I obtained my Ph.D. degree in Organic Chemistry at the Catholic University of Leuven and started my career in 1997 as a Scientist Medicinal Chemistry at the Janssen Medicinal Chemistry Department in Beerse, contributing to gastrointestinal and inflammation research programs.
After that, I moved into the position of Chemistry Team Leader HDAC Inhibition and contributed to the discovery of R306465, a novel inhibitor of class I histone deacetylases with broad-spectrum anti-tumoral activity, which progressed to Phase I clinical trials. In 2004, I was appointed Program Leader and gained responsibility for the development and implementation of an integrated kinase-platform, which eventually ...
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