SI is supplemental instruction led by Caleb Peacock to help develop study skills. Variables are used to store and reference values in code. There are different data types like integers, floats, and strings. Variables must start with a letter or underscore and can include numbers and underscores but no spaces. Constant variables store fixed values in all caps. Comments describe code and are preceded by #. Basic math operations and mixing data types were demonstrated. The input function prompts users for input values stored in variables.