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Vmax and Innocor
Acomparisonoftwometaboliccartsduringrestandexercise
Zach Blain
Methods
 The volume of oxygen consumed and utilized by working muscle per
minute during rest or exercise.
 Defined by Fick:
 VO2 = Q  a-vO2 difference
 Q = SV  HR
 Q= Cardiac output; SV= Stroke volume; HR= Heart rate
 Calculated as:
 VO2 = [VE  (FEN2 / FIN2)  FIO2]  [VE  FEO2]
 VE= Ventilation, volume/min; FEN2= Fraction of expired nitrogen; FIN2= Fraction of inspired
nitrogen; FIO2= Fraction of inspired oxygen; FEO2= Fraction of expired oxygen
 To measure Q
 Pulmonary artery catheter (PAC)
 To measure a-vO2 Diff
 Arterial venous catheter
 blood sampling
How they work
Innocor
 Flowmeter
 Gas Analyzer
 Oxygen sensor
Vmax
 Flow/Volume
 O2 Analyzer
 CO2 Analyzer
 Flash Multi-Gas
Innocor Vmax
Purpose
The aim of this study is to compare the metabolic
measurements between Vmax and Innocor simultaneously
during rest and exercise.
Hypothesis
It is hypothesized that there will be no difference between Vmax
and Innocor during rest and exercise.
Design and Protocol
 Simultaneous measurements
 Baseline
 50 W
 100 W
 150 W
 200 W
 250 W
 300 W
 Staged steady state
exercise - 2 minutes
Demographics
Patient Demographics
Participants(male/female) 7 (4/3)
Age (years) 24 賊 3
Height (cm) 171 賊 8
Weight (kg) 73 賊 20
BMI (kg/m族) 25 賊 6
Absolute VO2/ VCO2 vs. Workloads
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
0 50 100 150 200 250 300
VO(L/min)
Workload (Watts)
Vmax
Innocor
*
* Significant Difference P< 0.05
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
0 50 100 150 200 250 300
VCO(L/min)
Workload (Watts)
Vmax
Innocor
*
Figure 2: Absolute VO2 (L/min) vs Workload (Watts) Figure 3: Absolute VCO2 (L/min) vs Workload (Watts)
Ventilation
0
0.5
1
1.5
2
2.5
3
3.5
4
0 50 100 150 200 250 300Vt(litersperbreath)
Workload (Watts)
Vmax
Innocor
0
10
20
30
40
50
0 50 100 150 200 250 300
RR(breathspermin)
Workload (Watts)
Vmax
Innocor
Figure 4: Respiration rate (breaths per min) vs.
Workload (Watts)
Figure 5: Tidal volume (liters per breath) vs.
Workload (Watts)
Discussion
 No significant change in results for low workloads
 After 200W there becomes a deviation in the results
 No significant difference in the respiration, at any
workload
 VO2 and VCO2 at high workloads (300W)
 Account for gas analysis
 FIO2 and FEO2
Features
Features
Safe Yes Yes
Start up cost 160,000 60,000
Mobility Minimal Maximal
Skill required Maximal Minimal
Range Rest- Maximal? Rest-Maximal?
Issues
Technician
Mouthpiece discomfort
Vmax Innocor
Conclusion
Both Vmax and Innocor can attain similar
results for lower workloads, but begin to drift
during higher workloads.
Acknowledgments
 Brad Byers
 Desi Fuhr
 Karishma Kapoor
 Linn Moore
 Melissa Bouwsema
 Michael Stickland
 Vince Tedjasaputra
References
 Allen et al. (2013). ACSMs Guidelines for exercise testing and prescription.
Baltimore, MD. Wolters Kluwer, Lippincott Williams &Wilkins
 Beekley et al. (2004). Cross-Validation of the YMCA Submaximal Cycle
Ergometer Test to Predict VO2max. Research Quarterly for Exercise
and Sport. 75:3, 337-342.
 CareFusion Corporation. (2014). Vmax Encore Metabolic Cart. Retrieved
from www.carefusion.com
 Innovision ApS. (2014). Innocor. Retrieved from www.innovision.dk
 Stringer, W. Hansen, J. Wasserman, K. (1997). Cardiac output estimated
noninvasively from oxygen uptake during exercise. J Appl Physiol
82:908-912.
 Welch, HG. Pedersen, PK. (1981). Measurement of metabolic rate in
hyperoxia. J Appll Physiol Respir Environ Exerc Physiol. Sep; 51(3):
725-31.
15
20
25
30
35
40
45
50
55
50 100 150 200 250 300
VO2(ml/kg/min)
Workload (Watts)
Vmax
Innocor
Predicted VO2
Figure 6: Relative VO2 (ml/kg/min) vs. Workloads (Watts)
VO2 = (Watts (Watts)/ Bodyweight (kg)  10.8) + 7ml/kg/min

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Vmax and Innocor presentation

