Sepsis is a serious condition that can lead to death if not properly recognized and treated quickly. The UK Sepsis Trust works to increase awareness of sepsis and improve sepsis care and outcomes in the UK. While progress has been made in some areas, compliance with best practices like administering antibiotics within an hour remains low. The Trust advocates for standardized protocols, improved communication between primary and secondary care, source control, and ensuring antimicrobial expertise is available 24/7 to help tackle sepsis.
New diagnostic tools in sepsis - Adam Linder - SSAI2017scanFOAM
油
A talk by Adam Linder at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Content delivered in collaboration between scanFOAM, SSAI & SFAI.
dr Franciscus Ginting - Sepsis PIN PAPDI Surabaya WS-051019.pdfcorinafiqliyin
油
Penegakan diagnosis sepsis sangat diperlukan dalam kasus sepsis itu sendiri. Sepsis dapat disebabkan oleh beberapa hal. Salah satu komplikasi yang dapat timbul adalah syok sepis
Dr. Anna Garner presented on updates in HIV and STIs. Key points included:
1) Late HIV diagnosis remains an issue in the UK, with many patients presenting only after developing AIDS-related illnesses. Missed opportunities for earlier testing contribute to late diagnoses.
2) STIs such as LGV have seen resurgences in certain populations. Ocular syphilis can also present an atypical symptom of syphilis infection.
3) Increased HIV and STI testing is needed in high prevalence areas. All healthcare providers should consider HIV in their differential and offer testing when appropriate to diagnose more patients earlier.
Sepsis & Hospice Eligibility: Natural History, Prognosis & Role of HospiceVITAS Healthcare
油
Sepsis can lead to organ dysfunction and death in the hospital setting. Approximately 25-50% of hospital deaths are sepsis-related. Some sepsis patients who do not die in the hospital still have a poor prognosis and increased mortality risk. Up to 40% of sepsis patients meet hospice eligibility guidelines at the time of hospital admission based on their underlying illness and sepsis complications. After hospitalization, sepsis survivors are at risk for post-sepsis syndrome which can include new physical and cognitive limitations that affect quality of life and functional status.
KMC HIV/AIDS Messages By DR Munawar Khan DDO(Curative) EDO Health KarachiDr Munawar Khan
油
The document discusses HIV/AIDS in Pakistan. It outlines several key objectives: creating awareness of the seriousness of the disease; ensuring people are equipped with knowledge to protect themselves; and reducing transmission through blood and blood products. It then provides details on infrastructure and services in place, including testing and treatment centers. It discusses the history and origins of HIV, current statistics on global and national prevalence, and risk factors. Finally, it covers transmission methods, vulnerable groups, symptoms, testing options, myths and challenges. The overall aim is to educate about HIV/AIDS prevention and management in Pakistan.
This document provides information about a syphilis outbreak in Wake County, North Carolina. Syphilis case numbers are at a 15-year high in Wake County, with 245 cases reported in 2015. The outbreak is affecting primarily men who have sex with men (MSM), with 92% of 2015 cases occurring among men. Public health officials are working to identify and treat infected individuals, prevent further transmission, and help stop the outbreak. Physicians are required by law to report syphilis and other sexually transmitted disease cases to county and state health departments.
Presentations from the 1st May 2018 event Gram-negative Bloodstream infections: ensuring board assurance against national standards. Hosted by NHS Improvement and NHS England
1) The author's father died of sepsis after being taken to the ER for what seemed like heart failure. The author was unaware of sepsis prior to this.
2) Sepsis is a deadly condition caused by an overactive immune response to infection that can result in organ failure and death. It is difficult to diagnose due to vague symptoms.
3) Most sepsis cases start outside the hospital, but it is often not detected or treated quickly enough, increasing the risk of death. Earlier and more accurate diagnosis is needed to improve outcomes.
The definition of sepsis continues to change for both patients and healthcare providers. Medicine does not currently share a consensus understanding of sepsis which may place patients at greater risk.
This presentation goes beyond the controversy of Sepsis-3 and provides a Data Science solution to the 3,000-year-old problem known as sepsis.
