The document describes InSphero's easyEST system, which aims to make the Embryonic Stem Cell Test (EST) more efficient and automation-compatible. The EST requires producing mouse embryoid bodies through a manual and labor-intensive hanging drop method. InSphero's easyEST allows forming hanging drops in a 96-well plate through top loading, eliminating the need to manually turn dishes. Formed embryoid bodies can also be directly transferred to other plates without manual picking. This makes the EST process faster, easier, reproducible, and compatible with automation equipment.