Computational Protein Design. Overview
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This document provides an overview of computational protein design. It discusses challenges in protein engineering like the protein design cycle and screening methods. It also describes computational protein design methods including protein descriptors, sequence-based methods, structure-based methods, and search algorithms. Finally, it outlines applications in systems and synthetic biology such as protein affinity enhancement and modular design.
Computational Protein Design. Overview
- 1. Computational Protein Design Overview Pablo Carbonell pablo.carbonell@issb.genopole.fr iSSB, Institute of Systems and Synthetic Biology Genopole, University dvry-Val dEssonne, France mSSB: December 2010 Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 1/3
- 2. Overview 1 Challenges in Protein Engineering The protein design cycle Types of protein interacions Locating and introducing the substitutions Engineering protein activity Screening and library creation 2 Computational Protein Design Protein descriptors Sequence-based methods Structure-based methods Search algorithms De novo design 3 Applications in Systems and Synthetic Biology Protein af鍖nity enhancement Protein modular design Protein promiscuity reengineering 4 Practical exercise Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 2/3
- 3. Computational Protein Design Overview Pablo Carbonell pablo.carbonell@issb.genopole.fr iSSB, Institute of Systems and Synthetic Biology Genopole, University dvry-Val dEssonne, France mSSB: December 2010 Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 3/3