The document summarizes guidelines for diagnosing and managing sepsis published in 2016. It defines sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, and septic shock as sepsis with circulatory, cellular, and metabolic dysfunction associated with higher mortality. Pneumonia is the most common cause of sepsis. Initial evaluation includes basic tests, cultures, imaging, and biomarkers like procalcitonin and lactate. Fluid resuscitation and antibiotics should begin within three hours, with vasopressors as needed for hypotension.
The future of the emergency room | Jean-Louis Vincent at TBS23scanFOAM
油
This document discusses the future of emergency medicine and intensive care. It suggests that emergency departments will see both smaller and larger patient populations as telemedicine and home care become more prevalent, allowing efficient comprehensive management. Specialists, labs, imaging, and AI will play larger roles. Triage and disposition may be aided by AI, and the roles of ER, ICU, and specialists will evolve in an integrated hospital network supported by telemedicine. Data standardization, large databases, and AI/machine learning can help provide personalized care and evaluate new therapies.
This document discusses sepsis and septic shock, including definitions, diagnosis, pathophysiology, and clinical decision making. It notes that sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Screening tools like SIRS criteria and qSOFA score can help identify sepsis, though they have limitations. Management relies on early antibiotics, fluid resuscitation, and hemodynamic support with vasopressors as needed. Mortality from septic shock remains high, around 35-40%, despite best efforts.
The document discusses early treatment for sepsis patients. It summarizes that early and appropriate antimicrobial therapy is key to reducing mortality from sepsis. It then discusses definitions of sepsis that have evolved over time from 1991 to 2016. The Sequential Organ Failure Assessment (SOFA) score and quick SOFA (qSOFA) score are introduced to better predict mortality risk and identify organ dysfunction in sepsis patients compared to the previous systemic inflammatory response syndrome (SIRS) criteria. The SOFA score is shown to have superior predictive validity for in-hospital mortality compared to SIRS criteria or qSOFA score.
This downloadable slideset summarizes optimal evidence-based antiretroviral therapy management strategies for a series of challenging clinical cases and is based on a satellite symposium presented at HIV Glasgow 2016.
Format: Microsoft PowerPoint (.ppt)
File size: 1.32 MB
Date posted: 11/11/2016
This document provides an overview of Catherine T. Yu's background and credentials. It then summarizes her presentation on infectious hazards and occupational exposures for healthcare workers. The key points discussed include:
- Common infectious agents that pose risks to healthcare workers through blood or bodily fluid exposure
- Groups of healthcare workers at highest risk of acquiring bloodborne pathogens
- Modes of transmission for bloodborne pathogens like HIV, HBV, and HCV
- Post-exposure management protocols for exposures, including recommended prophylaxis and follow-up testing
The future of the emergency room | Jean-Louis Vincent at TBS23scanFOAM
油
This document discusses the future of emergency medicine and intensive care. It predicts that emergency departments will see:
- Smaller patient populations treated through telemedicine and home care with more efficient comprehensive management.
- Larger patient populations as specialist physicians, labs, imaging and AI are integrated into emergency care.
Triage will sort patients by urgency to minimize wait times. AI will increasingly assist with diagnosis, treatment recommendations and remote consultations. Intensive care will see more remote monitoring, personalized treatment guided by AI, and data-driven therapies evaluated through large databases. However, challenges remain around data standardization, implementation costs, and ensuring AI recommendations are tailored to individual patients.
The document discusses health issues and response strategies during the 2008 Kosi floods in India. It outlines principles of epidemiology and surveillance tools to detect outbreaks. It describes anticipated health problems like diarrhea, respiratory infections, and vector-borne diseases. Metrics for monitoring mortality, morbidity and outbreaks are provided. The response should include vaccination campaigns, treatment of illness, prevention of water-borne and vector-borne diseases through water purification, sanitation and hygiene measures.
Sepsis & Hospice Eligibility: Natural History, Prognosis & Role of HospiceVITAS Healthcare
油
The goal of this webinar is to educate healthcare clinicians about the history, incidence, impact and identification of sepsis in the acute-care setting. Hospice care is inadequately utilized for patients with sepsis, a serious condition that results in 250,000 US deaths each year and an annual $3.5 billion in hospital readmission costs.
