Angina pectoris is chest pain caused by an imbalance between the heart's oxygen demand and the oxygen supplied by the coronary vessels. There are three main types: classical angina due to atherosclerosis, variant angina due to coronary vasospasm, and unstable angina involving progressive occlusion of a coronary artery. Antianginal drugs include nitrates like nitroglycerin that relieve pain by dilating blood vessels, beta-blockers, calcium channel blockers, and others. Nitrates work by releasing nitric oxide which causes smooth muscle relaxation and dilation of veins, arteries, and coronary vessels to redistribute blood flow. Calcium channel blockers work by blocking calcium channels in smooth muscle to decrease contraction.
This document discusses antimicrobial drugs (AMA), problems with their use like toxicity and resistance, and ways to prevent resistance like using drugs for the appropriate time and in combinations. It also covers patient factors that impact AMA use and chemoprophylaxis. Specifically, it defines cotrimoxazole as a combination of sulfamethaxazole and trimethaprim that acts synergistically to block folate metabolism, lists its uses like UTIs and pneumocystis infections in AIDS, and adverse effects like GI issues, folate deficiency, and hemolytic anemia in neonates.
Cough is a protective reflex caused by stimulation of sensory nerves in the respiratory tract mucosa. It serves to expel respiratory secretions induced by infections or irritants like smoke. There are three main types of drugs used to treat cough - expectorants to increase mucus secretion and thinning, mucolytics to break up thick mucus, and antitussives/cough suppressants to reduce cough reflex. Antihistamines work by blocking the H1 receptor and antagonizing the effects of the chemical histamine, which is involved in allergic responses. First and second generation antihistamines are used to treat allergic diseases by reducing symptoms like itching, as well as other conditions involving histamine release such as
Antiplatelet drugs like aspirin work by interfering with platelet function and thromboxane synthesis. Aspirin is a thromboxane synthase inhibitor that irreversibly inhibits this enzyme, reducing thromboxane production and platelet aggregation. It is commonly used at low doses of 75-150 mg daily to prevent myocardial infarction and stroke in high-risk patients by its antiplatelet effects.
Fibrinolytics, or thrombolytics, are drugs used to dissolve blood clots by lysing fibrin. Examples include streptokinase, urokinase, and alteplase. They are used to treat acute myocardial infarction, deep vein thrombosis, and pulmonary embolism. Antifibrinolytics like epsilon amino-caproic acid and tranexaemic acid inhibit fibrinolytic activity and are used to control bleeding from overdose of fibrinolytics or due to excessive fibrinolytic activity during surgery or complications of surgery, tooth extraction, menorrhagia, and hematuria.
Anticoagulants are drugs that reduce the coagulability of blood. They can be used in vitro in laboratory settings or in vivo in patients. Common anticoagulants include heparin, low molecular weight heparins like enoxaparin, and oral anticoagulants like warfarin. Heparin works by binding to and activating antithrombin III, which then inhibits various clotting factors. Warfarin interferes with vitamin K dependent clotting factor synthesis. Both can cause bleeding as an adverse effect. Anticoagulants are used to treat conditions like deep vein thrombosis, pulmonary embolism, and acute myocardial infarction.
Diuretics are drugs that cause a net loss of sodium and water in urine. They are classified as high efficacy loop diuretics, medium efficacy thiazide diuretics, and weak adjunctive diuretics. Loop diuretics act in the thick ascending limb of the loop of Henle to inhibit sodium reabsorption. Thiazide diuretics act in the distal convoluted tubule. Carbonic anhydrase inhibitors act in the proximal convoluted tubule. Potassium sparing diuretics act in the late distal tubule and collecting duct. Common uses include treating hypertension, heart failure, kidney disease, calcium stones, and poisoning. Adverse effects can include hypokalemia, hy
Statins like simvastatin and atorvastatin work by inhibiting HMG-CoA reductase and lowering cholesterol production in the liver. Bile acid sequestrants such as cholestyramine and colestipol bind bile acids in the gut. Ezetimibe decreases intestinal cholesterol absorption while statins lower endogenous production. Nicotinic acid and fibric acid derivatives like gemfibrozil and fenofibrate lower triglycerides and raise HDL. All drug classes have potential side effects involving the liver, muscles or gastrointestinal system. Statins are commonly used to treat familial hypercholesterolemia and combined hyperlipidemia.
