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SU-5146(20mg/kg BW s,c.)
S.D rats (BW 180g)
n≥3
In Hypoxia Chamber
4 weeks Normoxia 2 weeks XBD (2mg/kg BW /day) 2 weeks
Imaging (CT scan and CMR)
Haemodeynamics
Tissue collection for
biochemical studies and
histology.

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