  • 2. Methods The volume of oxygen consumed and utilized by working muscle per minute during rest or exercise. Defined by Fick: VO2 = Q a-vO2 difference Q = SV HR Q= Cardiac output; SV= Stroke volume; HR= Heart rate Calculated as: VO2 = [VE (FEN2 / FIN2) FIO2] [VE FEO2] VE= Ventilation, volume/min; FEN2= Fraction of expired nitrogen; FIN2= Fraction of inspired nitrogen; FIO2= Fraction of inspired oxygen; FEO2= Fraction of expired oxygen To measure Q Pulmonary artery catheter (PAC) To measure a-vO2 Diff Arterial venous catheter blood sampling
  • 3. How they work Innocor Flowmeter Gas Analyzer Oxygen sensor Vmax Flow/Volume O2 Analyzer CO2 Analyzer Flash Multi-Gas Innocor Vmax
  • 4. Purpose The aim of this study is to compare the metabolic measurements between Vmax and Innocor simultaneously during rest and exercise. Hypothesis It is hypothesized that there will be no difference between Vmax and Innocor during rest and exercise.
  • 5. Design and Protocol Simultaneous measurements Baseline 50 W 100 W 150 W 200 W 250 W 300 W Staged steady state exercise - 2 minutes
  • 6. Demographics Patient Demographics Participants(male/female) 7 (4/3) Age (years) 24 賊 3 Height (cm) 171 賊 8 Weight (kg) 73 賊 20 BMI (kg/m族) 25 賊 6
  • 7. Absolute VO2/ VCO2 vs. Workloads 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 0 50 100 150 200 250 300 VO(L/min) Workload (Watts) Vmax Innocor * * Significant Difference P< 0.05 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 0 50 100 150 200 250 300 VCO(L/min) Workload (Watts) Vmax Innocor * Figure 2: Absolute VO2 (L/min) vs Workload (Watts) Figure 3: Absolute VCO2 (L/min) vs Workload (Watts)
  • 8. Ventilation 0 0.5 1 1.5 2 2.5 3 3.5 4 0 50 100 150 200 250 300Vt(litersperbreath) Workload (Watts) Vmax Innocor 0 10 20 30 40 50 0 50 100 150 200 250 300 RR(breathspermin) Workload (Watts) Vmax Innocor Figure 4: Respiration rate (breaths per min) vs. Workload (Watts) Figure 5: Tidal volume (liters per breath) vs. Workload (Watts)
  • 9. Discussion No significant change in results for low workloads After 200W there becomes a deviation in the results No significant difference in the respiration, at any workload VO2 and VCO2 at high workloads (300W) Account for gas analysis FIO2 and FEO2
  • 10. Features Features Safe Yes Yes Start up cost 160,000 60,000 Mobility Minimal Maximal Skill required Maximal Minimal Range Rest- Maximal? Rest-Maximal? Issues Technician Mouthpiece discomfort Vmax Innocor
  • 11. Conclusion Both Vmax and Innocor can attain similar results for lower workloads, but begin to drift during higher workloads.
  • 12. Acknowledgments Brad Byers Desi Fuhr Karishma Kapoor Linn Moore Melissa Bouwsema Michael Stickland Vince Tedjasaputra
  • 13. References Allen et al. (2013). ACSMs Guidelines for exercise testing and prescription. Baltimore, MD. Wolters Kluwer, Lippincott Williams &Wilkins Beekley et al. (2004). Cross-Validation of the YMCA Submaximal Cycle Ergometer Test to Predict VO2max. Research Quarterly for Exercise and Sport. 75:3, 337-342. CareFusion Corporation. (2014). Vmax Encore Metabolic Cart. Retrieved from www.carefusion.com Innovision ApS. (2014). Innocor. Retrieved from www.innovision.dk Stringer, W. Hansen, J. Wasserman, K. (1997). Cardiac output estimated noninvasively from oxygen uptake during exercise. J Appl Physiol 82:908-912. Welch, HG. Pedersen, PK. (1981). Measurement of metabolic rate in hyperoxia. J Appll Physiol Respir Environ Exerc Physiol. Sep; 51(3): 725-31.
  • 14. 15 20 25 30 35 40 45 50 55 50 100 150 200 250 300 VO2(ml/kg/min) Workload (Watts) Vmax Innocor Predicted VO2 Figure 6: Relative VO2 (ml/kg/min) vs. Workloads (Watts) VO2 = (Watts (Watts)/ Bodyweight (kg) 10.8) + 7ml/kg/min

Editor's Notes

  • #3: The Gold Standard for VO2 Highly invasive
  • #4: Both Innocor and Vmax has many features for measuring. Such as: Cardiac output or spirometry. However, the main focus was on the breath by breath method Innocor GAS, Photo acoustic spectroscopy; Oxygen, Laser absorption spectroscopy; Flow, Differential pressure Vmax- Flow, Mass flow sensor; Oxygen, Electro chemical cell; CO2 & Flash multi-gas, non-disersice infrared, thermopile
  • #6: If the individuals was not at steady state, we would hold the stage for an additional minute T-test was used to compare innocor and vmax at each workload Steady State- VO2 (L/min) 0.150ml -VCO2 (L/min) 0.150ml -VO2 (ml/kg/min) 2-3 ml/kg/min
  • #15: An article from Beekley. He preformed a cross-validation of the YMCA to predict VO2. The mean difference between the CE VO2max and the YMCA test was 6.83 ml/kg/min. 10.8 = O2 cost of cycling against external load (resistance) 7 = O2 cost of cycling with zero load