1. Radiation causes acute inflammation in tissues through the release of inflammatory mediators from macrophages and other immune cells.
2. This causes the classic signs of inflammation like redness, swelling, heat and pain through increased blood flow and permeability.
3. Further downstream effects of inflammation include the recruitment of leukocytes to the injured tissue through cellular adhesion molecules and chemokines to fight infection and promote healing.
Irradiated mammals after nuclear accidents and experimental animals that received large doses of radiation show evidence of differences in brain serotonin levels, blood serotonin levels, tissue serotonin levels compared with radiation na誰ve mammals. Both short- and long-term radiation exposures affects the serotonin receptors that convert the chemical signal produced
by serotonin into functional changes in the signal-receiving cell.
To review the role of Radiation Neurotoxins in triggering, developing of radiation induced central nervous system injury.
Radiation Neurotoxins rapidly acting blood toxic lethal agent, which activated after irradiation and concentrated, circulated in interstitial fluid, lymph, blood with interactions with cell membranes, receptors and cell compartments.
The Role of Histamine in Radiation Toxic Effects .Dmitri Popov
油
Histamine油is an organic油nitrogenous油compound involved in local油immune responses油as well as regulating physiological function in the gut and acting as a油neurotransmitter. Histamine is involved in the油inflammatory response.
Toxicology of acute cerebrovascular radiation syndrome. part 3.Dmitri Popov
油
Dmitri Popov is a radiobiologist who studies acute cerebrovascular radiation syndrome. He discusses that the primary reaction after radiation exposure over 4.6 Gy typically occurs within hours. Doses between 0.25-1 Gy can cause transient functional impacts without permanent reduced capacity. Symptoms include hyperhydrosis, acrocyanosis, headaches, dizziness and sleep issues. Radiation exposure can lead to direct nervous system damage or secondary functional responses depending on the dose. Acute radiation effects include nausea and weakness and radiation toxic encephalopathy can occur in communicating, hypertensive, or epileptic/psychotic forms with intraparenchymal hemorrhaging as a complication.
This document describes acute gastrointestinal radiation syndrome (GI-ARS) and provides a grading system from mild to extremely severe. It notes symptoms include nausea, vomiting, diarrhea and anorexia. For severe cases it can cause infection, dehydration and electrolyte imbalance leading to death within 2 weeks. The severity of colon damage correlates with clinical manifestations. Survival rates depend on the grade of GI-ARS, with death occurring from 24 hours for extremely severe cases to 10-15 days for mild cases.
Transplantant Rejection: Experimental therapy with Protein A.Dmitri Popov
油
1) Organ transplantation involves moving an organ from one body to another to replace a damaged or absent organ in the recipient. Rejection can occur as the recipient's immune system attacks the foreign transplanted tissue.
2) Acute rejection occurs early after transplantation as cellular immunity develops, while chronic rejection explains long-term issues like fibrosis and loss of organ function.
3) Rejection involves both cellular immunity mediated by killer T cells and humoral immunity mediated by antibodies produced by B cells in response to donor antigens and major histocompatibility complex molecules.
Plague : Medical Management and original method of treatment.Dmitri Popov
油
A new effective method of coutermeasure against biological weapons, antiviral treatment of acute and chronic viral hepatitis B and C and against other viral diseases was used in medical practice in hospitals.Research results show this method as effective method against severe viral infections, warfare, and outbreak infections, Biological warfare, methicillin-resistant staphylococcus aureus.
Este documento contiene 10 preguntas sobre los sensores y funciones del robot Lego Nxt. Las preguntas cubren los diferentes sensores como el sensor ac炭stico, fotosensible y ultras坦nico, as鱈 como las funciones de las l叩mparas, el bluetooth y el servomotor. Tambi辿n incluye preguntas sobre conceptos como el registro de datos y la descarga y programaci坦n del robot a trav辿s de software.
Sarah Jane Black is seeking new employment opportunities and provides a detailed profile of her skills and experience. She has over 15 years of experience in customer service roles, most recently as a Duty Manager at The Southern Co-operative. Her profile highlights excellent communication and problem-solving skills developed through interactions with customers. Her work history also includes roles in administration, retail, and IT support. She is motivated to take on new challenges and develop additional skills.
Protection of humans during long space flight. using cannabis to reduce biol...Dmitri Popov
油
Protection of humans during long space flight. using cannabis to reduce biological consequences of high doses of radiation, treat stress, anxiety, and depression Associated with Long-term Space Flight to Mars.