Cardiff University Healthy Ageing Conference & Public Lecture
The importance of a healthy lifestyle
A Conference and a Public Lecture
Thursday 30th October 2014
http://medicine.cardiff.ac.uk/event/healthy-ageing-conference-public-lecture/
Prevention and early detection of Prostate Cancer: a global view Vitaly Smelov, International Agency for Research on Cancer (IARC), World Health Organisation (WHO)
This document outlines objectives and content for a presentation on implementing protocols for early recognition and management of maternal sepsis. The objectives include identifying differences between sepsis, severe sepsis, and septic shock; symptoms for early recognition and management; and the importance of implementing OB sepsis screening, protocols, training staff, and collecting data. Causes of maternal sepsis are discussed. Screening criteria are adjusted for perinatal patients compared to non-OB adults. Definitions of sepsis, severe sepsis, septic shock, and bundles are provided. Delays in diagnosis and treatment are linked to increased mortality, so early recognition and treatment through bundles are important for improving outcomes in maternal sepsis.
The document summarizes successes and challenges in rolling out antiretroviral therapy (ART) in low-income countries. Key successes include increasing ART access through lowered drug prices and expanded treatment guidelines by the WHO. However, challenges remain such as late treatment initiation leading to high mortality, low pediatric diagnosis rates, limited second-line treatment options, and loss to follow up. Ongoing efforts are needed to further scale up and improve ART programs.
Title: Regulation of Tubular Reabsorption A Comprehensive Overview
Description:
This lecture provides a detailed and structured explanation of the mechanisms regulating tubular reabsorption in the kidneys. It explores how different physiological and hormonal factors influence glomerular filtration and reabsorption rates, ensuring fluid and electrolyte balance in the body.
Who Should Read This?
This presentation is designed for:
鏝 Medical Students (MBBS, BDS, Nursing, Allied Health Sciences) preparing for physiology exams.
鏝 Medical Educators & Professors looking for structured teaching material.
鏝 Healthcare Professionals (doctors, nephrologists, and physiologists) seeking a refresher on renal physiology.
鏝 Postgraduate Students & Researchers in the field of medical sciences and physiology.
What Youll Learn:
Local Regulation of Tubular Reabsorption
鏝 Glomerulo-Tubular Balance its mechanism and clinical significance
鏝 Net reabsorptive forces affecting peritubular capillaries
鏝 Role of peritubular hydrostatic and colloid osmotic pressures
Hormonal Regulation of Tubular Reabsorption
鏝 Effects of Aldosterone, Angiotensin II, ADH, and Natriuretic Peptides
鏝 Clinical conditions like Addisons disease & Conn Syndrome
鏝 Mechanisms of pressure natriuresis and diuresis
Nervous System Regulation
鏝 Sympathetic Nervous System activation and its effects on sodium reabsorption
Clinical Correlations & Case Discussions
鏝 How renal regulation is altered in hypertension, hypotension, and proteinuria
鏝 Comparison of Glomerulo-Tubular Balance vs. Tubulo-Glomerular Feedback
This presentation provides detailed diagrams, flowcharts, and calculations to enhance understanding and retention. Whether you are studying, teaching, or practicing medicine, this lecture will serve as a valuable resource for mastering renal physiology.
Keywords for Easy Search:
#Physiology #RenalPhysiology #TubularReabsorption #GlomeruloTubularBalance #HormonalRegulation #MedicalEducation #Nephrology
PERSONALITY DEVELOPMENT & DEFENSE MECHANISMS.pptxPersonality and environment:...ABHAY INSTITUTION
油
Personality theory is a collection of ideas that explain how a person's personality develops and how it affects their behavior. It also seeks to understand how people react to situations, and how their personality impacts their relationships.
Key aspects of personality theory
Personality traits: The characteristics that make up a person's personality.
Personality development: How a person's personality develops over time.
Personality disorders: How personality theories can be used to study personality disorders.
Personality and environment: How a person's personality is influenced by their environment.
Presentations from the 1st May 2018 event Gram-negative Bloodstream infections: ensuring board assurance against national standards. Hosted by NHS Improvement and NHS England
1) The author's father died of sepsis after being taken to the ER for what seemed like heart failure. The author was unaware of sepsis prior to this.
2) Sepsis is a deadly condition caused by an overactive immune response to infection that can result in organ failure and death. It is difficult to diagnose due to vague symptoms.
3) Most sepsis cases start outside the hospital, but it is often not detected or treated quickly enough, increasing the risk of death. Earlier and more accurate diagnosis is needed to improve outcomes.
