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Introduction of sodium cromoglycate
Introduction of sodium cromoglycate
INTRODUCTION:
Sodium Cromoglycate also known as Sodium
Cromoglicate. a synthetic non-steroidal anti-
inflammatory drug, inhaled to prevent asthmatic
attacks and allergic reactions.
Sodium cromoglycate is traditionally described as a
mast cell stabilizer, and is commonly marketed as
the sodium salt, sodium cromoglycate or cromolyn
sodium
Sodium cromoglycate (SCG) was discovered
in1965 by the late Dr. Roger Altounyan (who was
himself a lifelong asthma sufferer)
developed by Fisons Pharmaceuticals for use as
an inhaled drug in asthma, primarily of allergic
origin. The drug was selected after over 200
compounds had been tested by Altounyan
Sodium cromoglycate acts by inhibiting the release of
chemical mediators from sensitized mast cells. It is used in
the prophylactic treatment of both allergic and exercise-
induced asthma, but does not affect an established
asthmatic attack.
Cromolyn sodium probably interferes with the antigen-
stimulated calcium transport across the mast cell
membrane, thereby inhibiting mast cell release of
histamine, leukotrienes, and other substances that cause
hypersensitivity reactions.
BRONCHIAL ASTHMA
ALLERGIC RHINITIS
ALLERGIC CONGUCTIVITUS
AS AN INHALER: (Fintal inhaler)
PREPARATION: 1mg metered dose inhaler.
DOSE: 2 puffs (Q.I.D)
AS A NASAL SPRAY : (Fintal nasal spray)
PREPARATION: 2% aqueous solution
DOSE: 2 squeezes in each nostrils (Q.I.D)
AS EYE DROPS: (Fintal eye drops)
PREPARATION: 2% aqueous solution
DOSE: 1 drop in each eye (Q.I.D)
Skin rashes
Bronchospasm
Throat irritation
dizziness
Flare up of skin
Arthralgia
Sometime urticaria
ABSORPTION: poorly absorbed orally i.e. 0.5% but in
the form of aerosol its absorption rate increased up
to 1.5%
ELIMINATION: most of absorbed drug is excreted
unchanged by liver & kidneys within a few days &
none appears to undergo metabolic degradation.
Introduction of sodium cromoglycate

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Introduction of sodium cromoglycate

  • 3. INTRODUCTION: Sodium Cromoglycate also known as Sodium Cromoglicate. a synthetic non-steroidal anti- inflammatory drug, inhaled to prevent asthmatic attacks and allergic reactions. Sodium cromoglycate is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt, sodium cromoglycate or cromolyn sodium
  • 4. Sodium cromoglycate (SCG) was discovered in1965 by the late Dr. Roger Altounyan (who was himself a lifelong asthma sufferer) developed by Fisons Pharmaceuticals for use as an inhaled drug in asthma, primarily of allergic origin. The drug was selected after over 200 compounds had been tested by Altounyan
  • 5. Sodium cromoglycate acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise- induced asthma, but does not affect an established asthmatic attack. Cromolyn sodium probably interferes with the antigen- stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions.
  • 7. AS AN INHALER: (Fintal inhaler) PREPARATION: 1mg metered dose inhaler. DOSE: 2 puffs (Q.I.D) AS A NASAL SPRAY : (Fintal nasal spray) PREPARATION: 2% aqueous solution DOSE: 2 squeezes in each nostrils (Q.I.D) AS EYE DROPS: (Fintal eye drops) PREPARATION: 2% aqueous solution DOSE: 1 drop in each eye (Q.I.D)
  • 8. Skin rashes Bronchospasm Throat irritation dizziness Flare up of skin Arthralgia Sometime urticaria
  • 9. ABSORPTION: poorly absorbed orally i.e. 0.5% but in the form of aerosol its absorption rate increased up to 1.5% ELIMINATION: most of absorbed drug is excreted unchanged by liver & kidneys within a few days & none appears to undergo metabolic degradation.