Congestive heart failure occurs when the heart cannot pump enough blood to meet the body's needs. Symptoms result from blood backing up in the heart and lungs. The main drugs used to treat CHF are ACE inhibitors, ARBs, diuretics, beta-blockers, digoxin, and vasodilators. Digoxin works by inhibiting the sodium-potassium pump, raising intracellular calcium levels, increasing calcium release from the sarcoplasmic reticulum, and enhancing the actin-myosin interaction to strengthen contraction and cardiac output.
This document provides information on the treatment of bronchial asthma, including the classification and mechanisms of action of the major drug classes used. The main drug classes discussed are bronchodilators like beta-2 agonists, anticholinergics, and methylxanthines; corticosteroids; mast cell stabilizers; and leukotriene modulators. Routes of administration, indications, benefits, limitations and side effects are summarized for the major drugs in each class.
This document discusses antihypertensive drugs, classification of blood pressure, and treatment of hypertension. It describes the different classes of antihypertensive drugs including ACE inhibitors, ARBs, calcium channel blockers, diuretics, sympatholytics, and vasodilators. It provides details on their mechanisms of action, therapeutic uses, advantages, adverse effects, and drug interactions. The document also covers non-pharmacological approaches for hypertension and guidelines for selection and combination of antihypertensive drugs based on individual patient factors.
Консалтинг и аудит информационной безопасностиКРОК
?
Недостаточность и плохая проработка вопросов обеспечения информационной безопасности (ИБ) компании, ее методических и концептуальных основ может пагубно влиять на ее бизнес-процессы, затрудняя их выполнение и снижая эффективность.
Подробнее на http://www.croc.ru/solution/services/consulting/it-safety/
Peptic ulcers are caused by a loss of gastric or duodenal mucosa leading to ulcer formation. Drugs used to treat peptic ulcers work by reducing acid secretion, neutralizing acid, protecting the ulcer, or eradicating Helicobacter pylori infection. Common classes of drugs include H2 receptor antagonists, proton pump inhibitors, antacids, sucralfate, bismuth subcitrate, and multi-drug regimens for H. pylori. The document provides details on the mechanisms, uses, and side effects of these various drug classes.
Lisosom adalah organel yang ditemukan pada tahun 1950 oleh Christian de Duve yang berperan dalam mencerna makromolekul. Lisosom terdiri dari membran tunggal dan berisi berbagai enzim hidrolitik yang digunakan untuk melakukan endositosis, autofagi, dan fagositosis. Kelainan metabolisme lisosom dapat menyebabkan penyakit penyimpangan lisosom.
Parkinson's disease is a progressive neurodegenerative disorder characterized by four main symptoms: bradykinesia, muscular rigidity, resting tremors, and loss of postural reflexes. It results from the loss of dopaminergic neurons in the substantia nigra, disrupting the balance between inhibitory dopaminergic and excitatory cholinergic neurons. Treatment involves drugs that influence the dopaminergic or cholinergic systems in the brain. Levodopa is often used but must be combined with carbidopa to reduce peripheral side effects. Long term levodopa therapy can cause abnormal movements or behavioral issues.
This document discusses antiemetic, antidiarrheal, and laxative agents. It provides examples of common antiemetic drugs like ondansetron and metoclopramide that are used to treat nausea and vomiting from chemotherapy, motion sickness, and other causes. Antidiarrheal drugs mentioned include loperamide and diphenoxylate that decrease motility to control non-infectious diarrhea. Laxatives discussed stimulate the GI tract and include bisacodyl, senna, and magnesium sulfate to treat constipation from low fiber diets, bed rest, or to prepare for certain medical procedures.
Haematinics are agents required for blood formation including iron, vitamin B12, and folic acid. Oral iron preparations include ferrous sulfate, ferrous gluconate, and ferrous fumarate, while parenteral preparations are iron dextran and iron sorbitol citric acid complex. Adverse effects of oral iron include gastrointestinal issues and staining, while parenteral iron can cause pain, pigmentation, and reactions. Iron is used to treat and prevent iron deficiency anemia. Vitamin B12 preparations include cyanocobalamin and hydroxocobalamin and are used to treat deficiencies causing megaloblastic anemia, especially in pernicious anemia. Folic acid preparations are
Congestive heart failure occurs when the heart cannot pump enough blood to meet the body's needs. Symptoms result from blood backing up in the heart and lungs. The main drugs used to treat CHF are ACE inhibitors, ARBs, diuretics, beta-blockers, digoxin, and vasodilators. Digoxin works by inhibiting the sodium-potassium pump, raising intracellular calcium levels, increasing calcium release from the sarcoplasmic reticulum, and enhancing the actin-myosin interaction to strengthen contraction and cardiac output.
