RIN 4 (RPM1 Interacting Protein)
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RIN4 is a small A. thaliana protein localized to the plasma membrane that acts as a negative regulator of plant immunity responses. It interacts with the resistance proteins RPM1 and RPS2 and is targeted by several Pseudomonas syringae effectors like AvrB, AvrRpm1, and AvrRpt2. Current models suggest RIN4 may serve as a decoy to mimic the unknown real targets of these effectors and compete for binding, activating RPM1/RPS2-mediated immunity when effectors modify RIN4. RIN4 also regulates stomatal closure during infection and the evolution of this RIN4-mediated effector-triggered susceptibility system.
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APM event hosted by the South Wales and West of England Network (SWWE Network)
Speaker: Aalok Sonawala
The SWWE Regional Network were very pleased to welcome Aalok Sonawala, Head of PMO, National Programmes, Rider Levett Bucknall on 26 February, to BAWA for our first face to face event of 2025. Aalok is a member of APMs Thames Valley Regional Network and also speaks to members of APMs PMO Interest Network, which aims to facilitate collaboration and learning, offer unbiased advice and guidance.
Tonight, Aalok planned to discuss the importance of a PMO within project-based organisations, the different types of PMO and their key elements, PMO governance and centres of excellence.
PMOs within an organisation can be centralised, hub and spoke with a central PMO with satellite PMOs globally, or embedded within projects. The appropriate structure will be determined by the specific business needs of the organisation. The PMO sits above PM delivery and the supply chain delivery teams.
For further information about the event please click here.How to Configure Flexible Working Schedule in Odoo 18 Employee
How to Configure Flexible Working Schedule in Odoo 18 EmployeeCeline George
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In this slide, well discuss on how to configure flexible working schedule in Odoo 18 Employee module. In Odoo 18, the Employee module offers powerful tools to configure and manage flexible working schedules tailored to your organization's needs.APM People Interest Network Conference - Tim Lyons - The neurological levels ...
APM People Interest Network Conference - Tim Lyons - The neurological levels ...Association for Project Management
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APM People Interest Network Conference 2025
-Autonomy, Teams and Tension: Projects under stress
-Tim Lyons
-The neurological levels of
team-working: Harmony and tensions
With a background in projects spanning more than 40 years, Tim Lyons specialised in the delivery of large, complex, multi-disciplinary programmes for clients including Crossrail, Network Rail, ExxonMobil, Siemens and in patent development. His first career was in broadcasting, where he designed and built commercial radio station studios in Manchester, Cardiff and Bristol, also working as a presenter and programme producer. Tim now writes and presents extensively on matters relating to the human and neurological aspects of projects, including communication, ethics and coaching. He holds a Masters degree in NLP, is an NLP Master Practitioner and International Coach. He is the Deputy Lead for APMs People Interest Network.
Session | The Neurological Levels of Team-working: Harmony and Tensions
Understanding how teams really work at conscious and unconscious levels is critical to a harmonious workplace. This session uncovers what those levels are, how to use them to detect and avoid tensions and how to smooth the management of change by checking you have considered all of them.Blind Spots in AI and Formulation Science Knowledge Pyramid (Updated Perspect...
Blind Spots in AI and Formulation Science Knowledge Pyramid (Updated Perspect...Ajaz Hussain
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This presentation delves into the systemic blind spots within pharmaceutical science and regulatory systems, emphasizing the significance of "inactive ingredients" and their influence on therapeutic equivalence. These blind spots, indicative of normalized systemic failures, go beyond mere chance occurrences and are ingrained deeply enough to compromise decision-making processes and erode trust.
Historical instances like the 1938 FD&C Act and the Generic Drug Scandals underscore how crisis-triggered reforms often fail to address the fundamental issues, perpetuating inefficiencies and hazards.
The narrative advocates a shift from reactive crisis management to proactive, adaptable systems prioritizing continuous enhancement. Key hurdles involve challenging outdated assumptions regarding bioavailability, inadequately funded research ventures, and the impact of vague language in regulatory frameworks.
The rise of large language models (LLMs) presents promising solutions, albeit with accompanying risks necessitating thorough validation and seamless integration.
Tackling these blind spots demands a holistic approach, embracing adaptive learning and a steadfast commitment to self-improvement. By nurturing curiosity, refining regulatory terminology, and judiciously harnessing new technologies, the pharmaceutical sector can progress towards better public health service delivery and ensure the safety, efficacy, and real-world impact of drug products.How to Setup WhatsApp in Odoo 17 - Odoo 際際滷s
How to Setup WhatsApp in Odoo 17 - Odoo 際際滷sCeline George
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Integrate WhatsApp into Odoo using the WhatsApp Business API or third-party modules to enhance communication. This integration enables automated messaging and customer interaction management within Odoo 17.Lesson Plan M1 2024 Lesson Plan M1 2024 Lesson Plan M1 2024 Lesson Plan M1...
