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WBC

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kishorchandra7

This document summarizes the different types of white blood cells (WBCs), including their classification, structures, and functions. It discusses neutrophils, eosinophils, basophils, lymphocytes, and monocytes. Some key points include: - WBCs are classified into neutrophils, eosinophils, basophils, lymphocytes, and monocytes. - Neutrophils have multilobed nuclei and granules containing enzymes to kill bacteria during phagocytosis. They are the first responders of the immune system. - Eosinophils contain granules that help attack parasites and reduce allergic inflammation. - Basophils contain histamine and other substances that cause immediate hypersensitivity reactions

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WBC
WBC • Wbc or leukocyte are the nucleated formed elements of blood.
WBC are classified in to two grp
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NEUTROPHILS Nucleus- Multilobed Arneth Count Granules- Primary- Hydrolases Phosphatase (Azurophil) Myeloperoxidase Sulphatase Lysozyme Nuclease Cathepsin G Glycosidase Secondary- Lactoferrin Vit B12 Binding Various receptor proteins proteins Pools.of neutrophil- I. BM pool- 90% Circulating II. Intravascular pool- 3% III. Tissue pool- 7% Marginal Functions - 1.Defence - a) 1st line b) 2nd line 2. Febrile response
WBC
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EOSINOPHIL Granules- MBP(major basic protein) Eosinophil peroxidase Cationic protein ECF – A(eosinophilic chemotactic) factor Functions – • Attach and kill parasites too large to phagocytose (hydrolytic enzyme, highly reactive O2 species, MBP) • Reduce the ill effect of allergic inflammation (Histaminase, arylsulphatase) • Anaphylactic reaction (ECF-A) • Weak phagocytosis
WBC
BASOPHIL • Granules contain histamine, heparin, bradykinin, serotonin, slow reacting substances of anaphylasxis and no. of lysosomal enzymes. • FUNCTIONS- 1. Immediate hypersensitivity reaction ( Fall in BP, Bronchospasm) 2. Heparin- Anticoagulant, influence lipid metabolism LYMPHOCYTES 2 Types – Large - Precursor Small – Immunity (B & T Lymphocytes)
WBC
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MONOCYTE  First 2-3 days- Immature  Mature 24 hrs after neutrophil (Second Line Defence) Enter tissue Mobile Macrophage(60-80µm) Monocyte (Months & Yrs) Monocytes+ Mobile macrophage + Fixed tissue Macrophage + Few specialized Endothelial cells (BM, Spleen & LN) = R.E. SYSTEM Types-  Tissue Macrophage (Histiocytes)  Macrophage in Lymph Node  Macrophage in Lungs (Alveolar Macrophage)  Macrophage in Liver (Kupffer cells)  Macrophage of Spleen and BM.
WBC
WBC
Neutrophil Monocyte 3-20 bacteria > 100 bacteria Afterwards- Inactive and dies Afterwards- Digests, extrude the residual product and survive for many yrs 3 selective procedures – 1. Smooth surface 2. Protective protein coat 3. Opsonin productions Role of Defensins (Oxidizing agents)- O2 -, H2O2, OH- , HOCl- Phagocytosis anaerobic Bacterias resistant to digestive enzymes are killed by defensins

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WBC

  • 2. WBC • Wbc or leukocyte are the nucleated formed elements of blood.
  • 3. WBC are classified in to two grp
  • 16. NEUTROPHILS Nucleus- Multilobed Arneth Count Granules- Primary- Hydrolases Phosphatase (Azurophil) Myeloperoxidase Sulphatase Lysozyme Nuclease Cathepsin G Glycosidase Secondary- Lactoferrin Vit B12 Binding Various receptor proteins proteins Pools.of neutrophil- I. BM pool- 90% Circulating II. Intravascular pool- 3% III. Tissue pool- 7% Marginal Functions - 1.Defence - a) 1st line b) 2nd line 2. Febrile response
  • 19. EOSINOPHIL Granules- MBP(major basic protein) Eosinophil peroxidase Cationic protein ECF – A(eosinophilic chemotactic) factor Functions – • Attach and kill parasites too large to phagocytose (hydrolytic enzyme, highly reactive O2 species, MBP) • Reduce the ill effect of allergic inflammation (Histaminase, arylsulphatase) • Anaphylactic reaction (ECF-A) • Weak phagocytosis
  • 21. BASOPHIL • Granules contain histamine, heparin, bradykinin, serotonin, slow reacting substances of anaphylasxis and no. of lysosomal enzymes. • FUNCTIONS- 1. Immediate hypersensitivity reaction ( Fall in BP, Bronchospasm) 2. Heparin- Anticoagulant, influence lipid metabolism LYMPHOCYTES 2 Types – Large - Precursor Small – Immunity (B & T Lymphocytes)
  • 24. MONOCYTE  First 2-3 days- Immature  Mature 24 hrs after neutrophil (Second Line Defence) Enter tissue Mobile Macrophage(60-80µm) Monocyte (Months & Yrs) Monocytes+ Mobile macrophage + Fixed tissue Macrophage + Few specialized Endothelial cells (BM, Spleen & LN) = R.E. SYSTEM Types-  Tissue Macrophage (Histiocytes)  Macrophage in Lymph Node  Macrophage in Lungs (Alveolar Macrophage)  Macrophage in Liver (Kupffer cells)  Macrophage of Spleen and BM.
  • 27. Neutrophil Monocyte 3-20 bacteria > 100 bacteria Afterwards- Inactive and dies Afterwards- Digests, extrude the residual product and survive for many yrs 3 selective procedures – 1. Smooth surface 2. Protective protein coat 3. Opsonin productions Role of Defensins (Oxidizing agents)- O2 -, H2O2, OH- , HOCl- Phagocytosis anaerobic Bacterias resistant to digestive enzymes are killed by defensins