狠狠撸show is from the University of Michigan Medical
School's M2 Psychiatry sequence
View additional course materials on Open.Michigan: openmi.ch/med-M2Psych
Interpreting population pharmacokinetic pharmacodynamic analyses – a clinical...Ming Chia Lee
?
Population pharmacokinetic-pharmacodynamic analyses allow modeling of drug response data from multiple individuals to quantify variability between patients and identify factors influencing this variability. A typical population model includes three elements: 1) a structural model describing the average response over time, 2) a model of heterogeneity characterizing variability between individuals, and 3) a model of uncertainty accounting for residual differences from the model. Such analyses are useful for optimizing drug dosing, designing clinical trials, and identifying covariates like age, weight or organ function that influence a drug's effects. The significance of identified covariate relationships must consider biological plausibility, clinical importance, and statistical measures.
Inhaled Corticosteroids Increase the Risk of Pneumonia in Patients with Chron...Ming Chia Lee
?
- The study examined the risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD) using inhaled corticosteroids (ICS) using a national health insurance database in Taiwan.
- It found that ICS use was independently associated with an increased risk of pneumonia in a dose-dependent manner, even after controlling for COPD severity.
- The incidence of pneumonia was higher during periods of ICS use and decreased after discontinuing ICS, while the incidence of acute exacerbations continued to decrease.
- The results provide evidence that ICS should be judiciously prescribed in COPD patients due to the risk of increasing pneumonia.
Impact of DM and its control on the risk of developing TB in TaiwanMing Chia Lee
?
This study investigated the impact of diabetes mellitus (DM) and its control on the risk of developing active tuberculosis (TB) using Taiwan's National Health Insurance Research Database. The results showed that: (1) DM significantly increased the risk of TB and this effect persisted for at least 5 years, (2) the risk of TB was higher with worse DM control as measured by hospital admissions and medication doses, (3) better adherence to anti-DM medication was protective against TB. The study suggests that controlling DM may help prevent some cases of TB.
Interpreting population pharmacokinetic pharmacodynamic analyses – a clinical...Ming Chia Lee
?
Population pharmacokinetic-pharmacodynamic analyses allow modeling of drug response data from multiple individuals to quantify variability between patients and identify factors influencing this variability. A typical population model includes three elements: 1) a structural model describing the average response over time, 2) a model of heterogeneity characterizing variability between individuals, and 3) a model of uncertainty accounting for residual differences from the model. Such analyses are useful for optimizing drug dosing, designing clinical trials, and identifying covariates like age, weight or organ function that influence a drug's effects. The significance of identified covariate relationships must consider biological plausibility, clinical importance, and statistical measures.
Inhaled Corticosteroids Increase the Risk of Pneumonia in Patients with Chron...Ming Chia Lee
?
- The study examined the risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD) using inhaled corticosteroids (ICS) using a national health insurance database in Taiwan.
- It found that ICS use was independently associated with an increased risk of pneumonia in a dose-dependent manner, even after controlling for COPD severity.
- The incidence of pneumonia was higher during periods of ICS use and decreased after discontinuing ICS, while the incidence of acute exacerbations continued to decrease.
- The results provide evidence that ICS should be judiciously prescribed in COPD patients due to the risk of increasing pneumonia.
Impact of DM and its control on the risk of developing TB in TaiwanMing Chia Lee
?
This study investigated the impact of diabetes mellitus (DM) and its control on the risk of developing active tuberculosis (TB) using Taiwan's National Health Insurance Research Database. The results showed that: (1) DM significantly increased the risk of TB and this effect persisted for at least 5 years, (2) the risk of TB was higher with worse DM control as measured by hospital admissions and medication doses, (3) better adherence to anti-DM medication was protective against TB. The study suggests that controlling DM may help prevent some cases of TB.