U_4.Medicinal Chemistry 3rd .B pharm 6th sem AKTU.Mansoor Ansari .pdf
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Bachelor of pharmacy. 3rd Year 6th semester Hand writing notes of medicinal chemistry 3rd UNIT 4rh. by DRx Mansoor Ansari. AKTU University Lucknow Unit-IV Antifungal agents: Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin. Syntheti Antifungal agents: Clotrimazole, Econazole, Butoconazole, Oxiconazole Tioconazole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate.* Anti-protozoal Agents: Metronidazole*, Tinidazole, Ornidazole, Diloxanide, lodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine. Anthelmintic: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole, Niclosamide, Oxamniquine, Praziquantel, Ivermectin. Sulphonamides and Sulfones: Historical development, chemistry, classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*, Sulphapyridine, Sulfamethoxazole*, Sulphadiazine, Mefenide acetate, Sulfasalazine. Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole. Sulfones: Dapsone*.
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U_5rth.Medicinal Chemistry 3rd .B.pharm 6th sem AKTU By Mansoor Ansari.pdf
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Unit-V
Introduetion to Drug Design
Various approaches used in drug design.
Physicochemical parameters used in quantitative structure activity relationship (QSAR)
such as partition coefficient,
Hammett's electronic parameter, Taft's steric parameter and
Hansch analysis.
Pharmacophore modeling and docking techniques.
Combinatorial Chemistry: Concept and applications of combinatorial Chemistry: Solid
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Introduction to biopharmaceutics, mechanism of drug absorption, ADME, Transport mechanism of drug absorption.Two compartment open model sulekhappt.x.1
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- How drugs distribute between compartments according to first-order rate constants K12 and K21, and are eliminated from the central compartment at a rate of KE
- Equations that describe drug concentrations in each compartment over time after intravenous or oral administration
- Methods for determining pharmacokinetic parameters like absorption rate constant Ka, distribution and elimination rate constants, and compartment volumes from drug concentration-time data.Herbal drug industry (unit 5)
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Herbs, Herbal Drugs
Present Scope of Herbal Drug Industry
Scope of Herbal Drug Medicine and Industry
Indian Herbal Industry
International Scope of Herbal Medicines
World Wide Herbal Trade
Overview on plant based industries and research institutions in India
List of few herbal drug industries in India
List of few herbal research institution/ centres in India
General Introduction to Herbal Industry
Herbal drugs industry: Present scope and future prospects.
A brief account of plant based industries and institutions involved in work on medicinal and
aromatic plants in India.
Methods for Measurement of bioavailability 
Methods for Measurement of bioavailability pharmacampus
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Which are the Methods for Measurement of bioavailability?- Pharmacokinetic method- Plasma level time studies, Urinary excretion studies.
Pharmacodynamic method: Acute pharmacologic response, Therapeutic response.
Factors Affecting Protein-Binding of Drugs
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1) Multiple dosing leads to drug accumulation until steady state is reached when the drug entering and leaving the system are equal.
2) Loading doses provide rapid target concentrations while maintenance doses maintain therapeutic levels.
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1. The herbal drug industry in India has significant present scope and future prospects due to the increasing demand for herbal medicines that are safer, less toxic, and more affordable than synthetic drugs.
2. India has a large number of plant-based industries and research institutions involved in developing medicinal and aromatic plants, with over 2400 plant species used as raw drugs and 8000 plant varieties used in herbal medicines.
3. The herbal drug market in India is estimated at Rs. 7000 crore currently and is one of the fastest growing sectors due to the popularity of Ayurveda and other traditional Indian medicine systems.ELIMINATION OF DRUGS BIOPHARMACEUTICS
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- The time required to reach steady state being dependent on the drug's half-life, not the infusion rate.
- Using a loading dose for drugs with long half-lives to quickly reach the steady state concentration upon starting infusion.Nonlinear Pharmacokinetics
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