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Examples of continuous
probability distributions:
The normal and standard normal
The Normal Distribution
X
f(X)
?
?
Changing μ shifts the
distribution left or right.
Changing σ increases or
decreases the spread.
The Normal Distribution:
as mathematical function
(pdf)
2
)
(
2
1
2
1
)
( ?
?
?
?
?
?
?
?
x
e
x
f
Note constants:
?=3.14159
e=2.71828
This is a bell shaped
curve with different
centers and spreads
depending on ? and ?
The Normal PDF
1
2
1 2
)
(
2
1
?
?
?
??
?
?
?
?
dx
e
x
?
?
?
?
It’s a probability function, so no matter what the values
of ? and ?, must integrate to 1!
Normal distribution is defined
by its mean and standard dev.
E(X)=? =
Var(X)=?2 =
Standard Deviation(X)=?
dx
e
x
x
?
??
?
?
?
?
?
2
)
(
2
1
2
1 ?
?
?
?
2
)
(
2
1
2
)
2
1
(
2
?
?
?
?
?
?
?
?
??
?
?
?
?
dx
e
x
x
**The beauty of the normal curve:
No matter what ? and ? are, the area between ?-? and
?+? is about 68%; the area between ?-2? and ?+2? is
about 95%; and the area between ?-3? and ?+3? is
about 99.7%. Almost all values fall within 3 standard
deviations.
68-95-99.7 Rule
68% of
the data
95% of the data
99.7% of the data
68-95-99.7 Rule
in Math terms…
997
.
2
1
95
.
2
1
68
.
2
1
3
3
)
(
2
1
2
2
)
(
2
1
)
(
2
1
2
2
2
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
?
dx
e
dx
e
dx
e
x
x
x
How good is rule for real data?
Check some example data:
The mean of the weight of the women = 127.8
The standard deviation (SD) = 15.5
8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0
0
5
1 0
1 5
2 0
2 5
P
e
r
c
e
n
t
P O U N D S
127.8 143.3
112.3
68% of 120 = .68x120 = ~ 82 runners
In fact, 79 runners fall within 1-SD (15.5 lbs) of the mean.
8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0
0
5
1 0
1 5
2 0
2 5
P
e
r
c
e
n
t
P O U N D S
127.8
96.8
95% of 120 = .95 x 120 = ~ 114 runners
In fact, 115 runners fall within 2-SD’s of the mean.
158.8
8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0
0
5
1 0
1 5
2 0
2 5
P
e
r
c
e
n
t
P O U N D S
127.8
81.3
99.7% of 120 = .997 x 120 = 119.6 runners
In fact, all 120 runners fall within 3-SD’s of the mean.
174.3
Example
? Suppose SAT scores roughly follows a
normal distribution in the U.S. population of
college-bound students (with range
restricted to 200-800), and the average math
SAT is 500 with a standard deviation of 50,
then:
? 68% of students will have scores between 450
and 550
? 95% will be between 400 and 600
? 99.7% will be between 350 and 650
Example
? BUT…
? What if you wanted to know the math SAT
score corresponding to the 90th percentile
(=90% of students are lower)?
P(X≤Q) = .90 ?
90
.
2
)
50
(
1
200
)
50
500
(
2
1 2
?
?
?
?
?
Q x
dx
e
?
Solve for Q?….Yikes!
The Standard Normal (Z):
“Universal Currency”
The formula for the standardized normal
probability density function is
2
2
)
(
2
1
)
1
0
(
2
1
2
1
2
)
1
(
1
)
(
Z
Z
e
e
Z
p
?
?
?
?
?
?
?
?
?
The Standard Normal Distribution (Z)
All normal distributions can be converted into
the standard normal curve by subtracting the
mean and dividing by the standard deviation:
?
?
?
?
X
Z
Somebody calculated all the integrals for the standard
normal and put them in a table! So we never have to
integrate!
Even better, computers now do all the integration.
