The patient has clinical features consistent with myasthenia gravis including fatigable neck and leg muscles as well as symptoms affecting swallowing and voice. Repetitive nerve stimulation and SFEMG testing would help confirm the diagnosis. Positive voltage-gated calcium channel antibodies also support MG. The diagnosis is myasthenia gravis (option a).
- To detect neurogenic blocking on SFEMG, you need to record 3 spikes simultaneously.
- To detect neurogenic jitter on SFEMG, you need to record 4 spikes simultaneously. If only 3 spikes are recorded, the jitter may be due to triggering issues rather than a neurogenic cause.
- To ascertain that distal and proximal stimulation is of the exact same axon during conduction velocity testing, stimulate distally and proximally simultaneously. If the proximal response disappears with dual stimulation, it indicates collision and the same axon was stimulated.
The document contains questions and answers regarding neurophysiology techniques. Some key points discussed include:
- Voluntary activity does not influence CMAP amplitude at supramaximal stimulation, except for effects of muscle shortening.
- CMAP satellites can be distinguished from extra discharges by superimposing traces after 3Hz stimulation - satellites will be stable while extra discharges will be variable.
- If CMAP amplitude is unexpectedly low with no nerve damage or PNP, steps should be taken to check stimulation strength, equipment, skin conditions, and perform activation maneuvers before considering anomalies.
- F waves are usually normal in C8 radiculopathy but may be abnormal on the affected side in an ul
The document provides guidance on interpreting various neurography results. It discusses potential reasons for low amplitude compound muscle action potentials including carpal tunnel syndrome, lumbar epidural mass, technical problems, and polyneuropathy. It also discusses diagnoses for other neurography findings including possible carpal tunnel syndrome based on abnormal sensory findings in fingers 1-3 with normal motor amplitudes. Other sections discuss distinguishing between lumbar root lesions versus plexopathies and evaluating possible myasthenia gravis. The document aims to instruct on drawing conclusions from neurography studies.
A 21-year-old man presented with slowly progressive proximal muscle weakness and pain over 1 month. Neurography was normal. EMG showed myopathic motor unit potentials, interference patterns, and fibrillations. Ultrasound revealed hyperechogenicity and increased vascularization in the deltoid muscle. A muscle biopsy showed fiber diameter variation but no grouping. The likely diagnosis is polymyositis or dermatomyositis given the clinical presentation, normal neurography, myopathic EMG, and muscle biopsy findings.
This document discusses neuromuscular transmission testing, including repetitive nerve stimulation (RNS) protocols and analysis. It describes RNS protocols to evaluate myasthenia gravis and other neuromuscular disorders. Key points covered include RNS parameters to analyze like initial amplitude, decrement, and post-activation facilitation/exhaustion. It also discusses RNS considerations like muscle selection, temperature, and fixation effects. Normal RNS results and examples of abnormal findings in myasthenia gravis and congenital myasthenia are presented.
This document describes several classification systems for analyzing electromyography (EMG) results:
1. It classifies the degree of acute or subacute denervation seen on EMG as slight, moderate, or severe based on the duration of symptoms and EMG findings like fibrillation potentials and insertional activity.
2. It provides criteria for possible, probable, or definite myopathy based on spontaneous activity, motor unit potential morphology and instability, and involvement of muscle groups on EMG.
3. It outlines a quantitative EMG scoring system for evaluating myopathic changes with criteria in several categories.
4. It proposes a grading system for axonal and demyelinating peripheral neuropathy based
This document discusses different types of EMG electrodes used to measure jitter, including concentric needle electrodes and single fiber EMG electrodes. It presents data from studies measuring jitter with these electrodes in various muscles. Specifically, it shows jitter measurements are higher with concentric needle electrodes than single fiber electrodes in muscles from myasthenia gravis patients. The document also reviews the sensitivity of different diagnostic tests for myasthenia gravis, with jitter analysis and repetitive nerve stimulation having high sensitivity to detect the condition.
