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HELICOBACTER
G E N T A J U S U F I
HYRJE
 Helicobacter  bakterie gram negative , form谷 spirale
 Fillimisht an谷tar谷 t谷 gjinis谷 Campylobacter
 N谷 1989 Good谷in  Gjini t谷 re : Helicobacter
 35 specie
Helicobacter
Helicobacteraceae
Campylobacterales
Epsilonproteobacteri
a
Proteobacteria
Bacteria
SPECIET
H. acinonychis
H. anseris
H. aurati
H.baculiformis
H. pylori
H. rappini
H. rodentium
H. salomonis
H. suis
H. trogontum
H. typhlonius
H. brantae
H. canadensis
H. canis
H. cetorum
H. cholecystus
H. cinaedi
H. cynogastricus
H. equorum
H. bilis
H. bizzozeronii
H. felis
H. fennelliae
H. ganmani
H. heilmannii
H. hepaticus
H. mesocricetorum
H. macacae
H. marmotae
H. mastomyrinus
H. mesocricetorum
H. muridarum
H. mustelae
H. pametensis
H. pullorum
Helicobacter Pylori
HELICOBACTER PYLORI
PREZENTIM
ME HELICOBATER PYLORI
Izolimi i par谷  1982 nga Marshall dhe 谷arren
Prezenca e tyre e nd谷rlidhur me inflamacionin e mukoz谷s s谷 stomakut (gastritit kronik ,
adenokarcinom谷 gastrike , ulceren gastrike )
EPIDEMIOLOGJIA
Mbi 60% e subjekteve me mosh谷 mbi 60 vjec t谷
infektuar .
TRANSMISIONI
KARAKTERISTIKAT
MIKROBIOLOGJIKE
MORFOLOGJIA
 Spirale me funde t谷 rrumbullak谷ta
 Mikroaerofilik
 Gram  negativ
 0.5-1.0 um x 2.5- 5.0 um
 4-6 flagjele unipolare (30 um x 2.5 nm )
RESPIRIMI DHE METABOLIZMI
 Menz dhe Hazell sqaruan rrug谷t metabolike
 Aktivitet t谷 glukoz谷 kinaz谷s
 Nuk p谷rdorin karbohidratet (p谷r fermentim ose n谷 m谷nyr谷 oksidative )
 Katabolizmin e D-Glukoz谷s
 Shfaq aktivitet gjat谷 ciklit t谷 ures谷 (nxjerrja e azotit t谷 tep谷rt nga qeliza bakteriale)
 Metabolizmi i aminoacideve nga rrug谷t fermentative
 Aktivitet t谷 acetil koenzim谷 A karboksilaz谷s
 P谷rmbajn谷 granula polifosfatike
KARAKTERISTIKAT KULTURELE DHE
BIOKIMIKE
Rritet n谷 medium t谷 l谷ngsh谷m ose t谷 ngurt谷
Gjak , serum , qymyr druri , miell misri , emulsion i t谷 verdh谷s s谷 vez谷s
Rritet m谷 s谷 miri n谷 kushte mikroaerobike
Inkubacioni n谷 nj谷 atmosfer谷 t谷 (5-20%) CO2 n谷 30 deri n谷 37 属 C
Oksidaz谷 +
Katalaz谷 +
Ureaz谷 +++
MEKANIZMI I PATOGJENEZS
Ureaza. neutralizon aciditetin e lukthit dhe nj谷 stimul i fuqish谷m per aktivizimin e qelizave
fagocituese dhe prodhimin
Interleukina-8 (IL-8) aktivizon
neutrofilet  Aderimi i
neutrofileve
PAV- agjent
ulcerogjenik stimulon
sekrecionet acidike te
stomakut n谷p谷rmjet
receptor谷ve specifik
parietal l谷ndime
mukozale direkt ose
indirekt n谷p谷rmjet
rritjes se sekretimit te
acidit.
Fosfolipa
za A2
dhe C-
prishin
shtresen
mbrojt谷s
e te
fosfolipi
deve n谷
membra
n谷n
apikale
te
qelizave
Lipopolisaharidet- nd谷rveprimin midis Mucines dhe
receptoreve te saj mukozal
Mucinaza -
p谷r巽arjen e
barrier谷s
mukozale
te
stomakut.