Comparing X and Z units
Z
100
2.0
0
200 X (? = 100, ? = 50)
(? = 0, ? = 1)
Example
? For example: What’s the probability of getting a math SAT
score of 575 or less, ?=500 and ?=50?
5
.
1
50
500
575
?
?
?
Z
?i.e., A score of 575 is 1.5 standard deviations above the mean
?
? ?
?
?
?
?
?
??
?
?
?
?
?
5
.
1
2
1
575
200
)
50
500
(
2
1 2
2
2
1
2
)
50
(
1
)
575
( dz
e
dx
e
X
P
Z
x
?
?
Yikes!
But to look up Z= 1.5 in standard normal chart (or enter
into SAS)? no problem! = .9332
Practice problem
If birth weights in a population are
normally distributed with a mean of 109
oz and a standard deviation of 13 oz,
a. What is the chance of obtaining a birth
weight of 141 oz or heavier when
sampling birth records at random?
b. What is the chance of obtaining a birth
weight of 120 or lighter?
Answer
a. What is the chance of obtaining a birth
weight of 141 oz or heavier when
sampling birth records at random?
46
.
2
13
109
141
?
?
?
Z
From the chart or SAS ? Z of 2.46 corresponds to a right tail (greater
than) area of: P(Z≥2.46) = 1-(.9931)= .0069 or .69 %
Answer
b. What is the chance of obtaining a birth
weight of 120 or lighter?
From the chart or SAS ? Z of .85 corresponds to a left tail area of:
P(Z≤.85) = .8023= 80.23%
85
.
13
109
120
?
?
?
Z
Looking up probabilities in the
standard normal table
What is the area to the
left of Z=1.51 in a
standard normal curve?
Z=1.51
Z=1.51
Area is 93.45%
Normal probabilities in SAS
data _null_;
theArea=probnorm(1.5);
put theArea;
run;
0.9331927987
And if you wanted to go the other direction (i.e., from the area to the Z
score (called the so-called “Probit” function?
data _null_;
theZValue=probit(.93);
put theZValue;
run;
1.4757910282
The “probnorm(Z)” function gives you
the probability from negative infinity to
Z (here 1.5) in a standard normal curve.
The “probit(p)” function gives you the
Z-value that corresponds to a left-tail
area of p (here .93) from a standard
normal curve. The probit function is also
known as the inverse standard normal
function.
Probit function: the inverse
?(area)= Z: gives the Z-value that goes with the probability you want
For example, recall SAT math scores example. What’s the score that
corresponds to the 90th percentile?
In Table, find the Z-value that corresponds to area of .90 ? Z= 1.28
Or use SAS
data _null_;
theZValue=probit(.90);
put theZValue;
run;
1.2815515655
If Z=1.28, convert back to raw SAT score ?
1.28 =
X – 500 =1.28 (50)
X=1.28(50) + 500 = 564 (1.28 standard deviations above the mean!)
`
50
500
?
X
Are my data “normal”?
? Not all continuous random variables are
normally distributed!!
? It is important to evaluate how well the
data are approximated by a normal
distribution
Are my data normally
distributed?
1. Look at the histogram! Does it appear bell
shaped?
2. Compute descriptive summary measures—are
mean, median, and mode similar?
3. Do 2/3 of observations lie within 1 std dev of
the mean? Do 95% of observations lie within
2 std dev of the mean?
4. Look at a normal probability plot—is it
approximately linear?
5. Run tests of normality (such as Kolmogorov-
Smirnov). But, be cautious, highly influenced
by sample size!
Data from our class…
Median = 6
Mean = 7.1
Mode = 0
SD = 6.8
Range = 0 to 24
(= 3.5 ?)
Data from our class…
Median = 5
Mean = 5.4
Mode = none
SD = 1.8
Range = 2 to 9
(~ 4 ?)
Data from our class…
Median = 3
Mean = 3.4
Mode = 3
SD = 2.5
Range = 0 to 12
(~ 5 ?)