This document discusses various late responses and reflexes that can be measured using electrophysiological testing, including F-waves, A-waves, H-reflexes, and flexion reflexes. It provides information on the generator site, mechanism, and normal values for many of these late responses. Examples of abnormal late responses are shown in various neurological conditions like diabetic neuropathy, radiculopathy, amyotrophic lateral sclerosis, and myasthenia gravis. The document aims to characterize the typical electrophysiological features of late responses and reflexes.
This document discusses electromyography (EMG) techniques for evaluating myopathies. It describes how EMG can detect spontaneous muscle fiber activity like fibrillation potentials, myotonic discharges, and complex repetitive discharges that indicate a myopathy. It also discusses EMG analysis of motor unit potential amplitudes and frequencies, interference patterns, and muscle fiber characteristics like splitting that provide clues about normal and diseased muscle. While EMG is sensitive in detecting many myopathies, it is not always specific for differentiating between specific muscle disease subtypes. EMG combined with other clinical findings can help classify myopathies and distinguish myopathic from neuropathic processes.
The document discusses the use of telemedicine and networks in a neurophysiology laboratory. It describes:
1) How the lab uses networks and servers to share information, store patient data, and allow remote access to testing and reporting systems.
2) Examples of regional and international telemedicine collaborations, including video conferencing for consultations, remote supervision of testing, and quality assurance.
3) The future potential for telemedicine to develop national services, use smaller portable equipment, enable home monitoring, and facilitate international collaboration between individuals and research groups.
This document discusses macro electromyography (EMG), a technique used to study motor unit potentials (MUPs). Macro EMG involves inserting a cannula electrode into a muscle to record the electrical activity from many motor units at once, producing a macro motor unit potential (Macro MUP). The document also mentions multiunit triggered averaging, which averages Macro MUP signals to analyze individual motor unit characteristics from the combined signal.
This document discusses the development of single fiber electromyography (SFEMG) over time. Some key findings from SFEMG research include:
- SFEMG suggested that motor unit fibers are organized randomly rather than in subgroups, challenging previous theories.
- Propagation velocity along muscle fibers was measured, showing it decreases with activity and fatigue.
- The jitter phenomenon at the neuromuscular junction was identified as the source of variability in muscle fiber activation times.
- Technical developments like improved electrodes, filters, triggers and delay lines allowed more accurate measurement and understanding of single muscle fiber properties and motor unit organization.
SFEMG provided new insights into normal and diseased muscle physiology and remains
This document discusses testing for myasthenic disorders through repetitive nerve stimulation (RNS). It provides the RNS protocol of stimulating at 3Hz with 10 stimuli at rest, after 10 seconds of activity, and after 1 minute. Parameters like initial amplitude, decrement, and post-activity amplitude are analyzed. Several muscles are recommended for testing including deltoid, trapezius, and anconeus. Normal confidence limits for decrement in different muscles are provided. Examples of RNS results are shown for normal subjects, severe MG, LEMS, and congenital myasthenia. Potential pitfalls of RNS are also discussed.
1) The document provides guidelines for recording jitter with a concentric needle electrode (CNE), including definitions of acceptable CNE signals, techniques for voluntary and electrical stimulation activation, and potential errors in jitter measurements.
2) Examples are given of CNE recordings from different muscles that demonstrate normal voluntary activation, effects of varying stimulation frequency, axon reflex responses, and individual fiber blocking that is analyzed to determine jitter values.
3) Reference data from a multicenter study establishes normal mean jitter and maximum conduction delay (MCD) limits for different muscles based on CNE recordings.
1) Neurophysiological tests play an important role in diagnosing and monitoring motor neuron disease (MND) such as amyotrophic lateral sclerosis (ALS).
2) Electromyography (EMG) can detect lower motor neuron signs in both clinically affected and unaffected regions, helping to confirm diagnosis and exclude other conditions. It analyzes motor unit potential (MUP) parameters and presence of fibrillation potentials and fasciculation potentials.
3) Nerve conduction studies can exclude other neuropathies but often find only mild or no sensory involvement in ALS patients. Motor unit number estimation quantifies the loss of motor units over time in ALS.
