Lassa fever is caused by the Lassa virus and is spread chiefly from rodents to humans. It was first discovered in Nigeria and is highly prevalent in West African countries, where an estimated 300-500,000 cases and 5,000 deaths occur annually. Symptoms include fever, headache, muscle pain and bleeding. Transmission occurs through contact with infected rodent excreta or bodily fluids or inhalation of aerosolized viruses. Prevention focuses on eliminating rodents and maintaining clean households and personal hygiene. While there is no cure, early diagnosis and treatment can reduce mortality.