Pharmacokinetics icu setting_2007_nagoya
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This document discusses the calculation of drug concentrations in the body using pharmacokinetic parameters like volume of distribution (Vd) and drug dosage. It provides examples of calculating predicted drug concentrations in blood for different drugs and dosages based on a patient's weight and estimated Vd. The goal of these calculations is to determine appropriate drug dosing to achieve therapeutic concentrations without causing toxicity.
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Pharmacokinetics icu setting_2007_nagoya
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- 9. 9 L
- 10. 10 L 100mg 2μg/ml(=2mg/L) 100(mg)/2(mg/L)=50L 1kg 1L
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- 12. 12 (L)= (mg)/ (mg/L) Vd (L/kg) 0.3 0.5-1 >1
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- 16. 16 1-1.5mg/kg 17mg/kg
- 17. 17 1.5mg/kg × 10 50kg Vd ×Vd 50kg×1.1L/kg L kg×1.5mg/kg× mg mg / L mg/L =μg/ml
- 18. 18 1.5mg/kg × 50kg Vd Vd=1.1L/kg ×Vd 50kg×1.1L/kg 55 L kg×1.5mg/kg× 150 mg 150 mg / 55 L 2.7 mg/L =μg/ml 2-5μg/ml
- 19. 19 17mg/kg 3.6 30 50kg Vd ×Vd 50kg×1.9L/kg L kg×17mg/kg mg mg / L mg/L =μg/ml
- 20. 20 17mg/kg 50kg Vd Vd=1.9L/kg ×Vd 50kg×1.9L/kg 95 L kg×17mg/kg 850 mg 850 mg / 95 L 8.95 mg/L =μg/ml 4-10μg/ml
- 21. 21 50kg 250mg 50kg Vd ×Vd 50kg×0.5L/kg L 250mg mg / L mg/L =μg/ml →
- 22. 22 50kg 250mg 50kg Vd Vd=0.5L/kg ×Vd 50kg×0.5L/kg 25 L 250mg 250 mg / 25 L 10 mg/L =μg/ml 5-15μg/ml >20μg/ml → 10μg/ml 20μg/ml
- 23. 23 1-1.5mg/kg 17mg/kg
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- 26. 26 (CCB) loading dose
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- 28. 28 4 5
- 29. 29 4 5 95%
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- 31. 31 H2 blocker iatrogenic
- 32. 32 4 iatrogenic