The document discusses an anti-radiation antidote developed using antibodies against the membrane attack complex (MAC). MAC is activated after irradiation and plays a toxic role in acute radiation syndromes. Rabbits were inoculated with "specific radiation determinants" from irradiated animals to produce hyper-immune serum with high levels of IgG antibodies against MAC. Animals treated with these antibodies before and after lethal irradiation showed 60-75% survival rates and reduced radiation sickness symptoms compared to untreated controls where all animals died. The results suggest targeting MAC with specific antibodies may provide significant but incomplete protection against high radiation doses.
1. Radiation causes acute inflammation in tissues through the release of inflammatory mediators from macrophages and other immune cells.
2. This causes the classic signs of inflammation like redness, swelling, heat and pain through increased blood flow and permeability.
3. Further downstream effects of inflammation include the recruitment of leukocytes to the injured tissue through cellular adhesion molecules and chemokines to fight infection and promote healing.
Irradiated mammals after nuclear accidents and experimental animals that received large doses of radiation show evidence of differences in brain serotonin levels, blood serotonin levels, tissue serotonin levels compared with radiation na誰ve mammals. Both short- and long-term radiation exposures affects the serotonin receptors that convert the chemical signal produced
by serotonin into functional changes in the signal-receiving cell.
To review the role of Radiation Neurotoxins in triggering, developing of radiation induced central nervous system injury.
Radiation Neurotoxins rapidly acting blood toxic lethal agent, which activated after irradiation and concentrated, circulated in interstitial fluid, lymph, blood with interactions with cell membranes, receptors and cell compartments.
The Role of Histamine in Radiation Toxic Effects .Dmitri Popov
油
Histamine油is an organic油nitrogenous油compound involved in local油immune responses油as well as regulating physiological function in the gut and acting as a油neurotransmitter. Histamine is involved in the油inflammatory response.
Toxicology of acute cerebrovascular radiation syndrome. part 3.Dmitri Popov
油
Dmitri Popov is a radiobiologist who studies acute cerebrovascular radiation syndrome. He discusses that the primary reaction after radiation exposure over 4.6 Gy typically occurs within hours. Doses between 0.25-1 Gy can cause transient functional impacts without permanent reduced capacity. Symptoms include hyperhydrosis, acrocyanosis, headaches, dizziness and sleep issues. Radiation exposure can lead to direct nervous system damage or secondary functional responses depending on the dose. Acute radiation effects include nausea and weakness and radiation toxic encephalopathy can occur in communicating, hypertensive, or epileptic/psychotic forms with intraparenchymal hemorrhaging as a complication.
This document describes acute gastrointestinal radiation syndrome (GI-ARS) and provides a grading system from mild to extremely severe. It notes symptoms include nausea, vomiting, diarrhea and anorexia. For severe cases it can cause infection, dehydration and electrolyte imbalance leading to death within 2 weeks. The severity of colon damage correlates with clinical manifestations. Survival rates depend on the grade of GI-ARS, with death occurring from 24 hours for extremely severe cases to 10-15 days for mild cases.
Transplantant Rejection: Experimental therapy with Protein A.Dmitri Popov
油
1) Organ transplantation involves moving an organ from one body to another to replace a damaged or absent organ in the recipient. Rejection can occur as the recipient's immune system attacks the foreign transplanted tissue.
2) Acute rejection occurs early after transplantation as cellular immunity develops, while chronic rejection explains long-term issues like fibrosis and loss of organ function.
3) Rejection involves both cellular immunity mediated by killer T cells and humoral immunity mediated by antibodies produced by B cells in response to donor antigens and major histocompatibility complex molecules.
Plague : Medical Management and original method of treatment.Dmitri Popov
油
A new effective method of coutermeasure against biological weapons, antiviral treatment of acute and chronic viral hepatitis B and C and against other viral diseases was used in medical practice in hospitals.Research results show this method as effective method against severe viral infections, warfare, and outbreak infections, Biological warfare, methicillin-resistant staphylococcus aureus.
Este documento contiene 10 preguntas sobre los sensores y funciones del robot Lego Nxt. Las preguntas cubren los diferentes sensores como el sensor ac炭stico, fotosensible y ultras坦nico, as鱈 como las funciones de las l叩mparas, el bluetooth y el servomotor. Tambi辿n incluye preguntas sobre conceptos como el registro de datos y la descarga y programaci坦n del robot a trav辿s de software.
Sarah Jane Black is seeking new employment opportunities and provides a detailed profile of her skills and experience. She has over 15 years of experience in customer service roles, most recently as a Duty Manager at The Southern Co-operative. Her profile highlights excellent communication and problem-solving skills developed through interactions with customers. Her work history also includes roles in administration, retail, and IT support. She is motivated to take on new challenges and develop additional skills.