The definition of sepsis continues to change for both patients and healthcare providers. Medicine does not currently share a consensus understanding of sepsis which may place patients at greater risk.
This presentation goes beyond the controversy of Sepsis-3 and provides a Data Science solution to the 3,000-year-old problem known as sepsis.
The document summarizes guidelines for diagnosing and managing sepsis published in 2016. It defines sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, and septic shock as sepsis with circulatory, cellular, and metabolic dysfunction associated with higher mortality. Pneumonia is the most common cause of sepsis. Initial evaluation includes basic tests, cultures, imaging, and biomarkers like procalcitonin and lactate. Fluid resuscitation and antibiotics should begin within three hours, with vasopressors as needed for hypotension.
The future of the emergency room | Jean-Louis Vincent at TBS23scanFOAM
油
This document discusses the future of emergency medicine and intensive care. It suggests that emergency departments will see both smaller and larger patient populations as telemedicine and home care become more prevalent, allowing efficient comprehensive management. Specialists, labs, imaging, and AI will play larger roles. Triage and disposition may be aided by AI, and the roles of ER, ICU, and specialists will evolve in an integrated hospital network supported by telemedicine. Data standardization, large databases, and AI/machine learning can help provide personalized care and evaluate new therapies.
This document discusses sepsis and septic shock, including definitions, diagnosis, pathophysiology, and clinical decision making. It notes that sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Screening tools like SIRS criteria and qSOFA score can help identify sepsis, though they have limitations. Management relies on early antibiotics, fluid resuscitation, and hemodynamic support with vasopressors as needed. Mortality from septic shock remains high, around 35-40%, despite best efforts.
The document discusses early treatment for sepsis patients. It summarizes that early and appropriate antimicrobial therapy is key to reducing mortality from sepsis. It then discusses definitions of sepsis that have evolved over time from 1991 to 2016. The Sequential Organ Failure Assessment (SOFA) score and quick SOFA (qSOFA) score are introduced to better predict mortality risk and identify organ dysfunction in sepsis patients compared to the previous systemic inflammatory response syndrome (SIRS) criteria. The SOFA score is shown to have superior predictive validity for in-hospital mortality compared to SIRS criteria or qSOFA score.
This downloadable slideset summarizes optimal evidence-based antiretroviral therapy management strategies for a series of challenging clinical cases and is based on a satellite symposium presented at HIV Glasgow 2016.
Format: Microsoft PowerPoint (.ppt)
File size: 1.32 MB
Date posted: 11/11/2016
This document provides an overview of Catherine T. Yu's background and credentials. It then summarizes her presentation on infectious hazards and occupational exposures for healthcare workers. The key points discussed include:
- Common infectious agents that pose risks to healthcare workers through blood or bodily fluid exposure
- Groups of healthcare workers at highest risk of acquiring bloodborne pathogens
- Modes of transmission for bloodborne pathogens like HIV, HBV, and HCV
- Post-exposure management protocols for exposures, including recommended prophylaxis and follow-up testing
The future of the emergency room | Jean-Louis Vincent at TBS23scanFOAM
油
This document discusses the future of emergency medicine and intensive care. It predicts that emergency departments will see:
- Smaller patient populations treated through telemedicine and home care with more efficient comprehensive management.
- Larger patient populations as specialist physicians, labs, imaging and AI are integrated into emergency care.
Triage will sort patients by urgency to minimize wait times. AI will increasingly assist with diagnosis, treatment recommendations and remote consultations. Intensive care will see more remote monitoring, personalized treatment guided by AI, and data-driven therapies evaluated through large databases. However, challenges remain around data standardization, implementation costs, and ensuring AI recommendations are tailored to individual patients.
The document discusses health issues and response strategies during the 2008 Kosi floods in India. It outlines principles of epidemiology and surveillance tools to detect outbreaks. It describes anticipated health problems like diarrhea, respiratory infections, and vector-borne diseases. Metrics for monitoring mortality, morbidity and outbreaks are provided. The response should include vaccination campaigns, treatment of illness, prevention of water-borne and vector-borne diseases through water purification, sanitation and hygiene measures.
