![1
JONATHAN PHAM
jmpham@umich.edu (408) 930-3458
EDUCATION
Bachelor of Science in Pharmaceutical Sciences (Honors) September 2016 May 2019
College of Pharmacy, University of Michigan, Ann Arbor, MI
Graduation with Highest Distinction (GPA >3.9/4.0)
Honors Thesis: Monoamine Oxidase Inhibitors Alter the Binding Profile of Flortaucipir ([18
F]AV-1451) A
Preclinical Evaluation of Off-Target Interactions
RESEARCH EXPERIENCE
Research Assistant September 2016 Present
Department of Radiology, Michigan Medicine, Ann Arbor, MI
Conducted assays to determine the kinetic parameters of radiotracers for imaging monoamine oxidases
Leveraged autoradiography and in vivo imaging to assess the off-target binding of radioligands used in tau-PET
Analyzed human PET/CT images supporting the clinical translation of a radiotracer for neuroendocrine tumors
Associate Radiochemist I August 2017 - Present
Department of Radiology, Michigan Medicine, Ann Arbor, MI
Manufactured F-18 (FDG, AV-1451, FEOBV) and Ga-68 (DOTATATE, PSMA-11) labelled agents for clinical use
Worked under sterile conditions and performed quality control analyses to ensure dose safety
Intern I High Throughput Biology & Screening May 2018 August 2018
Gilead Sciences, Inc., Foster City, CA
Developed an in vitro model of T cell exhaustion to evaluate combination therapies for immuno-oncology
Analyzed tumor cell lines for the expression of druggable targets (e.g. PD-L1) using flow cytometry/FACS
Supported HBV, IRAK4, and TPL2 project teams by conducting a variety of cell-based and biochemical assays
PUBLICATIONS
Drake LR*, Pham JM*, Desmond TJ, Mossine AV, Lee SJ, Kilbourn MR, Koeppe RA, Brooks AF, Scott PJH.
Identification of AV-1451 as a Weak, Nonselective Inhibitor of Monoamine Oxidase. ACS Chemical
Neuroscience, under review.
Sowa AR, Jackson IM, Desmond TJ, Alicea J, Muffareh AJ, Pham JM, Stauff J, Winton WP, Fawaz MV, Henderson
BD, Hockley BG, Rogers VE, Koeppe RA, Scott PJH. Futureproofing [18
F]Fludeoxyglucose Manufacture in an
Academic Medical Center. EJNMMI Radiopharmacy and Chemistry, 2018, 3: 12.
Drake LR, Brooks AF, Mufarreh AJ, Pham JM, Koeppe RA, Shao X, Scott PJH, Kilbourn MR. Deuterium kinetic
isotope effect studies of a potential in vivo metabolic trapping agent for Monoamine Oxidase-B. ACS
Chemical Neuroscience, 2018, 9 (12): 3024-3027.
ABSTRACTS
Drake LR, Pham JM, Desmond TJ, Brooks AF, Scott PJH. MAO-B Inhibitor Deprenyl Displaces [18
F]AV1451 binding
on human brain tissue sections and alters uptake in Nonhuman Primate Brain. Annual Meeting of the Society of
Nuclear Medicine and Molecular Imaging, Anaheim, CA, June 2019. Published J. Nucl. Med., 2019, 60: 487.
Li Y, Chan J, Ounadjela J, Pham J, Pagratis N. Establishment of 2D and 3D growth inhibition assays and a CD8+
T
cell/3D MDA-MB-231-GFP co-culture assay to evaluate oncology compounds. Society for Laboratory
Automation and Screening 2019 International Conference & Exhibition, Washington, DC, February 2019.
Drake LR, Brooks AF, Pham JM, Mossine AV, Scott PJH. [18
F]AV-1451 is a Weak Inhibitor of Monoamine Oxidase
A and B, Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Philadelphia, PA, June
2018. Published J. Nucl. Med., 2018, 59: 549.](https://image.slidesharecdn.com/phamjonathancv-190626001029/85/Pham-Jonathan_CV-1-320.jpg)
![2
Drake LR, Brooks AF, Mufarreh AJ, Pham JM, Shao X, Kilbourn MR, Scott PJH. Kinetic Isotope Effects of a 1,2,3,6-
Tetrahydropyridine-derived MAO-B substrate, Annual Meeting of the Society of Nuclear Medicine and
Molecular Imaging, Philadelphia, PA, June 2018. Published J. Nucl. Med., 2018, 59: 1026.
PRESENTATIONS
Pham JM, Drake LR, Brooks AF, Scott PJH. MAO-B Inhibitors Displace [18
F]AV-1451 Binding on Human Brain
Tissue Sections & Alter Uptake in the Nonhuman Primate Brain. Annual Meeting of the Society of
Nuclear Medicine and Molecular Imaging, Anaheim, CA, June 2019. Oral.