Lesson Plan M1 2024 Lesson Plan M1 2024 Lesson Plan M1 2024 Lesson Plan M1...pinkdvil200
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Lesson Plan M1 2024 Lesson Plan M1 2024 Lesson Plan M1 2024 Eng7-Q4-Lesson 1 Part 1 Understanding Discipline-Specific Words, Voice, and T...
Eng7-Q4-Lesson 1 Part 1 Understanding Discipline-Specific Words, Voice, and T...sandynavergas1
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Understanding Discipline-Specific Words, Voice, and Technical Terms
APM People Interest Network Conference - Oliver Randall & David Bovis - Own Y...
APM People Interest Network Conference - Oliver Randall & David Bovis - Own Y...Association for Project Management
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APM People Interest Network Conference 2025
- Autonomy, Teams and Tension
- Oliver Randall & David Bovis
- Own Your Autonomy
Oliver Randall
Consultant, Tribe365
Oliver is a career project professional since 2011 and started volunteering with APM in 2016 and has since chaired the People Interest Network and the North East Regional Network. Oliver has been consulting in culture, leadership and behaviours since 2019 and co-developed HPTM速an off the shelf high performance framework for teams and organisations and is currently working with SAS (Stellenbosch Academy for Sport) developing the culture, leadership and behaviours framework for future elite sportspeople whilst also holding down work as a project manager in the NHS at North Tees and Hartlepool Foundation Trust.
David Bovis
Consultant, Duxinaroe
A Leadership and Culture Change expert, David is the originator of BTFA and The Dux Model.
With a Masters in Applied Neuroscience from the Institute of Organisational Neuroscience, he is widely regarded as the Go-To expert in the field, recognised as an inspiring keynote speaker and change strategist.
He has an industrial engineering background, majoring in TPS / Lean. David worked his way up from his apprenticeship to earn his seat at the C-suite table. His career spans several industries, including Automotive, Aerospace, Defence, Space, Heavy Industries and Elec-Mech / polymer contract manufacture.
Published in Londons Evening Standard quarterly business supplement, James Caans Your business Magazine, Quality World, the Lean Management Journal and Cambridge Universities PMA, he works as comfortably with leaders from FTSE and Fortune 100 companies as he does owner-managers in SMEs. He is passionate about helping leaders understand the neurological root cause of a high-performance culture and sustainable change, in business.
Session | Own Your Autonomy The Importance of Autonomy in Project Management
#OwnYourAutonomy is aiming to be a global APM initiative to position everyone to take a more conscious role in their decision making process leading to increased outcomes for everyone and contribute to a world in which all projects succeed.
We want everyone to join the journey.
#OwnYourAutonomy is the culmination of 3 years of collaborative exploration within the Leadership Focus Group which is part of the APM People Interest Network. The work has been pulled together using the 5 HPTM速 Systems and the BTFA neuroscience leadership programme.
https://www.linkedin.com/showcase/apm-people-network/about/Kaun TALHA quiz Finals -- El Dorado 2025
Kaun TALHA quiz Finals -- El Dorado 2025Conquiztadors- the Quiz Society of Sri Venkateswara College
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APM People Interest Network Conference - Tim Lyons - The neurological levels ...
APM People Interest Network Conference - Tim Lyons - The neurological levels ...Association for Project Management
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APM People Interest Network Conference - Oliver Randall & David Bovis - Own Y...
APM People Interest Network Conference - Oliver Randall & David Bovis - Own Y...Association for Project Management
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RIN 4 (RPM1 Interacting Protein)
- 1. RIN 4 (RPM1 Interacting Protein) By, Bharati Singh
- 2. RIN 4 (RPM1 Interacting Protein) A small, A. thaliana protein, that along with RPM1 and RPS2 is localized to the plasma membrane Effectors from P. syringae HopF2 RIN4 AvrB AvrRPM1 AvrRpt2 Negative regulator of PTI (PAMP Triggered Immunity) and ETI (Effector Triggered Immunity)
- 3. To solve major problem in plant immunity ,Guard Hypothesis was put forward H. Spoel et al. (2012) Nature Review
- 4. RIN4 regulates stomata during infection Model of PAMP induced stomatal closure Jun Liu et al.(2009), Max Planck Institute, Germany
- 5. Decoy model Current opinion tends to believe that RIN4 serves as a decoy to mimic the unknown real target of RIN4 interacted effectors to compete for binding with these effectors
- 6. Evolution of RIN4-RPM1/RPS2 mediated ETI Mutant Type Wild Type Decoy ETS Hou et al. (2011), plant signaling & Behaviour