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Labor is a complex process that
ultimately
results in the expulsion of the
fetus and placenta
through the birth canal.
Phases of labor
Phase 1: Quiescent phase
Phase 2: Activation phase
Phase 3: Stimulation phase
Phase 4: Involution phase
Phase 1
Features
 Unresponsive myometrium
 Cervical softening-due to inc vascularity, stromal
and glandular hypertrophy- hegar
 Changes in the matrix
 Changes in collagen
Mediators :
 Progesterone
 Relaxin
 Prostaglandin I2
 Nitric oxide
 PTH-RP
 This phase normally comprises 95
percent of pregnancy and is
characterized by uterine smooth
muscle tranquility with
maintenance of cervical structural
integrity.
 Some low-intensity myometrial
contractions are felt during the
quiescent phase, but they do not
normally cause cervical
dilatation. Contractions of this
type become more common
toward the end of pregnancy,
especially in multiparous women,
and are referred to as Braxton
PHASE 2  parturition cascade
The activation phase begins about 68
weeks before term and ends with the
onset of regular uterine contractions.
Changes in the myometrium and cervix
that are essential to this phase are
regulated by the fetal hypothalamo
pituitaryadrenal axis, maternal
hypothalamopituitaryaxis, and
placental endocrine/paracrine factors.
 lead to increased uterine irritability
and responsiveness to uterotonins
agents that stimulate contractions.
 formation of the lower uterine
segment from the isthmus - the fetal
head often descends to or even
through the pelvic inletso-called
lightening.
FEATURES AND MEDIATORS
Changes in the myometrium
 Increase in contractility
 Increase in uterine responsiveness
 Increase in gap junctions
Changes in the cervix
- Cervical ripening
 Changes in collagen structure
 Increase in collagen solubility
 Infiltration by inflammatory cells
 Estrogen
 Progesterone
 CAPs  OXY Rreceptors,pg F rep,
connexin 43 [ gap jn pro]
 Glycosaminogly-cans
 Proteoglycans
 pCRH
 Prostaglandins
 Cortisol
 Interleukin-8
 MMP
Cervical ripening
 The cervix must undergo more
extensive remodeling - eventually
leading to cervical yielding and
dilatation upon initiation of forceful
uterine contractions
 principally involve connective tissue
changes proteoglycans,
glycosaminoglycans -cervical
ripening.
 Many of the processes that aid
cervical remodeling are controlled by
the same hormones regulating
uterine function
 The uterine corpus is predominantly
smooth muscle, whereas the cervix is
primarily connective tissue. Cellular
components of the cervix include
fibroblasts, epithelia, and few smooth
muscle cells.
Fetus in cascade
 activation of the fetal hypothalamic
pituitaryadrenal axis
 Fetal CRH ACTH  DHEAS 17 OH
DHEAS BY FETAL LIVER-- ESTRIOL BY
PLACENTA- PGF2 .= OXY REC, PG
REC, GAP JN,
 FETAL ADRENAL-FETAL CORTISOL 
PG , OXY BY PLA .
 ANENCEPALY
 FETAL ADRENAL HYPOPLASIA
PLACENTAL ROLE
 The placenta actively participates
in the process of labor through the
production of estrogens,
progesterone, placental
corticotropin releasing hormone
and other substances
 PLACENTAL SULFATASE
DEFICIENCY  X LINKED DIS
prevents conversion of sulphated
estrogen precursors.
 Estrogens
 Alter estrogen: Progesterone receptor ratio
 Stimulate production of CAPs by placenta
 Cause uterine contraction
 Progesterone
Causes uterine quiescence
ANTIINFLAMMATORY EFF ON MYOMETRIUM
Undergoes functional withdrawal at term
 Placental corticotropin-releasing hormone
(pCRH)
FETAL CORTISOL- Pcrh- ACTH and DHEAS- PG,
OXYTOCIN
MOTHER ROLE
 OXYTOCIN
FETAL PIT, PLACENTA
NO RISE AS SUCH
Oxy receptors inc (100 -200) , inc in
myometrial sensitivity to oxy
Pg in decidua and membranes
 PG
 Fetal membranes and decidua
contain phos-pholipase and
cyclooxygenase enzymes. They are
activated by local inflammatory
reaction, trauma,stretch, estrogens,
and progesterone.
