2015 Kidney Regeneration & Bioengineering Summit
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Subject-matter experts from different disciplines gathered to provide relevant insights into stem cell and developmental biology, organ system function, and innovative approaches to regenerate or bioengineer a kidney.
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2015 Kidney Regeneration & Bioengineering Summit
- 1. OPENING PRESENTATION Kidney Regeneration & Bioengineering State-of-the-Science Summit
- 2. 6:15 p.m. Structural Basis of Essential Kidney Functions Dennis Brown, Harvard University 6:30 p.m. Experience with Renal Assist Devices Christopher J. Pino, University of Michigan 6:45 p.m. Current State of Transplantation John P. Vella, Maine Medical Center 7:00 p.m. Q&A + Group Discussion Led by SOS Chief Science Coordinators Realistic Expectations: What Clinicians Need Right Now Module 1 Tonights clinical perspective is designed to lay the foundation for tomorrows discussion.
- 3. Thomas Carroll, PhD Department of Nephrology, UT Southwestern Medical Center Leif Oxburgh, DVM, PhD Center for Molecular Medicine, Maine Medical Centre Research Institute How to think about Phase One Strategic Research Goals Module 1 KIDNEY COORDINATORS
- 4. SEPT. 14 & 15, 2015 - AUSTIN, TX Kidney Regeneration & Bioengineering State-of-the-Science Summit
- 5. Laying the Foundation Thank you for participating in the first SOS Kidney Summit, a gathering specifically focused on what its going to take to regenerate or bioengineer a kidney for human transplantation. Identify challenges we need to overcome to advance the science. Prepare a meeting report for stakeholders. Form a working group focused on Phase One Strategic Research Goals. 03 01 02
- 6. Rapid-Learning Modules The Summit is organized into four Rapid-Learning Modules covering key topics. Each module is comprised of 15-minute presentations from subject-matter experts and concludes with a Q&A session. MODULE 1 Realistic Expectations: What Clinicians Need Right Now MODULE 2 Repair: Is It Possible to Build Kidney Tissue In Situ? MODULE 3 Building Blocks: Cell Sources for Tissue Generation MODULE 4 Biological Structure: Issues to Consider in Engineering De Novo Kidney Tissue
- 7. Repair: Is It Possible to Build Kidney Tissue In Situ? Module 2 9:30 a.m. Cellular Approaches Used to Enhance Regeneration in Injured Kidneys Lloyd G. Cantley, MD 9:15 a.m. Lessons Learned From Zebrafish About Regenerating Kidney Tissue Iain A. Drummond, PhD Q&A / Group Discussion 9:45 a.m. 9:00 - 10:30 a.m. | 1HR 30M 9:00 a.m. How Cell Developmental Processes Can Be Reactivated to Repair Damaged Organs Manuel Serrano, PhD
- 8. Module 3 Building Blocks: Cell Sources for Tissue Generation 10:30 a.m. - Noon | 1HR 30M Q&A / Group Discussion 11:15 a.m. 10:30 a.m. Status of Reproducibility, Genetic State and Immune Tolerance of iPSCs and hESCs Samantha Morris, PhD 10:45 a.m. Generating Cell Types Needed for De Novo Nephrogenesis Andrew McMahon, PhD 11:00 a.m. Scientific and Ethical Challenges of Xenotransplantation David K.C. Cooper, MD, PhD, FRCS
- 9. Please enjoy lunch and plan to be back in your seat by 12:55 p.m. We will resume promptly at 1 p.m. LUNCH Noon - 1 p.m. | 1HR
- 10. Module 4 1:00 - 3:45 p.m. | 2HR 45M Biological Structure: Issues to Consider in Engineering De Novo Kidney Tissue 1:00 p.m. Essential Angiogenesis Parameters for De Novo Tissue Generation Ondine Cleaver, PhD 1:15 p.m. Key Glomerulus Features to be Included in Engineered Kidney Tissue Stuart Shankland, MD 1:30 p.m. Pros and Cons of Using a Decellularized ECM to Engineer a De Novo Kidney Jason A. Wertheim, MD, PhD 1:45 p.m. Pros and Cons of Using Artificial Scaffolds to Engineer De Novo Kidney Tissue David Kaplan, PhD 2:00 p.m. Group Discussion 2:45 p.m. Phase One Strategic Research Goals
- 11. Identify Phase One Strategic Research Goals
- 12. Form the Whole Kidney Research Community Please complete the form in your registration packet and give it to an SOS staff member. Disseminate Meeting Report This report will define our starting line and will be shared with a variety of stakeholders. Secure Funding for Research Initiatives Our mission is to raise money to fund high impact research initiatives. 01 02 03 NEXT STEPS
- 13. Thanks to Dr. Carroll and Dr. Oxburgh for their help in organizing and leading todays Summit. And thank you for your participation! Thomas Carroll Chief Science Coordinator, Kidney UT Southwestern University Leif Oxburgh Chief Science Coordinator, Kidney Maine Medical Center Research Institute
Editor's Notes
- #2: Were going to get started, Leif, can you please introduce the speakers in our first module.