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controlled release ir diffusion controlled classical optimization ire atr crystal partition coefficient factorial design transdermal drug delivery sustained release activation controlled rate controlled ftir applications of crdds micro reservoir dissolution controlled optimization contour plot full factorial design gc bms matrix hydrophilic norplant norgestomet implant contract research cro fda who mhra tga anvisa cdsco regulatory process automation qbd drug design full factorial search engine optimization optimization classification pharmaceutical industry effluent testing factory hazards fire hazards hazards waste water treatment mottling tablets uncoated defects chiping capping coated bonding immobilization adsorption silylation acylation derivatization gas chromatography alkylation evanescent wave micro atr spectroscopy reflectance attenuated infrared hydrogel thermosensitive paclitaxel industry chemical hazards electron impact ionization osmotically controlled hydrodynamically controlled systems hydrodynamically controlled systemsosmotically con polymeric types matrix type chemical shifts nmr sonophoresis magnetophoresis iontophoresis dermis epidermis skin skin layers factors affection mucoadhesion polymers cones delivery antibiotic delievry vaginald rug delivery solution diffusivity polymer diffusivity solution solubility polymer solubility nanotoxicology esi mass spectroscopy efi maldi field ionization chemical ionization solid dispersion complexation solvent evaporation hptlc xrd excipient level of testing tlc compatibility testing dispersive ir penicillin insulin hormones corticosteroides injection injectables feedback controlled applications of controlled release types diffusion activation controlled drug delivery dissolution targeted drug delivery erosion rate controlled drug delivery permeability solubility salt forms absorption ph hypothesis tablet compression consolidation enzyme