in food Absorbed through sunlight exposure Converted to hormone form through liver and kidney
  • 3. Two Major Forms of Vitamin D Vitamin D2, ergocalciferol Vitamin D3, cholecalciferol
  • 4. Other Forms of Vitamin D Vitamin D1: molecular compound of ergocalciferol with lumisterol, 1:1 Vitamin D4: 22-dihydroergocalciferol Vitamin D5: sitocalciferol (made from 7- dehydrosisterol)
  • 9. What are the sources? Cod Liver Oil, 1 Tbs: 1,360 IU Salmon, cooked, 3 1/2 oz: 360 IU Mackerel, cooked, 3 1/2 oz: 345 IU Sardines, canned in oil, drained, 3 1/2 oz: 270 IU Milk, nonfat, reduced fat, and whole, vitamin D fortified, 1 c: 98 IU Margarine, fortified, 1 Tbs: 60 IU Pudding, 1/2 c prepared from mix and made with vitamin D fortified milk: 50 IU Dry cereal, Vitamin D fortified w/10% of the recommended daily value, 3/4 c: 40-50 IU (other cereals may be fortified with more or less vitamin D) Liver, beef, cooked, 3 1/2 oz: 30 IU Egg, 1 whole (vitamin D is present in the yolk): 25 IU
  • 10. Exposure to sunlight Important source of vitamin D Season, latitude, time of day
  • 11. What does Vitamin D do? Maintain normal blood levels of Calcium and Phosphorus Aids in absorption of calcium Promotes bone mineralization Prevents rickets in children and Osteomalacia in adults
  • 12. Role in immunomodulation Binds to nuclear Vitamin D receptors (VDR) Immune enhancing and immunosuppressive effects Increase activity of NKCs Increased production of cathelicidin Therepeutic Clinical Applications
  • 13. How much Vitamin D do we need? Ages 19-50: 200 International Units (IU) Ages 51-69: 400 IU Age 70 and older: 600 IU
  • 15. When can vitamin D deficiency occur? Rickets Osteomalacia
  • 17. Who may need extra vitamin D to prevent a deficiency? Older Americans (greater than age 50) individuals with limited sun exposure occupations that prevent exposure to sunlight reduced ability to absorb dietary fat exclusively breast-fed infants
  • 18. What is the health risk of too much vitamin D? nausea vomiting poor appetite constipation weakness weight loss
  • 19. When is it ordered? 25 OH Vitamin D test 1,25 di OH Vitamin D test
  • 35. What does the test result mean? 25 OH Vitamin D test Low blood levels = not getting enough exposure to sunlight problem with absorption from the intestines High levels = supplementation from vitamin pills or other nutritional supplements 1,25 di OH Vitamin D test Low levels = kidney disease one of the earliest changes to occur in persons with early kidney failure. High levels = excess parathryoid hormone diseases such as sarcoidosis or some lymphomas, that can make 1,25 di OH Vitamin D outside of the kidneys
  • 36. Spike in Vitamin D testing ABC NEWS - NEW YORK, NY, USA Sunshine Vitamin May Cut Death Risk BBC NEWS - UNITED KINGDOM Pain Linked With Low Vitamin D BLOOMBERG.COM Death May Be Nearer For People Who lack Vitamin D BRITTANIA RADIO Vitamin D Can Heal Tuberculosis?
  • 37. Current Research Cancers Heart Disease Stroke Diabetes Depression Muscle Weakness Birth Defects Obesity
  • 38. Role in cancer prevention and recovery Calcitriol Induces death of cancer cells Regulates Cell growth, Differentiation etc. Daily intake of 1,000IU/day reduces risks
  • 39. Vitamin D and Obesity Seasons Altitude Calcium Link between other diseases Treatable
  • 40. Vitamin D and Diabetes Low serum levels at greater risk Lack of Vitamin D interferes with insulin secretion
  • 41. Vitamin D and depression SAD 130 patients 600 or 4,000 IU supplements Re-evaluated 1 year later
  • 42. Conclusion Vitamin D The wonder drug? LabCorp Testing volume doubled every ear for the past four years Quest Diagnostics Testing volume tripled between May 2006 and May 2008

Editor's Notes

  • #43: Thanks to these studies and national headlines praising its apparent cancer-fighting properties it appears many people now consider vitamin d their wonder drug and are rushing to labs to have their levels tested. The patients requesting these tests through their physicains represent an increasingly health conscious-public. These patients want greater control over managing their own health, they have greater access to information related to health promotion and illness prevention, and there are a growing number of media stores that address their demand for news and information about personal health issues. Spikes are often seen when these three drivers come together as in the case of vitamin d There is no count on how many people get their vitamin d checked. But at testing giant LabCorp, the volume of vitamin D tests doctors order has, on average, doubled every year for the past four. So far this year, test orders are up another 90%. At competitor Quest Diagnostics, the volume of D tests approximately tripled between may 2006 and last may. http://www.virginiahopkinstestkits.com/vitamindtest.html http://abcnews.go.com/video/playerIndex?id=5563319 Vitamin D video