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HYPERTENSION
1. Hypertension is defined as persistently elevated arterial blood pressure (BP).
2. Hypertension, also known as high blood pressure, is a chronic medical condition in which the force of blood against the artery walls is consistently too high, increasing the risk of heart disease, stroke, and other health complications.
3. WHO Definition of Hypertension
a. According to the World Health Organization (WHO), hypertension is defined as:
Systolic Blood Pressure (SBP) 140 mmHg
Diastolic Blood Pressure (DBP) 90 mmHg
b. Based on repeated measurements under standardized conditions.
Risk factors
Obesity A sedentary lifestyle
Diabetes mellitus High intakes of salt or alcohol
Family history Stress
Cigarette smoking Low birth weight
Hypertension is described as essential (primary, idiopathic) or secondary to other diseases.
Irrespective of the cause, hypertension commonly affects the kidneys.
Essential hypertension
1. A condition of persistently elevated blood pressure without a known secondary cause, often associated with genetic predisposition and lifestyle factors.
Benign (chronic) hypertension
1. The rise in blood pressure is usually slight to moderate and continues to rise slowly over many years.
2. Sometimes complications, such as heart failure, cerebrovascular accident or myocardial infarction are the first indication of hypertension, but often the condition is symptomless and is only discovered during a routine examination.
Malignant (accelerated) hypertension
1. This is a rapid and aggressive acceleration of hypertensive disease.
2. Diastolic pressure in excess of 120 mmHg is common.
3. The effects are serious and quickly become apparent, e.g. haemorrhages into the retina, papilloedema (oedema around the optic disc), encephalopathy (cerebral oedema) and progressive renal disease, leading to cardiac failure.
Secondary hypertension
Hypertension resulting from other diseases accounts for 5% of all cases.
I. Kidney disease
Raised blood pressure is a complication of many kidney diseases. In kidney disease, there is salt and water retention, sometimes with excessive renin activity.
II. Endocrine disorders
a) Adrenal cortex
Secretion of excess aldosterone and cortisol stimulates the retention of excess sodium and water by the kidneys, raising the blood volume and pressure.
b) Adrenal medulla
Secretion of excess adrenaline (epinephrine) and noradrenaline (norepinephrine) raises blood pressure, e.g. phaeochromocytoma .
III. Stricture of the aorta
Hypertension develops in branching arteries proximal to the site of a stricture, e.g congenital
coarctation.
IV. Drug treatment
Hypertension may be a side-effect of some drugs, e.g. corticosteroids and oral contraceptives.
Effects and complications of hypertension
The effects of long-standing and progressively rising blood pressure are serious.
Hypertension predisposes to atherosclerosis and has specific effects on particular organs.
Heart
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Department of Medical Laboratory Sciences,
Regional Institute of Paramedical and Nursing (RIPANS),
Undertaken by the Ministry of Health and Family Welfare (MoHFW), Govt. of India
LAB MANUAL APPLIED HEMATOLOGY
M.Sc. Medical Laboratory Sciences (Blood Banking)
Department of Medical Lab Sciences
Regional Institute of Paramedical and Nursing (RIPANS)
Undertaken by the Ministry of Health and Family Welfare (MoHFW), Govt. of India
Program Details:
Program Name: M.Sc. MLS (Blood Banking)
Semester: 2
Batch: 2024
Subject Name: Applied Hematology
Subject Code: MLTH-P206
About this Lab Manual:
This Lab Manual on Applied Hematology is designed to serve as a comprehensive practical guide for M.Sc. Medical Laboratory Sciences (Blood Banking) students at RIPANS. It provides a structured framework for laboratory techniques, diagnostic methodologies, and applied hematological procedures, ensuring a hands-on approach to understanding blood-related disorders and transfusion science.
This manual covers advanced hematological investigations, staining techniques, bone marrow examinations, and specialized blood testing methods essential for a professional career in blood banking and hematology laboratories. Each experiment is presented with a detailed principle, methodology, interpretation guidelines, and viva questions, allowing students to grasp fundamental and advanced concepts with ease.
Key Features of this Manual:
鏝 Step-by-Step Experimental Procedures Clear, well-structured protocols to enhance laboratory skills.
鏝 Principles & Applications Explanation of core hematological principles and their real-world applications.
鏝 Clinical Relevance Interpretation of lab findings in diagnosing hematological disorders.
鏝 Observation & Analysis Structured observation tables to record findings systematically.
鏝 Viva Questions & Answer Key Helps in exam preparation and enhances conceptual clarity.
鏝 Reference Textbooks Standard books suggested for further in-depth learning.
Who Should Use This Manual?
This manual is intended for M.Sc. Medical Laboratory Sciences (Blood Banking) students and faculty members at RIPANS. It is a valuable resource for trainees, researchers, and professionals in hematology and transfusion medicine.
Through this structured and practical approach, students will develop a deeper understanding of hematological investigations, laboratory techniques, and diagnostic procedures, ultimately preparing them for clinical, research, and diagnostic settings.
For academic and professional use only.DIABETES BY DR. DOLLY RANI [Autosaved] [Autosaved].pptx![DIABETES BY DR. DOLLY RANI [Autosaved] [Autosaved].pptx](https://cdn.slidesharecdn.com/ss_thumbnails/diabetesbydr-250304142525-067925e5-thumbnail.jpg?width=560&fit=bounds)
DIABETES BY DR. DOLLY RANI [Autosaved] [Autosaved].pptxdrdollyrani2024
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