Protection of humans during long space flight. using cannabis to reduce biol...Dmitri Popov
油
Protection of humans during long space flight. using cannabis to reduce biological consequences of high doses of radiation, treat stress, anxiety, and depression Associated with Long-term Space Flight to Mars.
The document discusses an anti-radiation antidote developed using antibodies against the membrane attack complex (MAC). MAC is activated after irradiation and plays a toxic role in acute radiation syndromes. Rabbits were inoculated with "specific radiation determinants" from irradiated animals to produce hyper-immune serum with high levels of IgG antibodies against MAC. Animals treated with these antibodies before and after lethal irradiation showed 60-75% survival rates and reduced radiation sickness symptoms compared to untreated controls where all animals died. The results suggest targeting MAC with specific antibodies may provide significant but incomplete protection against high radiation doses.
Marihuana acute intoxication: express diagnosis with ELISADmitri Popov
油
This document discusses using an ELISA test to detect acute marijuana intoxication. It describes how ELISA tests work to detect THC metabolites in urine or saliva, which can confirm a diagnosis of acute marijuana intoxication. ELISA tests have detection limits of 20-100 ng/mL in urine and can detect THC and its metabolites for several hours after marijuana use. The document also provides background information on the pharmacokinetics of THC and discusses symptoms of acute marijuana intoxication.
Polyclonal/ monoclonal antibodies to serotonin receptors as a therapeutic age...Dmitri Popov
油
Polyclonal/monoclonal antibodies to serotonin receptors have potential as therapeutic agents. Serotonin receptors mediate effects of serotonin and are targets of many drugs. Antibodies to specific serotonin receptors could modulate receptor signaling and impact conditions like depression, anxiety, nausea, and pain. Developing therapeutic antibodies requires overcoming challenges but may help treat diseases influenced by the serotonin system.
Polyclonal, monoclonal antibodies to serotonin receptors as a therapeutic age...Dmitri Popov
油
Polyclonal/monoclonal antibodies to serotonin receptors have potential as therapeutic agents. Serotonin receptors mediate effects of serotonin and are targets of many drugs. Antibodies to specific serotonin receptors could modulate receptor signaling and impact conditions like depression, anxiety, nausea, and pain. Developing therapeutic antibodies requires overcoming challenges but may help treat diseases influenced by the serotonin system.
Comprehensive toxicology: Ionized Radiation as Carcinogen.Dmitri Popov
油
This document provides the full text of a chapter from the book "Comprehensive Toxicology" on ionizing radiation as a carcinogen. The chapter is copyrighted material provided for non-commercial educational use. It discusses the mechanisms of radiation damage at cellular and molecular levels, evidence of radiation-induced cancer from human populations and animal/in vitro studies, and models for assessing radiation cancer risk.
Polyclonal/Monoclonal antibodies to histamine receptors as a selective hista...Dmitri Popov
油
Polyclonal/monoclonal antibodies to histamine receptors have potential as selective antihistamine agents. They may block the inflammatory and immune effects of histamine by targeting its four receptor types: H1, H2, H3, and H4. Developing monoclonal antibodies as antagonists/agonists of these receptors could provide effective therapies for conditions like allergies, asthma, gastrointestinal issues, and cognitive disorders. Several companies produce antibodies to the different histamine receptors for research applications.
ANTIOXIDANTS AND POTASSIUM FERROCYANIDE, APROPHYLACTIC AND THERAPEUTIC MIXTU...Dmitri Popov
油
ANTIOXIDANTS AND POTASSIUM FERROCYANIDE, APROPHYLACTIC AND THERAPEUTIC MIXTURE COMPRISING THIS COMPOUND AND THE USE THEREOF FOR DECORPORATION OF RADIOCESIUM IN SUBJECTS AFFECTED BY NUCLEAR RADIATION
This document discusses research on developing an anti-radiation T cell vaccine. It describes T cells and their role in cell-mediated immunity, including recognizing radiation antigens created by radiation damage. The proposed anti-radiation T cell vaccine would generate immunological memory to radiation antigens, protecting against future radiation exposure through memory T cells that can quickly respond. It would work by modulating cytotoxic T cells to induce apoptosis in cells displaying radiation epitopes, without causing necrosis.
Implications for Immunotherapy of Acute Radiation Syndromes. Part 2.Dmitri Popov
油
Research Proposal:油Implications for Immunotherapy of Acute Radiation Syndromes. Part 2.
Dmitri Popov
Full-text available 揃 Research Proposal 揃 Feb 2017
File name:油Implications for Immunotherapy of ARS. Part 2.