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  • 1. §®§Ö§ç§Ñ§ß§Ú§Ù§Þ§í §ß§Ö§â§Ó§ß§à§Û §Ú §Ô§å§Þ§à§â§Ñ§Ý§î§ß§à§Û §â§Ö§Ô§å§Ý§ñ§è§Ú§Ú §ã§ß§Ñ.
  • 2. §³§à§ß: §Õ§Ó§Ú§Ô§Ñ§ä§Ö§Ý§î§ß§à§Û §Ñ§Ü§ä§Ú§Ó§ß§à§ã§ä§Ú §à§ä§Ó§Ö§ä§Ñ §ß§Ñ §â§Ñ§Ù§Õ§â§Ñ§Ø§Ú§ä§Ö§Ý§Ú §à§á§â§Ö§Õ§Ö§Ý§Ö§ß§ß§à§Ö §á§à§Ý§à§Ø§Ö§ß§Ú§Ö §ä§Ö§Ý§Ñ §Ó §á§â§à§ã§ä§â§Ñ§ß§ã§ä§Ó§Ö §à§ä§ß§à§ã§Ú§ä§Ö§Ý§î§ß§à §Ý§Ö§Ô§Ü§Ñ§ñ §à§Ò§â§Ñ§ä§Ú§Þ§à§ã§ä§î
  • 3. §°§ã§à§Ò§Ö§ß§ß§à§ã§ä§Ú §¿§¿§¤, §¿§®§¤ §Ú §¿§°§¤ §Õ§Ý§ñ §â§Ñ§Ù§ß§í§ç §ã§ä§Ñ§Õ§Ú§Û §ã§ß§Ñ §¿§¿§¤ §¿§®§¤ §¿§°§¤ SWS §Ú§Ý§Ú NonREM REM ?§Ó§Ö§â§ä§Ö§Ü§ã? §Ó§Ö§â§Ö§ä§Ö§ß§Ñ
  • 4. §¯§Ö§â§Ó§ß§Ñ§ñ §â§Ö§Ô§å§Ý§ñ§è§Ú§ñ NREM : 1. §¢§Ñ§Ù§Ñ§Ý§î§ß§í§Ö §ñ§Õ§â§Ñ . NREM-on §Ü§Ý§Ö§ä§Ü§Ú: -§Þ§Ö§Õ§Ú§Ñ§ä§à§â - §¤§¡§®§¬ -§ä§Ö§â§Þ§à§é§å§Ó§ã§ä§Ó§Ú§ä§Ö§Ý§î§ß§í§Ö §Ò§Ö§ã§ã§à§ß§ß§Ú§è§Ñ 2. §©§Ñ§Õ§ß§Ú§Û §Ô§Ú§á§à§ä§Ñ§Ý§Ñ§Þ§å§ã. NREM-off §Ü§Ý§Ö§ä§Ü§Ú: -§Þ§Ö§Õ§Ú§Ñ§ä§à§â - §Ô§Ú§ã§ä§Ñ§Þ§Ú§ß §á§â§à§Ò§å§Ø§Õ§Ö§ß§Ú§Ö NREMS
  • 5. 3. Nucleus reticularis §Þ§Ö§Õ§Ú§Ñ§ä§à§â - §¤§¡§®§¬ §³§Ñ 2+ §³§Ñ 2+ - §ã§á§Ñ§Û§Ü§Ú in out Ach §Ô§Ú§á§Ö§â- §á§à§Ý§ñ§â§Ú§Ù§Ñ§è§Ú§ñ §ã§Ö§â§Ú§ñ §±§¥ ?§³§Ñ 2+ - §ã§á§Ñ§Û§Ü§Ú? §ß§Ö§Û§â§à§ß§í NR §¤§¡§®§¬ §ä§Ñ§Ý§Ñ§Þ§à-§Ü§à§â§ä§Ú§Ü§Ñ§Ý§î§ß§í§Ö §ß§Ö§Û§â§à§ß§í §¤§Ú§á§Ö§â§á§à§Ý§ñ§â§Ú§Ù§Ñ-§è§Ú§ñ §³§Ñ 2+
  • 6. §¯§Ö§â§Ó§ß§Ñ§ñ §â§Ö§Ô§å§Ý§ñ§è§Ú§ñ REM §ã§ß§Ñ. 1. mRF REM-W-on §Ü§Ý§Ö§ä§Ü§Ú - §Þ§Ö§Õ§Ú§Ñ§ä§à§â ¨C Ach -§Ñ§Ü§ä§Ú§Ó§ß§à§ã§ä§î §ã§à§á§â§ñ§Ø§Ö§ß§Ñ §ã §à§á§â§Ö§Õ§Ö§Ý§Ö§ß- §ß§í§Þ§Ú §Õ§Ó§Ú§Ø§Ö§ß§Ú§ñ§Þ§Ú §Ô§Ý§Ú§è§Ú§ß 5-HT, NA §¤§¡§®§¬ Ach §Ô§Ý§å§ä§Ñ§Þ§Ñ§ä