The patient has clinical features consistent with myasthenia gravis including fatigable neck and leg muscles as well as symptoms affecting swallowing and voice. Repetitive nerve stimulation and SFEMG testing would help confirm the diagnosis. Positive voltage-gated calcium channel antibodies also support MG. The diagnosis is myasthenia gravis (option a).
- To detect neurogenic blocking on SFEMG, you need to record 3 spikes simultaneously.
- To detect neurogenic jitter on SFEMG, you need to record 4 spikes simultaneously. If only 3 spikes are recorded, the jitter may be due to triggering issues rather than a neurogenic cause.
- To ascertain that distal and proximal stimulation is of the exact same axon during conduction velocity testing, stimulate distally and proximally simultaneously. If the proximal response disappears with dual stimulation, it indicates collision and the same axon was stimulated.
The document contains questions and answers regarding neurophysiology techniques. Some key points discussed include:
- Voluntary activity does not influence CMAP amplitude at supramaximal stimulation, except for effects of muscle shortening.
- CMAP satellites can be distinguished from extra discharges by superimposing traces after 3Hz stimulation - satellites will be stable while extra discharges will be variable.
- If CMAP amplitude is unexpectedly low with no nerve damage or PNP, steps should be taken to check stimulation strength, equipment, skin conditions, and perform activation maneuvers before considering anomalies.
- F waves are usually normal in C8 radiculopathy but may be abnormal on the affected side in an ul
The document provides guidance on interpreting various neurography results. It discusses potential reasons for low amplitude compound muscle action potentials including carpal tunnel syndrome, lumbar epidural mass, technical problems, and polyneuropathy. It also discusses diagnoses for other neurography findings including possible carpal tunnel syndrome based on abnormal sensory findings in fingers 1-3 with normal motor amplitudes. Other sections discuss distinguishing between lumbar root lesions versus plexopathies and evaluating possible myasthenia gravis. The document aims to instruct on drawing conclusions from neurography studies.
A 21-year-old man presented with slowly progressive proximal muscle weakness and pain over 1 month. Neurography was normal. EMG showed myopathic motor unit potentials, interference patterns, and fibrillations. Ultrasound revealed hyperechogenicity and increased vascularization in the deltoid muscle. A muscle biopsy showed fiber diameter variation but no grouping. The likely diagnosis is polymyositis or dermatomyositis given the clinical presentation, normal neurography, myopathic EMG, and muscle biopsy findings.
This document discusses neuromuscular transmission testing, including repetitive nerve stimulation (RNS) protocols and analysis. It describes RNS protocols to evaluate myasthenia gravis and other neuromuscular disorders. Key points covered include RNS parameters to analyze like initial amplitude, decrement, and post-activation facilitation/exhaustion. It also discusses RNS considerations like muscle selection, temperature, and fixation effects. Normal RNS results and examples of abnormal findings in myasthenia gravis and congenital myasthenia are presented.
This document describes several classification systems for analyzing electromyography (EMG) results:
1. It classifies the degree of acute or subacute denervation seen on EMG as slight, moderate, or severe based on the duration of symptoms and EMG findings like fibrillation potentials and insertional activity.
2. It provides criteria for possible, probable, or definite myopathy based on spontaneous activity, motor unit potential morphology and instability, and involvement of muscle groups on EMG.
3. It outlines a quantitative EMG scoring system for evaluating myopathic changes with criteria in several categories.
4. It proposes a grading system for axonal and demyelinating peripheral neuropathy based
This document discusses different types of EMG electrodes used to measure jitter, including concentric needle electrodes and single fiber EMG electrodes. It presents data from studies measuring jitter with these electrodes in various muscles. Specifically, it shows jitter measurements are higher with concentric needle electrodes than single fiber electrodes in muscles from myasthenia gravis patients. The document also reviews the sensitivity of different diagnostic tests for myasthenia gravis, with jitter analysis and repetitive nerve stimulation having high sensitivity to detect the condition.
This document discusses various late responses and reflexes that can be measured using electrophysiological testing, including F-waves, A-waves, H-reflexes, and flexion reflexes. It provides information on the generator site, mechanism, and normal values for many of these late responses. Examples of abnormal late responses are shown in various neurological conditions like diabetic neuropathy, radiculopathy, amyotrophic lateral sclerosis, and myasthenia gravis. The document aims to characterize the typical electrophysiological features of late responses and reflexes.
