ҽʦI94-ҽѧרʳ¿͢-dz̸ҩԸ
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The document discusses two types of liver damage: A) intrinsic toxicity caused by hepatotoxins like CCl4 and parquat which directly or indirectly cause hepatocyte necrosis, steatosis and cholestasis in a predictable, dose-dependent and experimentally reproducible manner. B) Host idiosyncrasies including immunologic reactions to drugs like phenytoin and halothane or rare metabolic reactions to isoniazid and methyldopa that unpredictably cause liver injury in susceptible individuals. The document also lists treatments for acetaminophen overdose including acetylcysteine.
ҽʦI94-ҽѧרʳ¿͢-dz̸ҩԸ
- 1. B C 10% 5% AԶ(intrinsic toxicity) ĸ (1) (predictable) (2) (dose dependent) (3) (high incidence) (4) (experimental reproducibility) (5) (rapid onset) (direct) (indirect) (hepatocyte) (duct epithelium) (hepatocyte necrosis) (steatosis) (cholestasis) CCl4 paraquat acetaminophen,steroi d,methotrexate Bخw|(host idiosyncratics) ĸ (1) (2) (3) (4)
- 2. (5) (immunologic idiosyncrasy) (cellular) (humoral) (eosinophilia) phenytoin, halothane (metabolic idiosyncrasy) isoniazid methyldopa sulfa drug insoniazid 1. 2. B C 3. 4. 5. acetaminophen acetylcysteine