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pharmaceutical pharmacy surface tension science physical pharmacy physics application b pharm measurement interfacial tension 肠补迟颈贸苍 electricity zeta potential nernst potential electrical double layer stability spreading coefficient wilhelmy plate liquids bpharm ointments creams du nuoy ring method maximum bubble pressure capillary rise method cosmetics routes mechanisms biology bioavailability drugaction active transport passive diffusion biopharmaceutics drug absorption hlb value hlb scale surfactants cmc micelle pharma hlb critical micellar concentration suspension adsorption chemistry ions anion formulation potential spreading