Data from our class…
Median = 7:00
Mean = 7:04
Mode = 7:00
SD = :55
Range = 5:30 to 9:00
(~4 ?)
Data from our class…
7.1 +/- 6.8 =
0.3 – 13.9
0.3 13.9
Data from our class…
7.1 +/- 2*6.8 =
0 – 20.7
Data from our class…
7.1 +/- 3*6.8 =
0 – 27.5
Data from our class…
5.4 +/- 1.8 =
3.6 – 7.2
3.6 7.2
Data from our class…
5.4 +/- 2*1.8 =
1.8 – 9.0
1.8 9.0
Data from our class…
5.4 +/- 3*1.8 =
0– 10
0 10
Data from our class…
3.4 +/- 2.5=
0.9 – 7.9
0.9 5.9
Data from our class…
3.4 +/- 2*2.5=
0 – 8.4
0 8.4
Data from our class…
3.4 +/- 3*2.5=
0 – 10.9
0 10.9
Data from our class…
7:04+/- 0:55 =
6:09 – 7:59
6:09 7:59
Data from our class…
7:04+/- 2*0:55
=
5:14 – 8:54
5:14
8:54
Data from our class…
7:04+/- 2*0:55
=
4:19 – 9:49
4:19
9:49
The Normal Probability Plot
? Normal probability plot
? Order the data.
? Find corresponding standardized normal quantile
values:
? Plot the observed data values against normal
quantile values.
? Evaluate the plot for evidence of linearity.
area
tail
-
left
particular
a
to
s
correspond
that
value
Z
the
gives
which
function,
probit
the
is
where
)
1
n
i
(
quantile
?
?
?
?
th
i
Normal probability plot
coffee…
Right-Skewed!
(concave up)
Normal probability plot love of
writing…
Neither right-skewed
or left-skewed, but
big gap at 6.
Norm prob. plot Exercise…
Right-Skewed!
(concave up)
Norm prob. plot Wake up time
Closest to a
straight line…
Formal tests for normality
? Results:
? Coffee: Strong evidence of non-normality
(p<.01)
? Writing love: Moderate evidence of non-
normality (p=.01)
? Exercise: Weak to no evidence of non-
normality (p>.10)
? Wakeup time: No evidence of non-normality
(p>.25)
Normal approximation to the
binomial
When you have a binomial distribution where n is
large and p is middle-of-the road (not too small, not
too big, closer to .5), then the binomial starts to look
like a normal distribution? in fact, this doesn’t even
take a particularly large n?
Recall: What is the probability of being a smoker among
a group of cases with lung cancer is .6, what’s the
probability that in a group of 8 cases you have less
than 2 smokers?
Normal approximation to the
binomial
When you have a binomial distribution where
n is large and p isn’t too small (rule of thumb:
mean>5), then the binomial starts to look like
a normal distribution?
Recall: smoking example…
1 4 5
2 3 6 7 8
0
.27 Starting to have a normal
shape even with fairly small
n. You can imagine that if n
got larger, the bars would get
thinner and thinner and this
would look more and more
like a continuous function,
with a bell curve shape. Here
np=4.8.
Normal approximation to
binomial
1 4 5
2 3 6 7 8
0
.27
What is the probability of fewer than 2 smokers?
Normal approximation probability:
?=4.8
?=1.39
2
39
.
1
8
.
2
39
.
1
)
8
.
4
(
2
?
?
?
?
?
?
Z
Exact binomial probability (from before) = .00065 + .008 = .00865
P(Z<2)=.022
A little off, but in the right ballpark… we could also use the value
to the left of 1.5 (as we really wanted to know less than but not
including 2; called the “continuity correction”)…
37
.
2
39
.
1
3
.
3
39
.
1
)
8
.
4
(
5
.
1
?
?
?
?
?
?
Z
P(Z≤-2.37) =.0069
A fairly good approximation of
the exact probability, .00865.
