More Related Content
What's hot (20)
Similar to Niosomes presentation (20)
Recently uploaded (20)
Niosomes presentation
- 1. Presented by Under The Guidance Khan Ramiz V Prof. S. Talele M. Pharm (1st year) M.Pharm Dept. of Pharmaceutics SIPS 1
- 2. CONTENTS Introduction Classification Niosomes Definition of Niosomes Types of Niosomes Method of preparation Advantages and disadvantages application 2
- 3. INTRODUCTION NOVEL DRUG DELIVERY SYSTEM (NDDS) It refers to approaches, formulation, technologies, and system for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Technologies modify drug release profile, absorption, distribution and elimination for the benefit of a) improving product efficacy and safety b) patient convenience and compliance. 3
- 4. Classification Niosomes Nanoparticals Liposomes Microspheres Monoclonal antibodies Micro emulsions Magnetic microcapsules Implantable pumps 4
- 5. NIOSOMES Novel drug delivery system, in which the medication is encapsulated in a vesicle which is composed of a bilayer of non-surface active agents. It is very small, and microscopic in size. Although structurally similar to liposomes, they offer several advantages over them. Similar to liposomes , in that they are also made up of a bilayer. 5
- 6. WHY ? WHY ? WHY ? Used for a variety of drug : accommodate hydrophilic, lipophilic as well as amphiphilic moieties. Act as a depot to release the drug slowly and offer a controlled release. Osmotically acative and stable Increase the stability of the entrapped drug Handling and storage of surfactants do not require any special conditions Enhance the skin penetration of drugs 6
- 7. 7
- 9. TYPES OF NIOSOMES According to the nature of lamellarity 1. Multilamellar vesicles (MLV) 1-5 袖m in size. 2. Large Unilamellar vesicles (LUV) 0.1-1袖m in size. 3. Small Unilamellar vesicles (SUV) 25-500 nm in size. According to the size 1. Small Niosomes (100 nm-200 nm) 2. Large Niosomes (800 nm-900 nm) 3. Big Niosomes (2 袖m-4 袖m) 9
- 10. 10
- 11. METHODS OF PREPARATION Film Method Ether Injection method Sonication Reverse Phase Evaporation Heating Method Microfluidization Multiple Membrane Extrusion Method 11
- 12. FILM METHOD Also known as hand shaking method Take a mixture of surfactant and cholesterol Dissolved in an organic solvent in a round bottomed flask. (eg. Diethyl ether, chloroform,etc) organic solvent is removed by low pressure/vaccume at room temperature.(by using rotary evaporator) The resultant dry surfactant film is dehydrated by agitation at 50-60C multilamellar vesicle (MLV) are formed. 12
- 13. ETHER INJECTION METHOD Introduce a solution of surfactant dissolved in diethyl ether into warm water maintained at 60 C. Surfactant mixture in ether is injected through 14-guage needle into an aqueous solution of material. Vaporization of ether leads to formation of single layerd vesicle. Depending upon the conditions used, the diameter of the vesicle range from 50 to 1000nm 13
- 14. sonication Aliquot of drug solution in buffer is added to the surfactant/cholesterol mixture in a 10-ml glass vial Mixture is probe sonicated at 60 C for 3 minute using a sonicater with a titanium probe to yield niosomes 14
- 15. MULTIPLE MEMBRANE EXTRUSION METHOD Mixture of surfactant, cholesterol and dicetyl phophate in chloroform is made into thin film by evaporation The film is hydrated with aqueos drug solution and the resultant suspension extruded through polycarbonate membranes 15
- 16. Reverse phase evaporation tachniques Cholesterol and surfactant (1:1) dissolved in a mixture of ether and chloroform. An aqueous phase containing drug is added to this and the resulting two phase are sonicated at 4-5 C. Organic phase is removed at 40 C under low pressure The resulting viscous niosomes suspension is diluted with PBS and heated on a water at 60 C for 10 min to yield niosomes. 16
- 17. ADVANTAGES Since the structure of the niosomes offers place to accommodate hydrophilic, lipophilic as well as ampiphilic drug moieties, they can be used for a varietey of drug. The vesicles can act as a depot to release the drug slowely and of controlled release. Biodegradable and biocompatible. DISADVANTAGES Time consuming . Required specialized equipment . Inefficient drug loading. Aqueous suspension of niosomes may exihibit fusion, aggregation, leaching of entrapped drug. 17
- 18. APPLICATION Noisomes as Drug Carriers Drug Targeting a) delivery to the brain b) Anti cancer drug c) Anti infection Ophthalmic drug delivery Transdermal delivery of drugs by Niosomes Sustained Release Localized drug action 18
- 19. References The theory & practical of industrial pharmacy by Leon Lachman, Herbert A. Lieberman, Joseph L. kening, 3rd edition, published by Varghese Publishing house, page no 872 19
- 20. THANK YOU 20