Citotoksina
vakuolizuese
-vakuola
acidike n谷
citoplazm谷n
e qelizave
eukariotike
Gjeni qe e
kodon : Cag
Apoptoza
Katalaza dhe
superoksid
dismutaza ( e
mbrojne nga
fagocitimi ,
shkaterrojne
leukocitet
polimorfonukleare)
Helicobacter Pylori
DIAGNOSTIFIKIMI
Biopsia e
mukoz谷s
s谷 lukthit
Prova e
ureaz谷s
Diagnoza
indirekte
serologjike
(igG)
Testi i
ures谷
TRAJTIMI (NDJESHMRIA NDAJ
KIMIOPREPARATEVE)
Amoxicilin
Metronidalzol
Tetraciklin谷s,
Tinidazoli ,
Krip谷rat e bismuthit
Klaritromicin
Helicobacter Pylori

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Helicobacter Pylori

  • 1. HELICOBACTER G E N T A J U S U F I
  • 2. HYRJE Helicobacter bakterie gram negative , form谷 spirale Fillimisht an谷tar谷 t谷 gjinis谷 Campylobacter N谷 1989 Good谷in Gjini t谷 re : Helicobacter 35 specie
  • 4. SPECIET H. acinonychis H. anseris H. aurati H.baculiformis H. pylori H. rappini H. rodentium H. salomonis H. suis H. trogontum H. typhlonius H. brantae H. canadensis H. canis H. cetorum H. cholecystus H. cinaedi H. cynogastricus H. equorum H. bilis H. bizzozeronii H. felis H. fennelliae H. ganmani H. heilmannii H. hepaticus H. mesocricetorum H. macacae H. marmotae H. mastomyrinus H. mesocricetorum H. muridarum H. mustelae H. pametensis H. pullorum
  • 7. PREZENTIM ME HELICOBATER PYLORI Izolimi i par谷 1982 nga Marshall dhe 谷arren Prezenca e tyre e nd谷rlidhur me inflamacionin e mukoz谷s s谷 stomakut (gastritit kronik , adenokarcinom谷 gastrike , ulceren gastrike )
  • 8. EPIDEMIOLOGJIA Mbi 60% e subjekteve me mosh谷 mbi 60 vjec t谷 infektuar .
  • 11. MORFOLOGJIA Spirale me funde t谷 rrumbullak谷ta Mikroaerofilik Gram negativ 0.5-1.0 um x 2.5- 5.0 um 4-6 flagjele unipolare (30 um x 2.5 nm )
  • 12. RESPIRIMI DHE METABOLIZMI Menz dhe Hazell sqaruan rrug谷t metabolike Aktivitet t谷 glukoz谷 kinaz谷s Nuk p谷rdorin karbohidratet (p谷r fermentim ose n谷 m谷nyr谷 oksidative ) Katabolizmin e D-Glukoz谷s Shfaq aktivitet gjat谷 ciklit t谷 ures谷 (nxjerrja e azotit t谷 tep谷rt nga qeliza bakteriale) Metabolizmi i aminoacideve nga rrug谷t fermentative Aktivitet t谷 acetil koenzim谷 A karboksilaz谷s P谷rmbajn谷 granula polifosfatike
  • 13. KARAKTERISTIKAT KULTURELE DHE BIOKIMIKE Rritet n谷 medium t谷 l谷ngsh谷m ose t谷 ngurt谷 Gjak , serum , qymyr druri , miell misri , emulsion i t谷 verdh谷s s谷 vez谷s Rritet m谷 s谷 miri n谷 kushte mikroaerobike Inkubacioni n谷 nj谷 atmosfer谷 t谷 (5-20%) CO2 n谷 30 deri n谷 37 属 C Oksidaz谷 + Katalaz谷 + Ureaz谷 +++
  • 14. MEKANIZMI I PATOGJENEZS Ureaza. neutralizon aciditetin e lukthit dhe nj谷 stimul i fuqish谷m per aktivizimin e qelizave fagocituese dhe prodhimin Interleukina-8 (IL-8) aktivizon neutrofilet Aderimi i neutrofileve PAV- agjent ulcerogjenik stimulon sekrecionet acidike te stomakut n谷p谷rmjet receptor谷ve specifik parietal l谷ndime mukozale direkt ose indirekt n谷p谷rmjet rritjes se sekretimit te acidit. Fosfolipa za A2 dhe C- prishin shtresen mbrojt谷s e te fosfolipi deve n谷 membra n谷n apikale te qelizave Lipopolisaharidet- nd谷rveprimin midis Mucines dhe receptoreve te saj mukozal Mucinaza - p谷r巽arjen e barrier谷s mukozale te stomakut. Citotoksina vakuolizuese -vakuola acidike n谷 citoplazm谷n e qelizave eukariotike Gjeni qe e kodon : Cag Apoptoza Katalaza dhe superoksid dismutaza ( e mbrojne nga fagocitimi , shkaterrojne leukocitet polimorfonukleare)
  • 16. DIAGNOSTIFIKIMI Biopsia e mukoz谷s s谷 lukthit Prova e ureaz谷s Diagnoza indirekte serologjike (igG) Testi i ures谷