The increase in oxytocin and PG receptors in the
myometrium plays a key role in uterine contractions.
calcium influx to hormonal stimuli is the most important event
in the initiation of contractions. Myometrial contraction during
the parturition cascade is through actin and myosin
interaction and interaction between myometrial cells
via gap junctions.
Phase 3  stimulation phase- labor
 I STAGE - stage of cervical effacement
and dilatation.
 extrusion of the mucus plug that had
previously filled the cervical canal
during pregnancy is referred to as
show or bloody show.
 Mechanical stretching of cx  uterine
activity  ferguson reflex
 the upper segment contracts, retracts,
and expels the fetus
PAINFUL SMOOTH MSL CONTRACTION:
1) hypoxia of the contracted
myometriumsuch as that with angina
pectoris;
(2) compression of nerve ganglia in the
cervix and lower uterus by contracted
interlocking muscle bundles;
(3) cervical stretching during dilatation;
and
(4) stretching of the peritoneum overlying
the fundus.
The passive lower uterine segment is derived from the isthmus,
and the physiological retraction ring develops at the junction of
the upper and lower uterine segments.
As a result of the lower segment thinning and concomitant upper
segment thickening, a boundary between the two is marked by a
ridge on the inner uterine surfacethe physiological retraction
ring. When the thinning of the lower uterine segment is extreme,
as in obstructed labor, the ring is prominent and forms a
Cervical effacement
 obliteration or taking up of the
cervix. I
 it is manifest clinically by shortening of
the cervical canal from a length of
approximately 2 cm to a mere circular
orifice with almost paper-thin edges.
 The muscular fibers at the level of the
internal cervical os are pulled upward, or
taken up, into the lower uterine
segment.
Cervical dilatation  II stage
III STAGE
 This sudden diminution in uterine
size is inevitably accompanied by a
decrease in the area of the placental
implantation site
 For the placenta to accommodate
itself to this reduced area, it increases
in thickness, but because of limited
placental elasticity, it is forced to
buckle. The resulting tension pulls
the weakest layerdecidua
spongiosafrom that site.
Phase 4  involution phase
Features
 Involution of uterus and cervix
 Responsiveness of endometrium to
ovarian hormones
Mediators :
Oxytocin
Local factors
 Phase 4 or involution phase is known
as the puerperium. The uterus and
cervix return to the prepregnant state
during this phase.
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physiology of labour.pptx

  • 1. Labor is a complex process that ultimately results in the expulsion of the fetus and placenta through the birth canal.
  • 2. Phases of labor Phase 1: Quiescent phase Phase 2: Activation phase Phase 3: Stimulation phase Phase 4: Involution phase
  • 3. Phase 1 Features Unresponsive myometrium Cervical softening-due to inc vascularity, stromal and glandular hypertrophy- hegar Changes in the matrix Changes in collagen Mediators : Progesterone Relaxin Prostaglandin I2 Nitric oxide PTH-RP This phase normally comprises 95 percent of pregnancy and is characterized by uterine smooth muscle tranquility with maintenance of cervical structural integrity. Some low-intensity myometrial contractions are felt during the quiescent phase, but they do not normally cause cervical dilatation. Contractions of this type become more common toward the end of pregnancy, especially in multiparous women, and are referred to as Braxton
  • 4. PHASE 2 parturition cascade The activation phase begins about 68 weeks before term and ends with the onset of regular uterine contractions. Changes in the myometrium and cervix that are essential to this phase are regulated by the fetal hypothalamo pituitaryadrenal axis, maternal hypothalamopituitaryaxis, and placental endocrine/paracrine factors. lead to increased uterine irritability and responsiveness to uterotonins agents that stimulate contractions. formation of the lower uterine segment from the isthmus - the fetal head often descends to or even through the pelvic inletso-called lightening.