This document provides information on the treatment of bronchial asthma, including the classification and mechanisms of action of the major drug classes used. The main drug classes discussed are bronchodilators like beta-2 agonists, anticholinergics, and methylxanthines; corticosteroids; mast cell stabilizers; and leukotriene modulators. Routes of administration, indications, benefits, limitations and side effects are summarized for the major drugs in each class.
This document discusses antihypertensive drugs, classification of blood pressure, and treatment of hypertension. It describes the different classes of antihypertensive drugs including ACE inhibitors, ARBs, calcium channel blockers, diuretics, sympatholytics, and vasodilators. It provides details on their mechanisms of action, therapeutic uses, advantages, adverse effects, and drug interactions. The document also covers non-pharmacological approaches for hypertension and guidelines for selection and combination of antihypertensive drugs based on individual patient factors.
Консалтинг и аудит информационной безопасностиКРОК
?
Недостаточность и плохая проработка вопросов обеспечения информационной безопасности (ИБ) компании, ее методических и концептуальных основ может пагубно влиять на ее бизнес-процессы, затрудняя их выполнение и снижая эффективность.
Подробнее на http://www.croc.ru/solution/services/consulting/it-safety/
Peptic ulcers are caused by a loss of gastric or duodenal mucosa leading to ulcer formation. Drugs used to treat peptic ulcers work by reducing acid secretion, neutralizing acid, protecting the ulcer, or eradicating Helicobacter pylori infection. Common classes of drugs include H2 receptor antagonists, proton pump inhibitors, antacids, sucralfate, bismuth subcitrate, and multi-drug regimens for H. pylori. The document provides details on the mechanisms, uses, and side effects of these various drug classes.
Lisosom adalah organel yang ditemukan pada tahun 1950 oleh Christian de Duve yang berperan dalam mencerna makromolekul. Lisosom terdiri dari membran tunggal dan berisi berbagai enzim hidrolitik yang digunakan untuk melakukan endositosis, autofagi, dan fagositosis. Kelainan metabolisme lisosom dapat menyebabkan penyakit penyimpangan lisosom.
Parkinson's disease is a progressive neurodegenerative disorder characterized by four main symptoms: bradykinesia, muscular rigidity, resting tremors, and loss of postural reflexes. It results from the loss of dopaminergic neurons in the substantia nigra, disrupting the balance between inhibitory dopaminergic and excitatory cholinergic neurons. Treatment involves drugs that influence the dopaminergic or cholinergic systems in the brain. Levodopa is often used but must be combined with carbidopa to reduce peripheral side effects. Long term levodopa therapy can cause abnormal movements or behavioral issues.
This document discusses antiemetic, antidiarrheal, and laxative agents. It provides examples of common antiemetic drugs like ondansetron and metoclopramide that are used to treat nausea and vomiting from chemotherapy, motion sickness, and other causes. Antidiarrheal drugs mentioned include loperamide and diphenoxylate that decrease motility to control non-infectious diarrhea. Laxatives discussed stimulate the GI tract and include bisacodyl, senna, and magnesium sulfate to treat constipation from low fiber diets, bed rest, or to prepare for certain medical procedures.
Haematinics are agents required for blood formation including iron, vitamin B12, and folic acid. Oral iron preparations include ferrous sulfate, ferrous gluconate, and ferrous fumarate, while parenteral preparations are iron dextran and iron sorbitol citric acid complex. Adverse effects of oral iron include gastrointestinal issues and staining, while parenteral iron can cause pain, pigmentation, and reactions. Iron is used to treat and prevent iron deficiency anemia. Vitamin B12 preparations include cyanocobalamin and hydroxocobalamin and are used to treat deficiencies causing megaloblastic anemia, especially in pernicious anemia. Folic acid preparations are