Practice problem
1. You are performing a cohort study. If the probability
of developing disease in the exposed group is .25 for
the study duration, then if you sample (randomly)
500 exposed people, What’s the probability that at
most 120 people develop the disease?
Answer
P(Z<-.52)= .3015
52
.
68
.
9
125
120
?
?
?
?
Z
500
0
500
0
)
75
(.
)
25
(.
?
?
?
?
?
?
499
1
500
1
)
75
(.
)
25
(.
?
?
?
?
?
?
498
2
500
2
)
75
(.
)
25
(.
?
?
?
?
?
?
380
120
500
120
)
75
(.
)
25
(.
?
?
?
?
?
?
+ + + …
By hand (yikes!):
P(X≤120) = P(X=0) + P(X=1) + P(X=2) + P(X=3) + P(X=4)+….+ P(X=120)=
OR Use SAS:
data _null_;
Cohort=cdf('binomial', 120, .25, 500);
put Cohort;
run;
0.323504227
OR use, normal approximation:
?=np=500(.25)=125 and ?2=np(1-p)=93.75; ?=9.68
Proportions…
? The binomial distribution forms the basis of
statistics for proportions.
? A proportion is just a binomial count divided
by n.
? For example, if we sample 200 cases and find 60
smokers, X=60 but the observed proportion=.30.
? Statistics for proportions are similar to
binomial counts, but differ by a factor of n.
Stats for proportions
For binomial:
)
1
(
)
1
(
2
p
np
p
np
np
x
x
x
?
?
?
?
?
?
?
?
For proportion:
n
p
p
n
p
p
n
p
np
p
p
p
p
)
1
(
)
1
(
)
1
(
?
2
2
?
?
?
?
?
?
?
?
?
?
?
?
P-hat stands for “sample
proportion.”
Differs by
a factor of
n.
Differs
by a
factor
of n.
It all comes back to Z…
? Statistics for proportions are based on a
normal distribution, because the
binomial can be approximated as
normal if np>5

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lecture6.ppt

  • 1. Examples of continuous probability distributions: The normal and standard normal
  • 2. The Normal Distribution X f(X) ? ? Changing μ shifts the distribution left or right. Changing σ increases or decreases the spread.
  • 3. The Normal Distribution: as mathematical function (pdf) 2 ) ( 2 1 2 1 ) ( ? ? ? ? ? ? ? ? x e x f Note constants: ?=3.14159 e=2.71828 This is a bell shaped curve with different centers and spreads depending on ? and ?
  • 4. The Normal PDF 1 2 1 2 ) ( 2 1 ? ? ? ?? ? ? ? ? dx e x ? ? ? ? It’s a probability function, so no matter what the values of ? and ?, must integrate to 1!
  • 5. Normal distribution is defined by its mean and standard dev. E(X)=? = Var(X)=?2 = Standard Deviation(X)=? dx e x x ? ?? ? ? ? ? ? 2 ) ( 2 1 2 1 ? ? ? ? 2 ) ( 2 1 2 ) 2 1 ( 2 ? ? ? ? ? ? ? ? ?? ? ? ? ? dx e x x
  • 6. **The beauty of the normal curve: No matter what ? and ? are, the area between ?-? and ?+? is about 68%; the area between ?-2? and ?+2? is about 95%; and the area between ?-3? and ?+3? is about 99.7%. Almost all values fall within 3 standard deviations.
  • 7. 68-95-99.7 Rule 68% of the data 95% of the data 99.7% of the data
  • 8. 68-95-99.7 Rule in Math terms… 997 . 2 1 95 . 2 1 68 . 2 1 3 3 ) ( 2 1 2 2 ) ( 2 1 ) ( 2 1 2 2 2 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? dx e dx e dx e x x x
  • 9. How good is rule for real data? Check some example data: The mean of the weight of the women = 127.8 The standard deviation (SD) = 15.5
  • 10. 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 0 5 1 0 1 5 2 0 2 5 P e r c e n t P O U N D S 127.8 143.3 112.3 68% of 120 = .68x120 = ~ 82 runners In fact, 79 runners fall within 1-SD (15.5 lbs) of the mean.