  • 7. 2. §Ý§Ñ§ä. RF §Þ§à§ã§ä§Ñ §Ú §Þ§Ö§Õ. RF §á§â§à§Õ§à§Ý§Ô§à§Ó§Ñ§ä§à§Ô§à §Þ§à§Ù§Ô§Ñ REM-on §Ü§Ý§Ö§ä§Ü§Ú - §Ñ§Ü§ä§Ú§Ó§Ú§â§å§ð§ä§ã§ñ §á§â§Ú §à§á§å§ã§Ü§Ñ§ß§Ú§Ú §Ô§à§Ý§à§Ó§í §Ú §å§Þ§Ö§ß§î§ê§Ö§ß§Ú§Ú §ä§à§ß§å§ã§Ñ §Ñ§ß§ä§Ú§Ô§â§Ñ§Ó§Ú§ä§Ñ§è§Ú§à§ß§ß§à§Û §Þ§å§ã§Ü§å§Ý§Ñ§ä§å§â§í -§Þ§Ö§Õ§Ú§Ñ§ä§à§â -? (§Ô§Ý§Ú§è§Ú§ß, §¤§¡§®§¬, §á§Ö§á§ä§Ú§Õ§í) REM-off - §Þ§Ö§Õ§Ú§Ñ§ä§à§â§í ¨C 5-§¯§´ §Ú NA 3. §¤§± §Ú §Á§º. §Á§º §¤§± waking NREM REM
  • 8. PGO - §ã§á§Ñ§Û§Ü§Ú ( ponto-genicular-occipital) §Ý§Ñ§ä§Ö§â§Ñ§Ý§î§ß§à§Ö §Ü§à§Ý§Ö§ß§é§Ñ§ä§à§Ö §ä§Ö§Ý§à §Ù§Ñ§ä§í§Ý§à§é§ß§Ñ§ñ §Ü§à§â§Ñ 4. §±§Ö§â§Ú§æ§à§â§ß§Ú§Ü§Ñ§Ý§î§ß§í§Û §Ô§Ú§á§à§ä§Ñ§Ý§Ñ§Þ§å§ã §Ü§Ñ§ä§Ñ§á§Ý§Ö§Ü§ã§Ú§ñ §Þ§à§ã§ä( pons) hypocretin §Á§º §Ú §¤§±
  • 9. §¸§Ú§ä§à§Ü§Ú§ß§í §Ó §â§Ö§Ô§å§Ý§ñ§è§Ú§Ú §ã§ß§Ñ 1) IL-1 NREM LPS 2) TNF NREM §¤§¿§¢ - §è§Ú§ä§à§Ü§Ú§ß§í ip, iv, icv §Ñ§ß§ä§Ñ§Ô§à§ß§Ú§ã§ä§í IL-1 §â§Ö§è§Ö§á§ä§à§â§Ñ §Ñ§ß§ä§Ú§ä§Ö§Ý§Ñ §Ü IL-1 §â§Ñ§ã§ä§Ó§à§â§Ú§Þ§í§Û IL-1 §â§Ö§è§Ö§á§ä§à§â §Õ§Ö§á§â§Ú§Ó§Ñ§è§Ú§ñ §Ú§ß§æ§Ö§Ü§è§Ú§Ú IL-1 §Ú§ß§Ô§Ú§Ò§Ú§â§à§Ó§Ñ§ß§Ú§Ö TNF §ã§ß§Ñ N. vagus
  • 10. §á§Ö§â§Ö§Õ§ß§Ú§Û §Ô§Ú§á§à- §ä§Ñ§Ý§Ñ§Þ§å§ã §¤§à§â§Þ§à§ß§í §Ó §â§Ö§Ô§å§Ý§ñ§è§Ú§Ú §ã§ß§Ñ. 1. §³§´§¤-§³§´§¤§²§¶ §ã§Ú§ã§ä§Ö§Þ§Ñ . §³§´§¤§²§¶ §°§Ò§Ý§Ñ§ã§ä§Ú §Ô§Ú§á§à§ä§Ñ§Ý§Ñ§Þ§å§ã§Ñ, §ã§à§Õ§Ö§â§Ø§Ñ§ë§Ú§Ö §³§´§¤§²§¶: 1). §¥§å§Ô§à§à§Ò§â§Ñ§Ù§ß§à§Ö §ñ§Õ§â§à 2) §¿§Ü§ã§ä§â§Ñ§Ñ§â§Ü§å§Ñ§ä§ß§í§Ö §ß§Ö§Û§â§à§ß§í §³§´§¤§²§¶ PRL (§è§Ö§ß§ä§â§Ñ§Ý§î§ß§í§Û!) icv NREM REM CT§¤ CC NREM . 