際際滷

際際滷Share a Scribd company logo
BioMedical油Precision油Engineering油Lab
Ichiro油Sakuma,油Estuko Kobayshi,油Takehiro Ando
School油of油Engineering,油The油University油of油Tokyo

 Computer油Aided油Surgery
 Robotics油for油CAS
 Electrophysiology油of油Arrhythmia

real time segmentation

log
5-ALA
2.8亮micro-Laser
鐚鐚ALA油for油intraoperative油identification油of油malignant油
brain油tumor
 5Aminolevulinic油Acid油(5ALA)油and油
Protoporphyrin IX油(PpIX)
 5ALA油accumulates油on油tumors,油and油
metabolizes油to油PpIX in油malignant油glioma.
 PpIX is油a油fluorescent油substance;油
emits油red油fluorescence油when油it油is油
excited油by油blue油light.

tumor

brain surface

5-ALA

PpIX

(Friesen et al, 2002)
5-ALA leads to intracellular
accumulation of fluorescent
prophyrins PpIX in malignant
gliomas
System油configuration

Medical油Image油Analysis油16(3):油13618415.

3
Laser油ablation油of油porcine油brain油stained油with油5ALA
(Noguchi油M.,油2006)油

Agar油gel油with油intralipid油
and油Pp9(10[亮g/ml])
 NEDO(New油Energy油and油Industrial油Technology油Development油
Organization)油Intelligent油Surgical油Instrument油Project
Subproject:油Intelligent油surgical油instrument油for油minimally油
invasive油thoracic油surgery
 Periodic油research油meetings油among油researchers油in油clinical油
medicine,油engineering,油and油industries
 Design油modification油through油tests油using油prototypes油in油repeated油
workshops

http://www.nedo.go.jp/news/press/AA5_100145.html
http://www.youtube.com/watch?v=aKdE8C8KcJI
Movie
Ventricular Tachycardia (VT), Ventricular fibrillation 鐚VF)
 Major cause of sudden cardiac death
 Reentrant excitation is one of the major cause of VT and VF

 Spiral is characterized by progressively
increasing radius of curvature toward the
center.
 Conduction velocity slows down toward the
center because of progressive decrease of
the source/sink ratio and eventually
becomes zero.
 At the center, various phases of excitation
meet and formulate singular point. The
wavefront meets its own refractory tail and
rotation persists around this pivot point.
7
Excitation
light

Excited

Resting

F

500 nm

600
nm

Wave
length

Light Intensity

Light strength

Optical油Mapping油of油Cardiac油Excitations

Background
Component(F)
Action Potential
Amplitude(
F)
F/F < 10%

Use油of油voltage油sensitive油dye:油Di4ANEPPS
Suppression油of油contraction油by油2,3butandione油monoxime(BDM)

8

Time
Application of visual feedback to eletctrical stimulation

High油Speed

9
10
Ad

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Biomedical Precision Engineering Lab.