  • 11. 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 0 5 1 0 1 5 2 0 2 5 P e r c e n t P O U N D S 127.8 96.8 95% of 120 = .95 x 120 = ~ 114 runners In fact, 115 runners fall within 2-SD’s of the mean. 158.8
  • 12. 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 0 5 1 0 1 5 2 0 2 5 P e r c e n t P O U N D S 127.8 81.3 99.7% of 120 = .997 x 120 = 119.6 runners In fact, all 120 runners fall within 3-SD’s of the mean. 174.3
  • 13. Example ? Suppose SAT scores roughly follows a normal distribution in the U.S. population of college-bound students (with range restricted to 200-800), and the average math SAT is 500 with a standard deviation of 50, then: ? 68% of students will have scores between 450 and 550 ? 95% will be between 400 and 600 ? 99.7% will be between 350 and 650
  • 14. Example ? BUT… ? What if you wanted to know the math SAT score corresponding to the 90th percentile (=90% of students are lower)? P(X≤Q) = .90 ? 90 . 2 ) 50 ( 1 200 ) 50 500 ( 2 1 2 ? ? ? ? ? Q x dx e ? Solve for Q?….Yikes!
  • 15. The Standard Normal (Z): “Universal Currency” The formula for the standardized normal probability density function is 2 2 ) ( 2 1 ) 1 0 ( 2 1 2 1 2 ) 1 ( 1 ) ( Z Z e e Z p ? ? ? ? ? ? ? ? ?
  • 16. The Standard Normal Distribution (Z) All normal distributions can be converted into the standard normal curve by subtracting the mean and dividing by the standard deviation: ? ? ? ? X Z Somebody calculated all the integrals for the standard normal and put them in a table! So we never have to integrate! Even better, computers now do all the integration.
  • 17. Comparing X and Z units Z 100 2.0 0 200 X (? = 100, ? = 50) (? = 0, ? = 1)
  • 18. Example ? For example: What’s the probability of getting a math SAT score of 575 or less, ?=500 and ?=50? 5 . 1 50 500 575 ? ? ? Z ?i.e., A score of 575 is 1.5 standard deviations above the mean ? ? ? ? ? ? ? ? ?? ? ? ? ? ? 5 . 1 2 1 575 200 ) 50 500 ( 2 1 2 2 2 1 2 ) 50 ( 1 ) 575 ( dz e dx e X P Z x ? ? Yikes! But to look up Z= 1.5 in standard normal chart (or enter into SAS)? no problem! = .9332
  • 19. Practice problem If birth weights in a population are normally distributed with a mean of 109 oz and a standard deviation of 13 oz, a. What is the chance of obtaining a birth weight of 141 oz or heavier when sampling birth records at random? b. What is the chance of obtaining a birth weight of 120 or lighter?
  • 20. Answer a. What is the chance of obtaining a birth weight of 141 oz or heavier when sampling birth records at random? 46 . 2 13 109 141 ? ? ? Z From the chart or SAS ? Z of 2.46 corresponds to a right tail (greater than) area of: P(Z≥2.46) = 1-(.9931)= .0069 or .69 %
  • 21. Answer b. What is the chance of obtaining a birth weight of 120 or lighter? From the chart or SAS ? Z of .85 corresponds to a left tail area of: P(Z≤.85) = .8023= 80.23% 85 . 13 109 120 ? ? ? Z
  • 22. Looking up probabilities in the standard normal table What is the area to the left of Z=1.51 in a standard normal curve? Z=1.51 Z=1.51 Area is 93.45%
  • 23. Normal probabilities in SAS data _null_; theArea=probnorm(1.5); put theArea; run; 0.9331927987 And if you wanted to go the other direction (i.e., from the area to the Z score (called the so-called “Probit” function? data _null_; theZValue=probit(.93); put theZValue; run; 1.4757910282 The “probnorm(Z)” function gives you the probability from negative infinity to Z (here 1.5) in a standard normal curve. The “probit(p)” function gives you the Z-value that corresponds to a left-tail area of p (here .93) from a standard normal curve. The probit function is also known as the inverse standard normal function.
