Working in Dr. Malumbres鈥� laboratory at the CNIO, I have focused in the study of mitosis and how its regulators could be associated with cancer (P茅rez de Castro et al., 2007). Using, as a major tool, genetic mouse models we are validating the role that some of these regulators, specifically Aurora kinases, have as therapeutic targets for cancer treatment (P茅rez de Castro et al., 2008). During this period, I have actively participated in studies on the esential functions of Aurora-A in adult mammals (P茅rez de Castro et al., 2013), the regulation of Aurora kinases by SUMOylation (Fernandez-Miranda et al., 2010; Perez de Castro et al., 2012), the role of Tpx2 in spindle function (Agui...
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