The Renin-Angiotensin-Aldosterone System (RAAS) is a hormone system that regulates blood pressure and fluid balance. It is comprised of three main hormones: renin, angiotensin II, and aldosterone. The RAAS is primarily regulated by the rate of renal blood flow. It promotes oxidative stress in the brain, activating the RAAS and increasing sympathetic output, which can lead to hypertension when angiotensin II and aldosterone from the periphery act on the brain.
2. RAAS
Renin-Angiotensin-Aldosterone System
The Renin-Angiotensin-Aldosterone System
(RAAS) is a hormone system within the body that
is essential for the regulation of blood pressure
and fluid balance. The system is mainly
comprised of the three hormones renin,
angiotensin II and aldosterone. Primarily it is
regulated by the rate of renal blood flow.
6. The RAAS promotes oxidative
stress in the brain, further
activating the RAAS and
augmenting sympathetic outflow.
Angiotensin II and aldosterone of
peripheral origin act in the brain
to activate this cascade,
increasing sympathetic outflow
and leading to hypertension.
RAAS(Renin-Angiotensin-Aldosterone System)
How does RAAS work in hypertension?