Zika Virus and the Eye
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Zika virus infection in infants can cause ocular abnormalities. This case series examined the eyes of 29 Brazilian infants with microcephaly presumed to be caused by congenital Zika virus infection. Ocular examinations found abnormalities in 17 eyes of 10 infants, most commonly chorioretinal lesions near the macula or optic disc. Examples of lesions included pigmentary mottling, atrophic scars, and enlarged cup-to-disc ratios. The retinal findings were similar to those seen in other congenital viral infections like West Nile virus. Further research is needed to confirm Zika virus as the cause using serological testing, and ophthalmologists should be aware of the potential for ocular involvement in congenital
Zika Virus and the Eye
- 1. Zika Virus Infection & the Eye
- 2. Zika Virus Infection & the Eye
- 3. Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection Salvador, Brazil Bruno de Paula Freitas, MD; Jo達o Rafael de Oliveira Dias, MD; Juliana Prazeres, MD; Gielson Almeida Sacramento, BS; Albert Icksang Ko, MD; Maur鱈cio Maia, MD, PhD; Rubens Belfort Jr, MD, PhD Department of Ophthalmology, Hospital Geral Roberto Santos, Salvador, Brazil Vision Institute, Department of Ophthalmology, Paulista Medical School, Federal University of S達o Paulo, S達o Paulo, Brazil Gon巽alo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Brazil Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut JAMA Ophthalmol. Published online February 09, 2016
- 8. Design Case Series at Tertiary Hospital 29 infants with microcephaly and presumed congenital Zika 2015: 1st Dec - 25 th Dec Interventions Wide field digital imaging DDx of infections ruled out through serological and clinical examinations Design and Interventions
- 9. 23/29 mothers suspected Zika during pregnancy. Trimester: 18 = 1st; 4 = 2nd; 1 = 3rd. 58 eyes of 29 children 17 eyes of 10 children = Ocular Abnormalities 7/10 = Bilateral Results
- 10. Examples
- 11. 2 month old infant RE: granular, pigmentary mottling in the macular. LE: Chorioretinal lobulated atrophic lesion and slight pigmentary mottling
- 12. 1 month old infant RE & LE: paramacular supertemporal round chorioretinal atrophy surrounded by a hyper pigmented halo and hyper pigmented mottling
- 13. I month old infant RE: enlarged cup-disc ratio and macular pigmentary mottling LE: roundish macular chorioretinal atrophic lesion with a hyper pigmented halo and pigmentary mottling, as well as an enlarged cup-disc ration
- 14. 1 month old infant RE & LE: supertemporal perimacular chorioretinal scar with perilesional pigmentary mottling
- 15. 20 day old infant RE: optic disc hypoplasia, peripapillary nasal atrophy and excavated nasal round lesion with a hyper hyper pigmented halo, with a colobomatous-like aspect LE: optic disc hypoplasia, peripapillary nasal atrophy, and a retinal nasal lesion with a similar pattern
- 16. Findings in infants with microcephaly & presumed Zika Virus congenital infection
- 17. Discussion Major health problem Retinal lesions Posterior pole Optic disc Screen infected mothers without microcephalic infants?
- 18. Limitations 1 hospital General findings Lack of prior research Presumed Zika
- 19. Conclusions Retinal lesions similar to West Nile virus Need serological tests to confirm findings Micro = routine exam Ophthalmologists should be aware