Hernandez ashg 2016_sharerdhernandThe document discusses how human evolutionary history has increased the role of rare genetic variants in complex phenotypes. It finds that the majority of human genetic variation associated with traits is due to rare variants rather than common variants, as previously thought. Additionally, rare variants tend to have larger effects on traits than common variants. The role of rare variants is enhanced by human demographic histories involving population growth and natural selection. Analysis of gene expression data from multiple populations supports the conclusion that rare variants explain more phenotypic variation than common variants for many genes.
MIM 8th Annual Conference Sponsorship Packetmedicalmentor70Join the MIM Team and the Science Pathfinders Program for the Health and Science Expo: Empowerment and Education on Saturday, December 13, 2014 from 8am-3pm for students from elementary school through college, parents and educators. We need your help to sponsor children to attend the conference. Thank you in advance!
Hernandez ASHG 2015rdhernandThis document summarizes research on the genetic basis of gene expression patterns. Simulations show that rare variants account for a large proportion of heritability for gene expression, with over 50% of heritability due to rare variants for most genes. Analyzing rare and common variants separately reduces bias in heritability estimates. The results provide insights into the evolutionary dynamics of complex traits and a tight coupling between genetic effect sizes and evolutionary parameters.
5 min spn_audioscriptVerioska CarreñoEste documento presenta un resumen de las lecciones en el libro 5-Minute Spanish. Incluye diálogos y frases útiles para saludos, presentaciones, preguntas sobre el origen y el idioma, números, hora, fecha, familia y comidas. Explica vocabulario clave y proporciona ejemplos de conversaciones sobre estos temas diarios en español para principiantes.
Hernandez ashg 2016_sharerdhernandThe document discusses how human evolutionary history has increased the role of rare genetic variants in complex phenotypes. It finds that the majority of human genetic variation associated with traits is due to rare variants rather than common variants, as previously thought. Additionally, rare variants tend to have larger effects on traits than common variants. The role of rare variants is enhanced by human demographic histories involving population growth and natural selection. Analysis of gene expression data from multiple populations supports the conclusion that rare variants explain more phenotypic variation than common variants for many genes.
MIM 8th Annual Conference Sponsorship Packetmedicalmentor70Join the MIM Team and the Science Pathfinders Program for the Health and Science Expo: Empowerment and Education on Saturday, December 13, 2014 from 8am-3pm for students from elementary school through college, parents and educators. We need your help to sponsor children to attend the conference. Thank you in advance!
Hernandez ASHG 2015rdhernandThis document summarizes research on the genetic basis of gene expression patterns. Simulations show that rare variants account for a large proportion of heritability for gene expression, with over 50% of heritability due to rare variants for most genes. Analyzing rare and common variants separately reduces bias in heritability estimates. The results provide insights into the evolutionary dynamics of complex traits and a tight coupling between genetic effect sizes and evolutionary parameters.
5 min spn_audioscriptVerioska CarreñoEste documento presenta un resumen de las lecciones en el libro 5-Minute Spanish. Incluye diálogos y frases útiles para saludos, presentaciones, preguntas sobre el origen y el idioma, números, hora, fecha, familia y comidas. Explica vocabulario clave y proporciona ejemplos de conversaciones sobre estos temas diarios en español para principiantes.
Dream of Detroit Community Meeting PresentationdreamofdetroitOn Sunday, June 22, members of the metro Detroit Muslim community met at the Muslim Center Mosque and Community Center to talk about Dream of Detroit--a vision for revitalizing a westside neighborhood. This presentation was given to introduce attendees to the project.
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Integrated lesson plan (2)lanie1501The lesson plan outlines objectives, materials, and procedures for teaching preschool students about the five senses through various activities like songs, pictures, sensory exploration, and role playing. The objectives are for students to identify the five senses, their functions, and appreciate their importance. The procedures involve preparatory, developmental, and assessment activities to engage students in learning about sight, smell, hearing, taste, and touch.
Digital systems day_3Pedro Alberto Rocha LariosThis document provides details about a digital systems course being offered in the summer of 2014. The instructor is Juan Pablo BRACAMONTESDEL TORO and the course will take place from 9-11 AM in the Smart Room. The objective is to review the basics of digital systems from signals through design and hardware description languages like VHDL. The agenda for Day 3 includes Boolean algebra, canonical forms, and Karnaugh maps. References for the course are listed as a Digital Design textbook and an MIT OpenCourse on digital systems laboratories.
How do we teach sciencelanie1501Science teachers have an exciting opportunity to teach children about how the world works through exploration and hands-on activities rather than just facts. As a preschool teacher, lesson planning is important to engage different types of learners through varied activities suited to their levels and intelligences. Bringing real plants and examples into the classroom or doing outdoor activities can help children easily grasp lessons and stay engaged by discovering ideas on their own. Techniques like using realia, music, role play and peer learning help teach science in a meaningful way, while unavailable or expensive materials present more challenges.
Brain based lesson planlanie1501This lesson plan aims to teach students about the basic parts of flowers. It includes objectives, subject matter, procedures, and evaluations. The procedures involve identifying flower parts through pictures and activities. Students will count petals, compare sizes, role play care, and sing a song. They will also visit the school garden and draw their favorite flower.
Psed 2 ( theorist)1lanie1501Lev Vygotsky's socio-cultural theory emphasizes the important role that social interaction plays in cognitive development. According to Vygotsky, learning cannot be fully understood without considering the social and cultural context. He believed learners should be provided socially rich environments to explore knowledge with teachers, experts, and peers. Vygotsky introduced the concept of scaffolding, where teachers provide appropriate assistance to help learners accomplish tasks. As a preschool teacher, the author uses scaffolding techniques like modeling instructions and peer tutoring to help children complete activities like making a plant mobile, without doing the work for them. This socio-cultural theory informs effective teaching strategies that enhance learner abilities and maximize learning.
Hernandez smbe 2015rdhernandThis document summarizes research on modeling the effects of background selection on genetic variation using non-equilibrium demographic models. It discusses how background selection reduces genetic diversity and increases the proportion of rare variants by purging deleterious mutations. Forward simulations are used to model these effects over time and under different demographic scenarios, showing that background selection has a greater impact when populations are not at equilibrium. The approach is applied to human genetic data, finding that inferred demographic histories are altered depending on the level of background selection in genomic regions.
Brain based lesson planlanie1501This lesson plan aims to teach students about the basic parts of flowers. It includes objectives, subject matter, procedures, and evaluations. The procedures involve identifying flower parts through pictures and activities. Students will count petals, compare sizes, role play care, and sing a song. They will also visit the school garden and draw their favorite flower.
Integrated lesson plan (2)lanie1501The lesson plan outlines objectives, materials, and procedures for teaching preschool students about the five senses through various activities like songs, pictures, sensory exploration, and role playing. The objectives are for students to identify the five senses, their functions, and appreciate their importance. The procedures involve preparatory, developmental, and assessment activities to engage students in learning about sight, smell, hearing, taste, and touch.
