FuddyMeers tells the story of Claire, a woman with amnesia who is trying to piece together her life with the help of supporting characters. She is led to her mother Gertie's house by the Limping Man for safety, but discovers he is actually her ex-husband impersonating her brother. Things escalate when the Limping Man is stabbed by Gertie. Claire learns she is the cause of the Limping Man's injuries and disabilities. In the end, Claire returns home with her husband Richard and son Kenny, having updated her memory book on the crazy events of her day.