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Gallstone Disease: Cholelithiasis
Overview, Diagnosis, and Treatment
Introduction
 - Cholelithiasis refers to the presence of
gallstones in the gallbladder.
 - Epidemiology: More common in females,
people over 40 years old, and individuals with
obesity or metabolic syndrome.
 - Types of Gallstones:
  Cholesterol stones (most common).
  Pigment stones (black or brown).
Clinical Signs and Symptoms
 - Asymptomatic: Many patients remain
asymptomatic.
 - Symptomatic (Biliary Colic):
  Pain: Right upper quadrant or epigastric
pain, radiates to the back or right shoulder,
often occurs after fatty meals.
  Nausea and Vomiting.
  Jaundice (if bile duct obstruction occurs).
  Fever and Chills (in cases of infection, e.g.,
cholecystitis).
Diagnostic Methods
 Laboratory Tests:
 - Liver function tests (LFTs): Elevated bilirubin,
ALT, AST, and ALP.
 - Complete blood count (CBC): Increased WBC
count in infection.
 - Pancreatic enzymes (amylase, lipase): To rule
out pancreatitis.
 Instrumental Diagnosis:
Treatment Overview
 Conservative Treatment:
 - Medications: Ursodeoxycholic acid (UDCA) to
dissolve cholesterol stones (limited efficacy).
 - Dietary Changes: Low-fat diet to reduce
symptoms.
 - Observation: For asymptomatic patients.
 Surgical Treatment:
 - Cholecystectomy:
Complications of Untreated
Gallstones
 - Acute cholecystitis.
 - Choledocholithiasis (stones in bile ducts).
 - Pancreatitis.
 - Gallbladder cancer (rare but serious).
Conclusion
 - Gallstone disease is common but treatable.
 - Early diagnosis and appropriate management
are key.
 - Surgical removal is the definitive treatment
for symptomatic cases.
References
 - Medical textbooks and clinical guidelines.
 - Reliable journals and articles on gallstone
disease.
 - Imaging and diagnostic studies on
cholelithiasis.

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  • 2. Introduction - Cholelithiasis refers to the presence of gallstones in the gallbladder. - Epidemiology: More common in females, people over 40 years old, and individuals with obesity or metabolic syndrome. - Types of Gallstones: Cholesterol stones (most common). Pigment stones (black or brown).
  • 3. Clinical Signs and Symptoms - Asymptomatic: Many patients remain asymptomatic. - Symptomatic (Biliary Colic): Pain: Right upper quadrant or epigastric pain, radiates to the back or right shoulder, often occurs after fatty meals. Nausea and Vomiting. Jaundice (if bile duct obstruction occurs). Fever and Chills (in cases of infection, e.g., cholecystitis).
  • 4. Diagnostic Methods Laboratory Tests: - Liver function tests (LFTs): Elevated bilirubin, ALT, AST, and ALP. - Complete blood count (CBC): Increased WBC count in infection. - Pancreatic enzymes (amylase, lipase): To rule out pancreatitis. Instrumental Diagnosis:
  • 5. Treatment Overview Conservative Treatment: - Medications: Ursodeoxycholic acid (UDCA) to dissolve cholesterol stones (limited efficacy). - Dietary Changes: Low-fat diet to reduce symptoms. - Observation: For asymptomatic patients. Surgical Treatment: - Cholecystectomy:
  • 6. Complications of Untreated Gallstones - Acute cholecystitis. - Choledocholithiasis (stones in bile ducts). - Pancreatitis. - Gallbladder cancer (rare but serious).
  • 7. Conclusion - Gallstone disease is common but treatable. - Early diagnosis and appropriate management are key. - Surgical removal is the definitive treatment for symptomatic cases.
  • 8. References - Medical textbooks and clinical guidelines. - Reliable journals and articles on gallstone disease. - Imaging and diagnostic studies on cholelithiasis.