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The document discusses various topics including:
- Hercule Poirot's reliance on his "little grey cells" for solving cases
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This document discusses pancreatic cancer and its treatment. It begins by stating that pancreatic cancer is most commonly diagnosed as locally advanced or metastatic. It then discusses the role of surgery, chemotherapy, and radiation therapy in the treatment of pancreatic cancer. It notes that the majority of surgically treated patients will have a recurrence, with a median survival of 15-20 months. The value of adjuvant and neoadjuvant therapy is debated. The document summarizes several clinical trials investigating chemotherapy and chemoradiation as adjuvant treatment after surgery. It also discusses neoadjuvant therapy and its potential advantages over adjuvant therapy. Emerging strategies discussed include induction chemotherapy followed by localized chemoradiation or second line therapy. The document concludes by describing modern radiationradiotherapy of bone metastases,Vakalis
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This document provides information on the evaluation and treatment of metastatic bone disease and spinal cord compression. It discusses:
1. Common sites of bone metastases from various primary cancers. Imaging tools to evaluate bone metastases like x-rays, bone scans, CT, PET, and MRI scans are described.
2. A multi-disciplinary treatment approach is recommended, including medical treatment, surgery, radiotherapy, radionuclides, chemotherapy, and hormonal therapy.
3. Details are provided on conventional and advanced radiation therapy techniques for treating bone metastases and spinal cord compression, including stereotactic radiosurgery. Overall pain relief rates, time to pain relief, and the benefits of combining surgery and radiation therapy aresbrt for inoperable lung cancer
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This document discusses stereotactic body radiotherapy (SBRT) for early stage lung cancer patients who cannot undergo surgery. It describes how SBRT delivers a high radiation dose to the tumor in just 1-5 sessions. Studies show SBRT provides improved tumor control compared to conventional radiotherapy, with surprisingly low toxicity. Early investigations found 3-year tumor control rates of 60-80% with SBRT, similar to surgery. Larger prospective trials of SBRT for medically inoperable early stage lung cancer patients demonstrated 3-year local control of 90-98% and low risks of side effects. SBRT provides an effective non-invasive alternative to surgery for these high-risk patients.Spinal cord compression bhf aos study day mar 2014 final
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The document discusses breast cancer treatment recommendations including:
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This document discusses recent data on radiation therapy for prostate cancer. It begins by outlining the risk of prostate cancer development and mortality rates over time. It then examines risk stratification systems and treatment options for low, intermediate, and high risk disease. The document focuses on the benefits of dose escalation in radiation therapy, noting several studies that found higher radiation doses improved outcomes with acceptable toxicity when using newer techniques like IMRT. It also discusses hypofractionated regimens and image-guided radiation as ways to further improve the therapeutic ratio. In summary, this document reviews evidence that higher and more precisely delivered radiation doses can improve prostate cancer control while maintaining reasonable side effects.
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This document summarizes a presentation on new perspectives on second-line therapy for non-small cell lung cancer (NSCLC). The presentation discusses current standards of care for second-line NSCLC, the unique needs of patients without targetable mutations, and emerging research findings. One study presented was the LUME-Lung 1 trial which found that the addition of the angiogenesis inhibitor nintedanib to docetaxel improved progression-free survival compared to placebo plus docetaxel in second-line NSCLC, with a significant overall survival benefit seen in the adenocarcinoma subgroup. Outstanding issues regarding biomarkers and the role of nintedanib in squamous cell carcinoma were discussed.
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The document discusses the radiobiology behind dose fractionation in radiation therapy. It provides an overview of the linear quadratic model which describes how cell survival changes with dose and is used to determine biologically equivalent doses for different fractionation schedules. The model assumes equal effect per fraction but may not be accurate at high or low doses. Fractionation takes advantage of the four R's - repair, repopulation, redistribution, and reoxygenation - to better kill tumors while sparing normal tissues. The alpha/beta ratio indicates a tissue's sensitivity to fractionation and is used to estimate equivalent total doses for different fraction sizes.2012-michael joiner-hypofractionation
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The document discusses how tumor radiobiology may impact the move toward hypofractionation in radiation therapy. It reviews evidence that the classic linear-quadratic model does not fully capture tumor response at high radiation doses, and that other factors like vascular damage and immune effects become more important. Response heterogeneity between different tumor cell populations may also help explain why survival curves appear more linear at higher doses per fraction.RECTAL CA - VAKALIS . X
RECTAL CA - VAKALIS . Xfondas vakalis
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Rectal cancer treatment typically involves surgery. Local recurrence after conventional surgery occurs in 15-65% of cases on average. Long course preoperative chemoradiotherapy has been shown to reduce local recurrence rates compared to short course preoperative radiotherapy or radiotherapy alone. It increases local tumor control and survival rates with some toxicities but does not reduce colostomy rates. Preoperative chemoradiotherapy is superior to postoperative chemoradiotherapy in reducing local recurrence rates without affecting overall survival.
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一比一原版(颁叠鲍毕业证)卡普顿大学毕业证如何办理
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