  • 24. Probit function: the inverse ?(area)= Z: gives the Z-value that goes with the probability you want For example, recall SAT math scores example. What’s the score that corresponds to the 90th percentile? In Table, find the Z-value that corresponds to area of .90 ? Z= 1.28 Or use SAS data _null_; theZValue=probit(.90); put theZValue; run; 1.2815515655 If Z=1.28, convert back to raw SAT score ? 1.28 = X – 500 =1.28 (50) X=1.28(50) + 500 = 564 (1.28 standard deviations above the mean!) ` 50 500 ? X
  • 25. Are my data “normal”? ? Not all continuous random variables are normally distributed!! ? It is important to evaluate how well the data are approximated by a normal distribution
  • 26. Are my data normally distributed? 1. Look at the histogram! Does it appear bell shaped? 2. Compute descriptive summary measures—are mean, median, and mode similar? 3. Do 2/3 of observations lie within 1 std dev of the mean? Do 95% of observations lie within 2 std dev of the mean? 4. Look at a normal probability plot—is it approximately linear? 5. Run tests of normality (such as Kolmogorov- Smirnov). But, be cautious, highly influenced by sample size!
  • 27. Data from our class… Median = 6 Mean = 7.1 Mode = 0 SD = 6.8 Range = 0 to 24 (= 3.5 ?)
  • 28. Data from our class… Median = 5 Mean = 5.4 Mode = none SD = 1.8 Range = 2 to 9 (~ 4 ?)
  • 29. Data from our class… Median = 3 Mean = 3.4 Mode = 3 SD = 2.5 Range = 0 to 12 (~ 5 ?)
  • 30. Data from our class… Median = 7:00 Mean = 7:04 Mode = 7:00 SD = :55 Range = 5:30 to 9:00 (~4 ?)
  • 31. Data from our class… 7.1 +/- 6.8 = 0.3 – 13.9 0.3 13.9
  • 32. Data from our class… 7.1 +/- 2*6.8 = 0 – 20.7
  • 33. Data from our class… 7.1 +/- 3*6.8 = 0 – 27.5
  • 34. Data from our class… 5.4 +/- 1.8 = 3.6 – 7.2 3.6 7.2
  • 35. Data from our class… 5.4 +/- 2*1.8 = 1.8 – 9.0 1.8 9.0
  • 36. Data from our class… 5.4 +/- 3*1.8 = 0– 10 0 10
  • 37. Data from our class… 3.4 +/- 2.5= 0.9 – 7.9 0.9 5.9
  • 38. Data from our class… 3.4 +/- 2*2.5= 0 – 8.4 0 8.4
  • 39. Data from our class… 3.4 +/- 3*2.5= 0 – 10.9 0 10.9
  • 40. Data from our class… 7:04+/- 0:55 = 6:09 – 7:59 6:09 7:59
  • 41. Data from our class… 7:04+/- 2*0:55 = 5:14 – 8:54 5:14 8:54
  • 42. Data from our class… 7:04+/- 2*0:55 = 4:19 – 9:49 4:19 9:49
  • 43. The Normal Probability Plot ? Normal probability plot ? Order the data. ? Find corresponding standardized normal quantile values: ? Plot the observed data values against normal quantile values. ? Evaluate the plot for evidence of linearity. area tail - left particular a to s correspond that value Z the gives which function, probit the is where ) 1 n i ( quantile ? ? ? ? th i
  • 45. Normal probability plot love of writing… Neither right-skewed or left-skewed, but big gap at 6.
