IZOLIRANE KRVNE ŽILE
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1. Lymphocyte development involves commitment to the B or T cell lineage, proliferation of progenitors, rearrangement of antigen receptor genes, selection checkpoints, and differentiation into distinct subpopulations.
2. B cells undergo gene rearrangement and development in the bone marrow before migrating to peripheral lymphoid organs. T cells develop through similar processes in the thymus.
3. During development, gene rearrangement generates diversity in antigen receptor genes, and selection checkpoints ensure that only lymphocytes with functional receptors will mature and enter the peripheral immune system.
Basic immunology 1 10
Basic immunology 1 10improvemedThis document provides an overview of basic immunology concepts. It begins with definitions of key immunology terms like immunity, immunology, antigen, and discusses the historical figures Edward Jenner and Louis Pasteur who were pioneers in vaccination. It then discusses the components of the immune system including organs like the bone marrow, thymus, lymph nodes, and spleen. It provides information on cells of the immune system like antigen presenting cells, T and B lymphocytes, and effector cells. It also discusses molecular components of antigen recognition including antibodies, T cell receptors, B cell receptors, and the major histocompatibility complex.
Primjeri upotrebe
Primjeri upotrebeimprovemedDokument se bavi primjenom biomedicinske informatike u ranom otkrivanju raka, predikciji terapijskih odgovora i korištenju dijagnostičkih alata za kronične bolesti. Razvijaju se tehnike poput analize podataka i omics pristupa za poboljšanje dijagnoze i razumijevanja bolesti, uključujući istraživanja ljudskog mikrobioma i inovacije u razvoju cjepiva. Također se razmatraju vremenske analize serija za predviđanje zdravstvenih ishoda, posebno u kontekstu dijabetesa.
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Osnovni tečaj računalnih metoda improvemedDokument opisuje metode rudarenja podataka (data mining) koje kombiniraju umjetnu inteligenciju, strojno učenje i statistiku za analizu velikih skupova podataka, posebno u zdravstvenim znanostima. Istaknute su različite tehnike poput klasteriranja, logističke regresije i umjetnih neuronskih mreža, te njihova primjena u predikciji i klasifikaciji podataka. Također se raspravlja o važnosti vizualizacije podataka za bolje razumijevanje složenosti informacija.
Medicina kao znanost podataka
Medicina kao znanost podatakaimprovemedDokument se fokusira na razvoj biomedicinske informatike i kako veliki podaci transformiraju medicinu putem digitalizacije, analize i nove pristupa personaliziranoj medicini. Ističe izazove s heterogenim podacima, potrebom za integracijom i analizi te važnost znanja koja se može izvući iz tih podataka za poboljšanje zdravstvenih ishoda. Također se raspravlja o ulozi strojnog učenja i metoda otkrivanja podataka u zdravstvenoj praksi.
Notes for Measuring blood flow and reactivity of the blood vessels in the ski...
Notes for Measuring blood flow and reactivity of the blood vessels in the ski...improvemed
Notes for STAINING AND ANALYSIS of HISTOLOGICAL PREPARATIONS
Notes for STAINING AND ANALYSIS of HISTOLOGICAL PREPARATIONSimprovemed
Notes for Fixation of tissues and organs for educational and scientific purposes
Notes for Fixation of tissues and organs for educational and scientific purposesimprovemed
Notes for The principle and performance of capillary electrophoresis
Notes for The principle and performance of capillary electrophoresisimprovemed
Notes for The principle and performance of liquid chromatography–mass spectro...
Notes for The principle and performance of liquid chromatography–mass spectro...improvemed
Systems biology for Medicine' is 'Experimental methods and the big datasets
Systems biology for Medicine' is 'Experimental methods and the big datasetsimprovemed
Systems biology for medical students/Systems medicine
Systems biology for medical students/Systems medicineimprovemed
IZOLIRANE KRVNE ŽILE
- 1. IZOLIRANE KRVNE ŽILE Ivana ܰ쾱ć
- 2. DIJELOVI SUSTAVA I PRINCIP RADA • proučavanje strukture i funkcije izoliranih krvnih žila malih promjera (> 60 μm) - srednje moždane arterije štakora • miogeni odgovor / protokom potaknuta dilatacija • različiti farmakološki / fiziološki podražaji • ugrađeni sustav grijanja • otvori za superfuziju, brzo pražnjenje i punjenje (dodavanje lijekova / oksidacija) • čišćenje i uredno održavanje • Danish Myo Technology (DMT) (Danska) / MyoVIEW • FlowMeter - 161FM • protoka između 15-1500 μL/min
- 3. Slika 1. Dijelovi sustava za izolirane krvne žile (Pressure Myograph System, DMT Model 111P)
- 4. PRIPREMA PSS OTOPINE PSS OTOPINA • Za pripremu 0,5 L : • Destilirana voda: 450 mL • Salt Stock otopina: 25 mL • Buffer Stock otopina: 25 mL • Glukoza: 0,5 g • NaH2PO4: 0,07 g Ca-free PSS OTOPINA • Za pripremu 0,5 L: • Destilirana voda: 450 mL • Salt Stock Ca-free otopina: 25 mL • Buffer Stock Ca-free otopina: 25 mL • Glukoza: 0,5 g • NaH2PO4: 0,07 g pH 7.35 – 7.45
- 5. IZOLACIJA SREDNJE MOŽDANE ARTERIJE • anestezija • ketamin 75 mg/kg i midazolam 0,5 mg/kg • dekapitacija • izolacija arterija • PSS (37C) • kontinuirana oksigenacija sustava • 21% O2, 5% CO2 i balans N2 • inkubacija krvne žile • 60 min / ∆80 mmHg
- 6. EKSPERIMENTALNI PROTOKOL • Bazične vrijednosti • tlačni gradijenti Δ10, Δ20, Δ40, Δ60 i 100 mmHg • prisutnost / odsutnost inhibitora • L-NAME • INDOMETACIN • MSPPOH • TEMPOL • Ach / SNP • Ca2+- free PSS otopina
- 7. STATISTIČKA OBRADA I PRIKAZ PODATAKA • za obradu podataka moramo koristiti two-way ANOVA repeated measures Slika 2. Bazični odgovor otporničkih arteriola potkožnog (SAT) i visceralnog (VAT) masnog tkiva na protokom potaknutu dilataciju (FID), usporedba između 2 grupe