Myasthenia gravis is caused by a problem with the transmission of nerve signals to muscles. The immune system produces antibodies that block or damage acetylcholine receptors in the muscle membrane, preventing muscles from contracting normally in response to nerve signals. This disrupts the connection between nerves and muscles, causing muscles to become weak and easily fatigued.
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Causes of myasthenia gravis
1. Causes of myasthenia gravis
# It is caused by a problem with the
transmission of nerve signals to the muscles.
# ACH comes into contact with specific receptors
on the muscle membrane, the receptors are
activated and cause the muscles to contract
(tighten).
# The immune system produces antibodies
(proteins) that block or damage the muscle ACH
receptors, which prevents the muscles contracting.
# The disruption between your nerves and muscles
means your muscles become weak and easily
tired.
# Immune systems produce antibodies that act
against the muscle receptors.
# Circulating antibodies cause weakness by
blocking acetylcholine receptors at the post-
synaptic neuromuscular junction, inhibiting the
stimulative effect of the neurotransmitter
acetylcholine.