Monobactam
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Monobactams are 硫-lactam compounds that contain an isolated 硫-lactam ring not fused to another ring, making them effective only against aerobic Gram-negative bacteria like Neisseria and Pseudomonas. Examples include aztreonam, tigemonam, nocardicin A, and tabtoxin. Potential adverse effects are skin rash, abnormal liver functions, and risk of seizures in susceptible individuals.
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thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
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RAJIV GANDHI PROUDYOGIKI VISHWAVIDYALAYA
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In partial fulfillment of requirement for
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Monobactam
- 1. Monobactam Monobactams are 硫-lactam compounds wherein the 硫-lactam ring is alone and not fused to another ring, in contrast to most other 硫-lactams. They are effective only against aerobic Gram-negative bacteria. (e.g., Neisseria, Pseudomonas).
- 2. Other examples of monobactams are aztreonam. tigemonam, nocardicin A, and tabtoxin.
- 3. Aztreonam. (The four-membered ring at the bottom is the 硫-lactam. There is a second thiazole ring, but it is not fused to the 硫-lactam ring.)
- 4. Tigemonam
- 5. Adverse effects to monobactams can include skin rash and occasional abnormal liver functions. They have no cross-hypersensitivity reactions with penicillin but like penicillins can trigger seizures in patients with history of seizures.