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What Is Neuropathic Pain?
Allan Gordon MD
Wasser Pain Management Centre
University of Toronto Centre for the Study
of Pain
 Definition of neuropathic pain
 Symptoms and signs
 Conditions producing neuropathic
pain
 Treatments
 Cost of NeP
Definition of Neuropathic Pain
 Pain resulting from or thought to be
resulting from a disturbance of the
central or peripheral nervous
system
 Acute vs Chronic (six months)
 Non Cancer vs Cancer
How common is it?
 UK 1% point prevalence
 But likely more common than that
Symptoms and Signs
 Spontaneous vs stimulus evoked
 Burning, constant, throbbing vs jabbing,
stabbing
 Mild, moderate, severe
 Distribution may not along classical
neuroanatomical lines
 Associated with
analgesia
hyperalgesia
allodynia
Fellow travelers
 Sleep
 Mood
 Recreation
 Anxiety
 Sex
 Work
 QOL and function
Conditions producing neuropathic pain
 Diabetic neuropathy
 Post herpetic neuralgia
 Cervical and lumbar radiculopathy
 Post thoracotomy, post mastectomy
 Multiple sclerosis
 Post-stroke
 Phantom limb
Most likely neuropathic pain
 Vulvar pain
 Interstitial cystitis
 Atypical facial neuralgia
 Fibromyalgia
Neuropathic pain a component
 Post-inguinal hernia
 Osteoarthritis of knee
 Post TMJ replacement
Management
 Pharmacotherapy
Oral: Tricyclic antidepressant
Antiepileptic
Opiate Methadone
Topical: Lidocaine
Capsacin
Intrathecal: Opiate Clonidine
Other therapies
 Rehabilitation therapy
 Behavioural therapy
 Psychotherapy
 CBT; Meditation; Hypnotherapy
 Alternative: Acupuncture
 Neurostimulation
 Neuroblock
 Injections including Botox
 Surgery
Cost of neuropathic pain
 Mild pain: $2619
 Moderate pain: $3972
 Severe pain: $8360
 Average $4614
 Average cost $4614/3 months
 Direct costs $1068
 Indirect costs $3546
Conclusions
 Neuropathic pain is being more
commonly recognized
 Pain can be mild to severe
 Characteristic symptoms
 Seen in many common conditions
 Multimodal treatment
 Expensive in human and economic
terms

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What is neuropathic pain

  • 1. What Is Neuropathic Pain? Allan Gordon MD Wasser Pain Management Centre University of Toronto Centre for the Study of Pain
  • 2. Definition of neuropathic pain Symptoms and signs Conditions producing neuropathic pain Treatments Cost of NeP
  • 3. Definition of Neuropathic Pain Pain resulting from or thought to be resulting from a disturbance of the central or peripheral nervous system Acute vs Chronic (six months) Non Cancer vs Cancer
  • 4. How common is it? UK 1% point prevalence But likely more common than that
  • 5. Symptoms and Signs Spontaneous vs stimulus evoked Burning, constant, throbbing vs jabbing, stabbing Mild, moderate, severe Distribution may not along classical neuroanatomical lines Associated with analgesia hyperalgesia allodynia
  • 6. Fellow travelers Sleep Mood Recreation Anxiety Sex Work QOL and function
  • 7. Conditions producing neuropathic pain Diabetic neuropathy Post herpetic neuralgia Cervical and lumbar radiculopathy Post thoracotomy, post mastectomy Multiple sclerosis Post-stroke Phantom limb
  • 8. Most likely neuropathic pain Vulvar pain Interstitial cystitis Atypical facial neuralgia Fibromyalgia
  • 9. Neuropathic pain a component Post-inguinal hernia Osteoarthritis of knee Post TMJ replacement
  • 10. Management Pharmacotherapy Oral: Tricyclic antidepressant Antiepileptic Opiate Methadone Topical: Lidocaine Capsacin Intrathecal: Opiate Clonidine
  • 11. Other therapies Rehabilitation therapy Behavioural therapy Psychotherapy CBT; Meditation; Hypnotherapy Alternative: Acupuncture Neurostimulation Neuroblock Injections including Botox Surgery
  • 12. Cost of neuropathic pain Mild pain: $2619 Moderate pain: $3972 Severe pain: $8360 Average $4614
  • 13. Average cost $4614/3 months Direct costs $1068 Indirect costs $3546
  • 14. Conclusions Neuropathic pain is being more commonly recognized Pain can be mild to severe Characteristic symptoms Seen in many common conditions Multimodal treatment Expensive in human and economic terms