Parsek Healthcare Portal
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Genus : Plasmodium
Species : vivax
Plasmodium is one of the most harmful parasites of man.
It is a digenetic, intracellular parasite that lives in the liver cells and RBC of man. (It is extracellular in mosquito).
Its primary host is the female Anopheles mosquito and the secondary host is man. Reservoir host is monkey.
The infective stage is sickle shaped sporozoite and the mode of infection is inoculation.
Four species of Plasmodium cause four types of malaria in man.
They are
i) Plasmodium vivax benign tertian malaria
ii) Plasmodium falciparum malignant tertian malaria
iii) Plasmodium ovale mild tertian malaria
iv) Plasmodium malariae quartan malaria
Of all these four species, Plasmodium vivax is the most common and most widely distributed malaria parasite.
OBJECTIVES AND USE OF ANTIMALARIAL DRUGS
The aims of using drugs in relation to malarial infection are:
(i) To prevent clinical attack of malaria (prophylactic).
(ii) To treat clinical attack of malaria (clinical curative).
(iii) To completely eradicate the parasite from the patients body (radical curative).
(iv) To cutdown human-to-mosquito transmission (gametocidal).
These are achieved by attacking the parasite at its various stages of life cycle in the human host .
Antimalarials that act on erythrocytic schizogony are called erythrocytic schizontocides
Antimalarials that act on pre erythrocytic as well as exoerythrocytic (P. vivax) stages in liver are called tissue schizontocides,
Antimalarials which kill gametocytes in blood are called gametocides.
Severe and complicated falciparum malaria
This includes P. falciparum infection attended by any one or more of
Hyperparasitaemia,
Hyperpyrexia,
Fluid and electrolyte imbalance,
Acidosis,
Hypoglycaemia,
Prostration,
Cardiovascular collapse,
Jaundice,
Severe anaemia,
Spontaneous bleeding,
Pulmonary edema,
Haemoglobinuria,
Black water fever,
Renal failure
Cerebral malaria.
Artesunate: 2.4 mg/kg i.v. or i.m., followed by 2.4 mg/kg after 12 and 24 hours, and then once daily for 7 days. Switchover to 3 day oral ACT in between whenever the patient can take and tolerate oral medication.
or
Artemether: 3.2 mg/kg i.m. on the 1st day, followed by 1.6 mg/kg daily for 7 days. Switchover to 3 day oral ACT in between whenever the patient is able to take oral medication.
or
Arteether: 3.2 mg/kg i.m. on the 1st day, followed by 1.6 mg/kg daily for the next 4 days. Switchover to 3 day oral ACT inbetween whenever the patient is able to take oral medication.
or
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Editor's Notes
- #6: e dela gorenje gorenje preproste aparate, kaj pomeni preprosta uporabniska izkusnja na spletu