  • 5. FEATURES AND MEDIATORS Changes in the myometrium Increase in contractility Increase in uterine responsiveness Increase in gap junctions Changes in the cervix - Cervical ripening Changes in collagen structure Increase in collagen solubility Infiltration by inflammatory cells Estrogen Progesterone CAPs OXY Rreceptors,pg F rep, connexin 43 [ gap jn pro] Glycosaminogly-cans Proteoglycans pCRH Prostaglandins Cortisol Interleukin-8 MMP
  • 6. Cervical ripening The cervix must undergo more extensive remodeling - eventually leading to cervical yielding and dilatation upon initiation of forceful uterine contractions principally involve connective tissue changes proteoglycans, glycosaminoglycans -cervical ripening. Many of the processes that aid cervical remodeling are controlled by the same hormones regulating uterine function The uterine corpus is predominantly smooth muscle, whereas the cervix is primarily connective tissue. Cellular components of the cervix include fibroblasts, epithelia, and few smooth muscle cells.
  • 7. Fetus in cascade activation of the fetal hypothalamic pituitaryadrenal axis Fetal CRH ACTH DHEAS 17 OH DHEAS BY FETAL LIVER-- ESTRIOL BY PLACENTA- PGF2 .= OXY REC, PG REC, GAP JN, FETAL ADRENAL-FETAL CORTISOL PG , OXY BY PLA . ANENCEPALY FETAL ADRENAL HYPOPLASIA
  • 8. PLACENTAL ROLE The placenta actively participates in the process of labor through the production of estrogens, progesterone, placental corticotropin releasing hormone and other substances PLACENTAL SULFATASE DEFICIENCY X LINKED DIS prevents conversion of sulphated estrogen precursors. Estrogens Alter estrogen: Progesterone receptor ratio Stimulate production of CAPs by placenta Cause uterine contraction Progesterone Causes uterine quiescence ANTIINFLAMMATORY EFF ON MYOMETRIUM Undergoes functional withdrawal at term Placental corticotropin-releasing hormone (pCRH) FETAL CORTISOL- Pcrh- ACTH and DHEAS- PG, OXYTOCIN
  • 9. MOTHER ROLE OXYTOCIN FETAL PIT, PLACENTA NO RISE AS SUCH Oxy receptors inc (100 -200) , inc in myometrial sensitivity to oxy Pg in decidua and membranes PG Fetal membranes and decidua contain phos-pholipase and cyclooxygenase enzymes. They are activated by local inflammatory reaction, trauma,stretch, estrogens, and progesterone. The increase in oxytocin and PG receptors in the myometrium plays a key role in uterine contractions. calcium influx to hormonal stimuli is the most important event in the initiation of contractions. Myometrial contraction during the parturition cascade is through actin and myosin interaction and interaction between myometrial cells via gap junctions.
  • 10. Phase 3 stimulation phase- labor I STAGE - stage of cervical effacement and dilatation. extrusion of the mucus plug that had previously filled the cervical canal during pregnancy is referred to as show or bloody show. Mechanical stretching of cx uterine activity ferguson reflex the upper segment contracts, retracts, and expels the fetus PAINFUL SMOOTH MSL CONTRACTION: 1) hypoxia of the contracted myometriumsuch as that with angina pectoris; (2) compression of nerve ganglia in the cervix and lower uterus by contracted interlocking muscle bundles; (3) cervical stretching during dilatation; and (4) stretching of the peritoneum overlying the fundus.
  • 11. The passive lower uterine segment is derived from the isthmus, and the physiological retraction ring develops at the junction of the upper and lower uterine segments. As a result of the lower segment thinning and concomitant upper segment thickening, a boundary between the two is marked by a ridge on the inner uterine surfacethe physiological retraction ring. When the thinning of the lower uterine segment is extreme, as in obstructed labor, the ring is prominent and forms a
  • 12. Cervical effacement obliteration or taking up of the cervix. I it is manifest clinically by shortening of the cervical canal from a length of approximately 2 cm to a mere circular orifice with almost paper-thin edges. The muscular fibers at the level of the internal cervical os are pulled upward, or taken up, into the lower uterine segment.
  • 14. III STAGE This sudden diminution in uterine size is inevitably accompanied by a decrease in the area of the placental implantation site For the placenta to accommodate itself to this reduced area, it increases in thickness, but because of limited placental elasticity, it is forced to buckle. The resulting tension pulls the weakest layerdecidua spongiosafrom that site.
  • 15. Phase 4 involution phase Features Involution of uterus and cervix Responsiveness of endometrium to ovarian hormones Mediators : Oxytocin Local factors Phase 4 or involution phase is known as the puerperium. The uterus and cervix return to the prepregnant state during this phase.