2 VIP §Ú §á§â§à§Ý§Ñ§Ü§ä§Ú§ß VIP icv REM NREM §Ñ§Ü§ä§Ú§Ó§Ñ§è§Ú§ñ §â§Ö§è§Ö§á§ä§à§â§à§Ó §Ü §³§´§¤§²§¶
  • 11. §¡§Õ§Ö§ß§à§Ù§Ú§ß G A1 §Ô§Ú§á§Ö§â§á§à§Ý§ñ§â§Ú§Ù§Ñ§è§Ú§ñ §Ü§à§â§Ü§à§Ó§í§ç §ß§Ö§Û§â§à§ß§à§Ó PGD2 -§Þ§à§Õ§å§Ý§ñ§è§Ú§ñ §¡1-§â§Ö§è§Ö§á§ä§à§â§à§Ó §Ü §Ñ§Õ§Ö§ß§à§Ù§Ú§ß§å -§á§â§à§ã§ä§Ñ§Ô§Ý§Ñ§ß§Õ§Ü§Ú§ß§Ñ§Ù§Ñ D ¨C §Ó §Þ§à§Ù§Ô§à§Ó§í§ç §à§Ò§à§Ý§à§é§Ü§Ñ§ç §Ú §Ó §ç§à§â§à§Ú§Õ§ß§à§Þ §á§Ý§Ö§Ü§ã§å§ã§Ö §¬ + - §á§â§à§Ó§à§Õ§Ú§Þ§à§ã§ä§Ú 5 ¡¯-AMP 5¡¯- §ß§å§Ü§Ý§Ö§à§ä§Ú§Õ§Ñ§Ù§Ñ §Ñ§Õ§Ö§ß§à§Ù§Ú§ß
  • 12. §²§Ö§Ù§ð§Þ§Ö: §ã§à§ß §ñ§Ó§Ý§ñ§Ö§ä§ã§ñ §ã§Ý§à§Ø§ß§í§Þ §æ§Ú§Ù§Ú§à§Ý§à§Ô§Ú§é§Ö§ã§Ü§Ú§Þ §á§â§à§è§Ö§ã§ã§à§Þ, §Ù§Ñ §â§Ö§Ô§å§Ý§ñ§è§Ú§ð §Ü§à§ä§à§â§à§Ô§à §à§ä§Ó§Ö§ä§ã§ä§Ó§Ö§ß§ß§í §Þ§ß§à§Ô§Ú§Ö §à§ä§Õ§Ö§Ý§í §Þ§à§Ù§Ô§Ñ §â§Ñ§Ù§ß§í§Ö §æ§Ñ§Ù§í §ã§ß§Ñ §ç§Ñ§â§Ñ§Ü§ä§Ö§â§Ú§Ù§å§ð§ä§ã§ñ §å§Ó§Ö§Ý§Ú§é§Ö§ß§Ú§Ö§Þ §Ñ§Ü§ä§Ú§Ó§ß§à§ã§ä§Ú §Ó §à§Õ§ß§Ú§ç §à§ä§Õ§Ö§Ý§Ñ§ç §Þ§à§Ù§Ô§Ñ §Ú §å§Þ§Ö§ß§î§ê§Ö§ß§Ú§Ö§Þ §Ó §Õ§â§å§Ô§Ú§ç §Þ§ß§à§Ø§Ö§ã§ä§Ó§à §Ô§à§â§Þ§à§ß§à§Ó §Ú §Õ§â§å§Ô§Ú§ç §ï§ß§Õ§à§Ô§Ö§ß§ß§í§ç §æ§Ñ§Ü§ä§à§â§à§Ó §Ü§Ñ§Ü §Ó §ß§à§â§Þ§Ö, §ä§Ñ§Ü §Ú §á§â§Ú §á§Ñ§ä§à§Ý§à§Ô§Ú§Ú §à§Ò§Ý§Ñ§Õ§Ñ§ð§ä §ã§Ó§à§Ú§Þ §Õ§Ö§Û§ã§ä§Ó§Ú§Ö§Þ §ß§Ñ §ã§à§ß §æ§å§ß§Ü§è§Ú§Ú §ã§ß§Ñ §ä§à§é§ß§à §ß§Ö§Ú§Ù§Ó§Ö§ã§ä§ß§í
  • 13. §Þ§Ö§ß§î§ê§Ö §Ù§ß§Ñ§Ö§ê§î - §Ý§å§é§ê§Ö §ã§á§Ú§ê§î!
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