Sepsis & Hospice Eligibility: Natural History, Prognosis & Role of HospiceVITAS Healthcare
油
The goal of this webinar is to educate healthcare clinicians about the history, incidence, impact and identification of sepsis in the acute-care setting. Hospice care is inadequately utilized for patients with sepsis, a serious condition that results in 250,000 US deaths each year and an annual $3.5 billion in hospital readmission costs.
Cardiff University Healthy Ageing Conference & Public Lecture
The importance of a healthy lifestyle
A Conference and a Public Lecture
Thursday 30th October 2014
http://medicine.cardiff.ac.uk/event/healthy-ageing-conference-public-lecture/
Prevention and early detection of Prostate Cancer: a global view Vitaly Smelov, International Agency for Research on Cancer (IARC), World Health Organisation (WHO)
This document outlines objectives and content for a presentation on implementing protocols for early recognition and management of maternal sepsis. The objectives include identifying differences between sepsis, severe sepsis, and septic shock; symptoms for early recognition and management; and the importance of implementing OB sepsis screening, protocols, training staff, and collecting data. Causes of maternal sepsis are discussed. Screening criteria are adjusted for perinatal patients compared to non-OB adults. Definitions of sepsis, severe sepsis, septic shock, and bundles are provided. Delays in diagnosis and treatment are linked to increased mortality, so early recognition and treatment through bundles are important for improving outcomes in maternal sepsis.
The document summarizes successes and challenges in rolling out antiretroviral therapy (ART) in low-income countries. Key successes include increasing ART access through lowered drug prices and expanded treatment guidelines by the WHO. However, challenges remain such as late treatment initiation leading to high mortality, low pediatric diagnosis rates, limited second-line treatment options, and loss to follow up. Ongoing efforts are needed to further scale up and improve ART programs.
Title: Regulation of Tubular Reabsorption A Comprehensive Overview
Description:
This lecture provides a detailed and structured explanation of the mechanisms regulating tubular reabsorption in the kidneys. It explores how different physiological and hormonal factors influence glomerular filtration and reabsorption rates, ensuring fluid and electrolyte balance in the body.
Who Should Read This?
This presentation is designed for:
鏝 Medical Students (MBBS, BDS, Nursing, Allied Health Sciences) preparing for physiology exams.
鏝 Medical Educators & Professors looking for structured teaching material.
鏝 Healthcare Professionals (doctors, nephrologists, and physiologists) seeking a refresher on renal physiology.
鏝 Postgraduate Students & Researchers in the field of medical sciences and physiology.
What Youll Learn:
Local Regulation of Tubular Reabsorption
鏝 Glomerulo-Tubular Balance its mechanism and clinical significance
鏝 Net reabsorptive forces affecting peritubular capillaries
鏝 Role of peritubular hydrostatic and colloid osmotic pressures
Hormonal Regulation of Tubular Reabsorption
鏝 Effects of Aldosterone, Angiotensin II, ADH, and Natriuretic Peptides
鏝 Clinical conditions like Addisons disease & Conn Syndrome
鏝 Mechanisms of pressure natriuresis and diuresis
Nervous System Regulation
鏝 Sympathetic Nervous System activation and its effects on sodium reabsorption
Clinical Correlations & Case Discussions
鏝 How renal regulation is altered in hypertension, hypotension, and proteinuria
鏝 Comparison of Glomerulo-Tubular Balance vs. Tubulo-Glomerular Feedback
This presentation provides detailed diagrams, flowcharts, and calculations to enhance understanding and retention. Whether you are studying, teaching, or practicing medicine, this lecture will serve as a valuable resource for mastering renal physiology.
Keywords for Easy Search:
#Physiology #RenalPhysiology #TubularReabsorption #GlomeruloTubularBalance #HormonalRegulation #MedicalEducation #Nephrology
PERSONALITY DEVELOPMENT & DEFENSE MECHANISMS.pptxPersonality and environment:...ABHAY INSTITUTION
油
Personality theory is a collection of ideas that explain how a person's personality develops and how it affects their behavior. It also seeks to understand how people react to situations, and how their personality impacts their relationships.
Key aspects of personality theory
Personality traits: The characteristics that make up a person's personality.
Personality development: How a person's personality develops over time.
Personality disorders: How personality theories can be used to study personality disorders.
Personality and environment: How a person's personality is influenced by their environment.