This document discusses electromyography (EMG) techniques for evaluating myopathies. It describes how EMG can detect spontaneous muscle fiber activity like fibrillation potentials, myotonic discharges, and complex repetitive discharges that indicate a myopathy. It also discusses EMG analysis of motor unit potential amplitudes and frequencies, interference patterns, and muscle fiber characteristics like splitting that provide clues about normal and diseased muscle. While EMG is sensitive in detecting many myopathies, it is not always specific for differentiating between specific muscle disease subtypes. EMG combined with other clinical findings can help classify myopathies and distinguish myopathic from neuropathic processes.
The document discusses the use of telemedicine and networks in a neurophysiology laboratory. It describes:
1) How the lab uses networks and servers to share information, store patient data, and allow remote access to testing and reporting systems.
2) Examples of regional and international telemedicine collaborations, including video conferencing for consultations, remote supervision of testing, and quality assurance.
3) The future potential for telemedicine to develop national services, use smaller portable equipment, enable home monitoring, and facilitate international collaboration between individuals and research groups.
This document discusses macro electromyography (EMG), a technique used to study motor unit potentials (MUPs). Macro EMG involves inserting a cannula electrode into a muscle to record the electrical activity from many motor units at once, producing a macro motor unit potential (Macro MUP). The document also mentions multiunit triggered averaging, which averages Macro MUP signals to analyze individual motor unit characteristics from the combined signal.
This document discusses the development of single fiber electromyography (SFEMG) over time. Some key findings from SFEMG research include:
- SFEMG suggested that motor unit fibers are organized randomly rather than in subgroups, challenging previous theories.
- Propagation velocity along muscle fibers was measured, showing it decreases with activity and fatigue.
- The jitter phenomenon at the neuromuscular junction was identified as the source of variability in muscle fiber activation times.
- Technical developments like improved electrodes, filters, triggers and delay lines allowed more accurate measurement and understanding of single muscle fiber properties and motor unit organization.
SFEMG provided new insights into normal and diseased muscle physiology and remains
This document discusses testing for myasthenic disorders through repetitive nerve stimulation (RNS). It provides the RNS protocol of stimulating at 3Hz with 10 stimuli at rest, after 10 seconds of activity, and after 1 minute. Parameters like initial amplitude, decrement, and post-activity amplitude are analyzed. Several muscles are recommended for testing including deltoid, trapezius, and anconeus. Normal confidence limits for decrement in different muscles are provided. Examples of RNS results are shown for normal subjects, severe MG, LEMS, and congenital myasthenia. Potential pitfalls of RNS are also discussed.
1) The document provides guidelines for recording jitter with a concentric needle electrode (CNE), including definitions of acceptable CNE signals, techniques for voluntary and electrical stimulation activation, and potential errors in jitter measurements.
2) Examples are given of CNE recordings from different muscles that demonstrate normal voluntary activation, effects of varying stimulation frequency, axon reflex responses, and individual fiber blocking that is analyzed to determine jitter values.
3) Reference data from a multicenter study establishes normal mean jitter and maximum conduction delay (MCD) limits for different muscles based on CNE recordings.
1) Neurophysiological tests play an important role in diagnosing and monitoring motor neuron disease (MND) such as amyotrophic lateral sclerosis (ALS).
2) Electromyography (EMG) can detect lower motor neuron signs in both clinically affected and unaffected regions, helping to confirm diagnosis and exclude other conditions. It analyzes motor unit potential (MUP) parameters and presence of fibrillation potentials and fasciculation potentials.
3) Nerve conduction studies can exclude other neuropathies but often find only mild or no sensory involvement in ALS patients. Motor unit number estimation quantifies the loss of motor units over time in ALS.
