Actinomycetes are a diverse group of gram-positive filamentous bacteria that can cause actinomycosis infections in humans. Important species that cause actinomycosis include Actinomyces israelii, A. odontolyticus, A. gerencseriae, and A. meyeri. Actinomycosis is acquired endogenously, often through dental procedures or trauma, and results in abscesses, tissue destruction, and fibrosis. Clinical presentations vary by site of infection and can include cervicofacial, thoracic, pelvic, cerebral, or appendiceal/colonic infections. Diagnosis involves tissue biopsy and culture, while treatment requires a combination of