Presentaci坦 que va acompanyar la demostraci坦 prctica de metge d'Innovaci坦 Jos辿 Ferrer sobre el projecte Benestar de BSA, nom d'IDIAP Pere Gol, el 5 de mar巽 de 2025 a l'estand de XarSMART al Mobible Word Congress.
Rabies Bali 2008-2020_WRD Webinar_WSAVA 2020_Final.pptxWahid Husein
油
A decade of rabies control programmes in Bali with support from FAO ECTAD Indonesia with Mass Dog Vaccination, Integrated Bite Case Management, Dog Population Management, and Risk Communication as the backbone of the programmes
BIOMECHANICS OF THE MOVEMENT OF THE SHOULDER COMPLEX.pptxdrnidhimnd
油
The shoulder complex acts as in coordinated fashion to provide the smoothest and greatest range of motion possible of the upper limb.
Combined motion of GH and ST joint of shoulder complex helps in:
Distribution of motion between other two joints.
Maintenance of glenoid fossa in optimal position.
Maintenance of good length tension
Although some amount of glenohumeral motion may occur while the other shoulder articulations remain stabilized, movement of the humerus more commonly involves some movement at all three shoulder joints.
FAO's Support Rabies Control in Bali_Jul22.pptxWahid Husein
油
What is FAO doing to support rabies control programmes in Bali, Indonesia, using One Health approach with mass dog vaccination and integrated bite case management as main strategies
Dr. Anik Roy Chowdhury
MBBS, BCS(Health), DA, MD (Resident)
Department of Anesthesiology, ICU & Pain Medicine
Shaheed Suhrawardy Medical College Hospital (ShSMCH)
Solubilization in Pharmaceutical Sciences: Concepts, Mechanisms & Enhancement...KHUSHAL CHAVAN
油
This presentation provides an in-depth understanding of solubilization and its critical role in pharmaceutical formulations. It covers:
Definition & Mechanisms of Solubilization
Role of surfactants, micelles, and bile salts in drug solubility
Factors affecting solubilization (pH, polarity, particle size, temperature, etc.)
Methods to enhance drug solubility (Buffers, Co-solvents, Surfactants, Complexation, Solid Dispersions)
Advanced approaches (Polymorphism, Salt Formation, Co-crystallization, Prodrugs)
This resource is valuable for pharmaceutical scientists, formulation experts, regulatory professionals, and students interested in improving drug solubility and bioavailability.
Stability of Dosage Forms as per ICH GuidelinesKHUSHAL CHAVAN
油
This presentation covers the stability testing of pharmaceutical dosage forms according to ICH guidelines (Q1A-Q1F). It explains the definition of stability, various testing protocols, storage conditions, and evaluation criteria required for regulatory submissions. Key topics include stress testing, container closure systems, stability commitment, and photostability testing. The guidelines ensure that pharmaceutical products maintain their identity, purity, strength, and efficacy throughout their shelf life. This resource is valuable for pharmaceutical professionals, researchers, and regulatory experts.
Flag Screening in Physiotherapy Examination.pptxBALAJI SOMA
油
Flag screening is a crucial part of physiotherapy assessment that helps in identifying medical, psychological, occupational, and social barriers to recovery. Recognizing these flags ensures that physiotherapists make informed decisions, provide holistic care, and refer patients appropriately when necessary. By integrating flag screening into practice, physiotherapists can optimize patient outcomes and prevent chronicity of conditions.
This presentation provides a detailed exploration of the morphological and microscopic features of pneumonia, covering its histopathology, classification, and clinical significance. Designed for medical students, pathologists, and healthcare professionals, this lecture differentiates bacterial vs. viral pneumonia, explains lobar, bronchopneumonia, and interstitial pneumonia, and discusses diagnostic imaging patterns.
Key Topics Covered:
Normal lung histology vs. pneumonia-affected lung
Morphological changes in lobar, bronchopneumonia, and interstitial pneumonia
Microscopic features: Fibroblastic plugs, alveolar septal thickening, inflammatory cell infiltration
Stages of lobar pneumonia: Congestion, Red hepatization, Gray hepatization, Resolution
Common causative pathogens (Streptococcus pneumoniae, Klebsiella pneumoniae, Mycoplasma, etc.)
Clinical case study with diagnostic approach and differentials
Who Should Watch?