  • 46. Norm prob. plot Exercise… Right-Skewed! (concave up)
  • 47. Norm prob. plot Wake up time Closest to a straight line…
  • 48. Formal tests for normality ? Results: ? Coffee: Strong evidence of non-normality (p<.01) ? Writing love: Moderate evidence of non- normality (p=.01) ? Exercise: Weak to no evidence of non- normality (p>.10) ? Wakeup time: No evidence of non-normality (p>.25)
  • 49. Normal approximation to the binomial When you have a binomial distribution where n is large and p is middle-of-the road (not too small, not too big, closer to .5), then the binomial starts to look like a normal distribution? in fact, this doesn’t even take a particularly large n? Recall: What is the probability of being a smoker among a group of cases with lung cancer is .6, what’s the probability that in a group of 8 cases you have less than 2 smokers?
  • 50. Normal approximation to the binomial When you have a binomial distribution where n is large and p isn’t too small (rule of thumb: mean>5), then the binomial starts to look like a normal distribution? Recall: smoking example… 1 4 5 2 3 6 7 8 0 .27 Starting to have a normal shape even with fairly small n. You can imagine that if n got larger, the bars would get thinner and thinner and this would look more and more like a continuous function, with a bell curve shape. Here np=4.8.
  • 51. Normal approximation to binomial 1 4 5 2 3 6 7 8 0 .27 What is the probability of fewer than 2 smokers? Normal approximation probability: ?=4.8 ?=1.39 2 39 . 1 8 . 2 39 . 1 ) 8 . 4 ( 2 ? ? ? ? ? ? Z Exact binomial probability (from before) = .00065 + .008 = .00865 P(Z<2)=.022
  • 52. A little off, but in the right ballpark… we could also use the value to the left of 1.5 (as we really wanted to know less than but not including 2; called the “continuity correction”)… 37 . 2 39 . 1 3 . 3 39 . 1 ) 8 . 4 ( 5 . 1 ? ? ? ? ? ? Z P(Z≤-2.37) =.0069 A fairly good approximation of the exact probability, .00865.
  • 53. Practice problem 1. You are performing a cohort study. If the probability of developing disease in the exposed group is .25 for the study duration, then if you sample (randomly) 500 exposed people, What’s the probability that at most 120 people develop the disease?
  • 54. Answer P(Z<-.52)= .3015 52 . 68 . 9 125 120 ? ? ? ? Z 500 0 500 0 ) 75 (. ) 25 (. ? ? ? ? ? ? 499 1 500 1 ) 75 (. ) 25 (. ? ? ? ? ? ? 498 2 500 2 ) 75 (. ) 25 (. ? ? ? ? ? ? 380 120 500 120 ) 75 (. ) 25 (. ? ? ? ? ? ? + + + … By hand (yikes!): P(X≤120) = P(X=0) + P(X=1) + P(X=2) + P(X=3) + P(X=4)+….+ P(X=120)= OR Use SAS: data _null_; Cohort=cdf('binomial', 120, .25, 500); put Cohort; run; 0.323504227 OR use, normal approximation: ?=np=500(.25)=125 and ?2=np(1-p)=93.75; ?=9.68
  • 55. Proportions… ? The binomial distribution forms the basis of statistics for proportions. ? A proportion is just a binomial count divided by n. ? For example, if we sample 200 cases and find 60 smokers, X=60 but the observed proportion=.30. ? Statistics for proportions are similar to binomial counts, but differ by a factor of n.
  • 56. Stats for proportions For binomial: ) 1 ( ) 1 ( 2 p np p np np x x x ? ? ? ? ? ? ? ? For proportion: n p p n p p n p np p p p p ) 1 ( ) 1 ( ) 1 ( ? 2 2 ? ? ? ? ? ? ? ? ? ? ? ? P-hat stands for “sample proportion.” Differs by a factor of n. Differs by a factor of n.
  • 57. It all comes back to Z… ? Statistics for proportions are based on a normal distribution, because the binomial can be approximated as normal if np>5