White Blood Cells
Download as pptx, pdf1 like110 views
This document discusses white blood cells (WBCs), including their normal counts in healthy individuals and morphologic characteristics. It describes the two main types of blast cells - myeloblasts and lymphoblasts - and their features. The normal ranges of total WBC count and differential leukocyte count are provided for various age groups. Details are given on the morphology, normal function, and pathologic variations of the different types of WBCs: polymorphonuclear leukocytes, lymphocytes, monocytes, eosinophils, and basophils. Common causes of increased or decreased counts are listed for each type.
White Blood Cells
- 5. . . . . .
- 6. Morphologic Characteristics of the Blast cells in Romanowsky stains. Features Myeloblast Lymphoblast Size 10-18 亮m 10-18 亮m Nucleus Round or oval Round or oval Nuclear Chromatin Fine meshwork Slightly clumped Nuclear Membrane Very fine Fairly dense Nucleoli 2-5 1-2 Cytoplasma Scanty, blue,Agranular,Auer rods my be seen Scanty, clear blue, Agranular . . . . . . . . . . .....
- 7. Normal White Blood cells Count in Healthy. TLC Absolute Count Adult 4000-11000/亮l Infant (Full term, at birth) 10,000-25,000/亮l Infants(1 yrs) 6,000-16,000/亮l Children (4-7 yrs) 5,000-15,000/亮l Children (8-12 yrs) 4,500-13,5000/亮l DLC ( In Adults) Absolute Count Polymorphs (40-75%) 2,000-7,500/亮l Lymphocytes ( 20-50%) 1,500-4,000/亮l Monocytes (2-10%) 200-800/ 亮l Eosinophils (1-6%) 40-400/亮l Basophils (<1%) 10-200/亮l . . . . . . . . . . . . . . . . . . . .
- 8. Polymorphs Morphology Normal Function Chemotaxis Phagocytosis Killing Lobes Cytoplasm Granules 12-15亮m
- 10. Pathologic Variations Variation in count Neutrophilia:- Acute infection Inflammation Intoxication, Acute haemorrhage Myeloproliferative disorders Neutropenia:- Certain infection Overwhelming bacterial infection Drugs, Chemical and Physical agents Certain haematological and other disease, Anaphylactic shock Rare hereditary Congenital or Familial disorders.
- 11. Variation in Morphology Granules Vacuoles D哥hle bodies Nuclear Abnormalities Sex Chromatin A shift to left A shift to right Pelger-Hut anamoly Defective Function:- Chemoatxic, Phagocytosis, and Killing.
- 12. Lymphocytes Morphology T lymphocytes B lymphocytes NK cells Pathologic Variations Lymphocytosis Lymphopenia
- 13. Monocytes Morphology Functions Phagocytosis Immunologic function As mediator of inflammation Pathologic Variations Certain Bacterial infection viral infection Protozoal and rickettsial infection Haematopoietic disorder Malignancies Granulomatous ds. Collagen vascular ds.
- 14. Eosinophils Morphology Pathology Variations Eosinophilia Allergic Disorder Parasites infestations Skin diseases L哥effers syndrome PIE syndrome Trophical Eosinophilia Hematopoietic disorder Malignancies Eosinopenia Adrenal steroid and ACTH induce
- 15. Basophils Morphology Pathologic Variations Chronic myeloid leukaemia Polycythaemia Vera Myeloscrlerosis Myxoedema Ulcerative colitis Following Splenectomy Hodgkins ds. Urticaria pigmentosa