Flag Screening in Physiotherapy Examination.pptxBALAJI SOMA
Ìý
Flag screening is a crucial part of physiotherapy assessment that helps in identifying medical, psychological, occupational, and social barriers to recovery. Recognizing these flags ensures that physiotherapists make informed decisions, provide holistic care, and refer patients appropriately when necessary. By integrating flag screening into practice, physiotherapists can optimize patient outcomes and prevent chronicity of conditions.
Dr. Anik Roy Chowdhury
MBBS, BCS(Health), DA, MD (Resident)
Department of Anesthesiology, ICU & Pain Medicine
Shaheed Suhrawardy Medical College Hospital (ShSMCH)
Solubilization in Pharmaceutical Sciences: Concepts, Mechanisms & Enhancement...KHUSHAL CHAVAN
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This presentation provides an in-depth understanding of solubilization and its critical role in pharmaceutical formulations. It covers:
Definition & Mechanisms of Solubilization
Role of surfactants, micelles, and bile salts in drug solubility
Factors affecting solubilization (pH, polarity, particle size, temperature, etc.)
Methods to enhance drug solubility (Buffers, Co-solvents, Surfactants, Complexation, Solid Dispersions)
Advanced approaches (Polymorphism, Salt Formation, Co-crystallization, Prodrugs)
This resource is valuable for pharmaceutical scientists, formulation experts, regulatory professionals, and students interested in improving drug solubility and bioavailability.
Cardiac Arrhythmia definition, classification, normal sinus rhythm, characteristics , types and management with medical ,surgical & nursing, health education and nursing diagnosis for paramedical students.
Non-Invasive ICP Monitoring for NeurosurgeonsDhaval Shukla
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This presentation delves into the latest advancements in non-invasive intracranial pressure (ICP) monitoring techniques, specifically tailored for neurosurgeons. It covers the importance of ICP monitoring in clinical practice, explores various non-invasive methods, and discusses their accuracy, reliability, and clinical applications. Attendees will gain insights into the benefits of non-invasive approaches over traditional invasive methods, including reduced risk of complications and improved patient outcomes. This comprehensive overview is designed to enhance the knowledge and skills of neurosurgeons in managing patients with neurological conditions.
Invasive systems are commonly used for monitoring intracranial pressure (ICP) in traumatic brain injury (TBI) and are considered the gold standard. The availability of invasive ICP monitoring is heterogeneous, and in low- and middle-income settings, these systems are not routinely employed due to high cost or limited accessibility. The aim of this presentation is to develop recommendations to guide monitoring and ICP-driven therapies in TBI using non-invasive ICP (nICP) systems.
BIOMECHANICS OF THE MOVEMENT OF THE SHOULDER COMPLEX.pptxdrnidhimnd
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The shoulder complex acts as in coordinated fashion to provide the smoothest and greatest range of motion possible of the upper limb.
Combined motion of GH and ST joint of shoulder complex helps in:
Distribution of motion between other two joints.
Maintenance of glenoid fossa in optimal position.
Maintenance of good length tension
Although some amount of glenohumeral motion may occur while the other shoulder articulations remain stabilized, movement of the humerus more commonly involves some movement at all three shoulder joints.
This presentation provides a detailed exploration of the morphological and microscopic features of pneumonia, covering its histopathology, classification, and clinical significance. Designed for medical students, pathologists, and healthcare professionals, this lecture differentiates bacterial vs. viral pneumonia, explains lobar, bronchopneumonia, and interstitial pneumonia, and discusses diagnostic imaging patterns.
💡 Key Topics Covered:
✅ Normal lung histology vs. pneumonia-affected lung
✅ Morphological changes in lobar, bronchopneumonia, and interstitial pneumonia
✅ Microscopic features: Fibroblastic plugs, alveolar septal thickening, inflammatory cell infiltration
✅ Stages of lobar pneumonia: Congestion, Red hepatization, Gray hepatization, Resolution
✅ Common causative pathogens (Streptococcus pneumoniae, Klebsiella pneumoniae, Mycoplasma, etc.)
✅ Clinical case study with diagnostic approach and differentials
🔬 Who Should Watch?
This is an essential resource for medical students, pathology trainees, and respiratory health professionals looking to enhance their understanding of pneumonia’s morphological aspects.