This is an essential resource for medical students, pathology trainees, and respiratory health professionals looking to enhance their understanding of pneumonias morphological aspects.
1. A Sepsis Quality Improvement project
Meeting the one-hour target
Diana Marujo
Senior Charge Nurse / Emergency Nurse Practitioner / Sepsis Lead
Emergency Department
Wexham Park Hospital
Oxford
2. Lay definition of sepsis: the Merinoff
definition:
Sepsis is a life-threatening
condition that arises when the
bodys response to an infection
injures its own tissues and organs.
Professional narrative definition of
Sepsis: Singer M et al (Sepsis-3):
Sepsis is characterised by a life-
threatening organ dysfunction due to
a dysregulated host response to
infection.
Definition of septic shock: Singer M et
al (Sepsis-3):
Septic shock is a subset of sepsis
where particularly profound circulatory,
cellular and metabolic abnormalities
substantially increase mortality.
Table 1: Sepsis incidence in England
(no. of episodes per year as reported by the Health and Social Care Information Centre (now NHS Digital)
Year 2010-11 2011-12 2012-13 2013-14 2014-15
Number 91,881 101,015 114,285 122,822 141,772
SEPSIS CLAIMS MORE LIVES
THAN LUNG CANCER, AND MORE
THAN BOWEL, BREAST AND
PROSTATE CANCER COMBINED
(46,000-67,000)
The Cost of Sepsis
YHEC estimated, given that there are at least
250,000 cases of sepsis every year, that sepsis
costs the NHS between 贈1.5 and 贈2 billion
each year, and our wider economy at least 贈11
billion and possibly as high as 贈15.6 billion.
The Sepsis Manual
Sepsis UK Trust
4th edition 2017 - 2018
250,000
year UK
4. WPH ED Sepsis Screening Tool
WPH ED Suspected Neutropenic Sepsis Tool
5. What was working?
Screening (after Patient First)
What needed to be improved?
Screening was poor (before PF)
Documentation using Sepsis
Screening Tool
Sepsis not identified
Sepsis identified but not escalated
Sepsis escalated but not treated
within 60 minutes
6. Sepsis Lead
Handovers / Board rounds
ED Sepsis Newsletter
Sepsis Champions
ED Sepsis Study Day
Sepsis Bleep Team
7. Emergency Department
Wexham Park Hospital
Sepsis Bleep Team Pathway 2019
Sepsis Team:
HCA: IV access + bloods
Nurse: Sepsis Screening
Tool + Antibiotics
Doctor: RAT
3666
4240
Hospital No. #
NEWS 5
Chemo 6/52
8. 0%
20%
40%
60%
80%
100%
Apr-19 May-19 Jun-19 Jul-19 Aug-19 Sep-19
% Sepsis Screening
ED CQUIN
0%
20%
40%
60%
80%
100%
Apr-19 May-19 Jun-19 Jul-19 Aug-19 Sep-19
% Antibiotics in 1 hour
ED CQUIN
June 2019:
From 57% in May to 82%
July 2019:
From 82% in June to 85%
August 2019:
From 85% in July to 90%
September 2019:
Maintaining 90%
Screening in the future:
Introduce pop-up window in
Symphony for chemo patients and
NEWS5
Create electronic Sepsis Screening Tool
9. 0
20
40
60
80
100
Jan-19 Feb-19 Mar-19 Apr-19 May-19 Jun-19 Jul-19
% FBC POC <45 min
0
20
40
60
80
100
Jan-19 Feb-19 Mar-19 Apr-19 May-19 Jun-19 Jul-19
% Antibiotics <60 min NS
From February to April 2019:
News programme Symphony
New Department EAC
What needed to be improved?
Walk-in patients
Between 30-40 patients a month
Only 13%-19% are neutropenic
11. The Sepsis Bleep Team is showing positive results.
More than 80% of the identified septic patients are now receiving antibiotics
within 60 minutes.
Also more than 80% of the suspected neutropenic patients are NOT
receiving unnecessary antibiotics.
Overall, by introducing the Sepsis Bleep Team deteriorating patients are
being prioritise, rapid assessment and treatment is being provided along
with good antibiotic stewardship.
12. Continue awareness
and training
Improve
documentation
Improve Screening and
Action Tool
Antibiotic stewardship
Work together with
multidisciplinary teams