Pham JM, Drake LR, Desmond TJ, Brooks AF, Scott PJH. Monoamine Oxidase Inhibitors Alter the Binding Profile of
Flortaucipir ([18
F]AV-1451): A Preclinical Evaluation of Off-Target Interactions. University of Michigan
College of Pharmacy Research Forum, Ann Arbor, MI, March 2019. Poster.
Pham JM, Ounadjela JR, Chan J, Yu H, Pagratis N, Li Y, Lee G. Evaluation of T Cell Responses in in vitro Cancer
Immunotherapy Models, Gilead Sciences Biology Department Summer Intern Poster Session, Foster City, CA,
August 2018. Poster.
Pham JM, Lehnert N. D-RISE: Collaborations (and Chemistry) for College Success, 10th
Annual Michigan Pre-College
& Youth Outreach Conference, Ann Arbor, MI, November 2017. Oral.
Pham JM, Drake LR, Brooks AF, Scott PJH, Kilbourn MR. Monoamine Oxidase Activity Assays for PET
Radiotracer Development, National Conference on Undergraduate Research, Memphis, TN, April 2017. Poster.
Pham JM, Drake LR, Brooks AF, Scott PJH, Kilbourn MR. Monoamine Oxidase Activity Assays for PET
Radiotracer Development, UROP Spring Symposium, Ann Arbor, MI, April 2017. Poster.
WORK EXPERIENCE
Study Group Facilitator September 2018 May 2019
Science Learning Center, University of Michigan, Ann Arbor, MI
Contributing Writer October 2017 Present
Seeking Alpha
Accumulated >17,000 lifetime reads on articles elucidating catalysts for leading biotechnology companies
Market Research Intern August 2018 October 2018
Elazar Advisors, LLC.
Analyzed fiscal reports to create data-driven models for predicting the quarterly earnings of technology companies
Campus Advisor June 2017 August 2017
Department of Chemistry, University of Michigan, Ann Arbor, MI
Mentored disadvantaged high school students through the duration of a residential summer research program
AWARDS & RECOGNITION
University Honors September 2016 May 2019
University of Michigan, Ann Arbor, MI
James B. Angell Scholar March 2018 March 2019
University of Michigan, Ann Arbor, MI
Facilitator of the Year Physical Chemistry April 2019
Science Learning Center, University of Michigan, Ann Arbor, MI
Nominee, Distinguished Volunteer Award Student March 2019
Volunteer Services, Michigan Medicine, Ann Arbor, MI
Recipient, University of Michigan Alumni Club of Silicon Valley Scholarship July 2018
University of Michigan Alumni Association, Ann Arbor, MI
First Place, Top Long Idea of 2018 Collegiate Writing Contest March 2018
Seeking Alpha](https://image.slidesharecdn.com/phamjonathancv-190626001029/85/Pham-Jonathan_CV-2-320.jpg)
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- 1. 1 JONATHAN PHAM jmpham@umich.edu (408) 930-3458 EDUCATION Bachelor of Science in Pharmaceutical Sciences (Honors) September 2016 May 2019 College of Pharmacy, University of Michigan, Ann Arbor, MI Graduation with Highest Distinction (GPA >3.9/4.0) Honors Thesis: Monoamine Oxidase Inhibitors Alter the Binding Profile of Flortaucipir ([18 F]AV-1451) A Preclinical Evaluation of Off-Target Interactions RESEARCH EXPERIENCE Research Assistant September 2016 Present Department of Radiology, Michigan Medicine, Ann Arbor, MI Conducted assays to determine the kinetic parameters of radiotracers for imaging monoamine oxidases Leveraged autoradiography and in vivo imaging to assess the off-target binding of radioligands used in tau-PET Analyzed human PET/CT images supporting the clinical translation of a radiotracer for neuroendocrine tumors Associate Radiochemist I August 2017 - Present Department of Radiology, Michigan Medicine, Ann Arbor, MI Manufactured F-18 (FDG, AV-1451, FEOBV) and Ga-68 (DOTATATE, PSMA-11) labelled agents for clinical use Worked under sterile conditions and performed quality control analyses to ensure dose safety Intern I High Throughput Biology & Screening May 2018 August 2018 Gilead Sciences, Inc., Foster City, CA Developed an in vitro model of T cell exhaustion to evaluate combination therapies for immuno-oncology Analyzed tumor cell lines for the expression of druggable targets (e.g. PD-L1) using flow cytometry/FACS Supported HBV, IRAK4, and TPL2 project teams by conducting a variety of cell-based and biochemical assays PUBLICATIONS Drake LR*, Pham JM*, Desmond TJ, Mossine AV, Lee SJ, Kilbourn MR, Koeppe RA, Brooks AF, Scott PJH. Identification of AV-1451 as a Weak, Nonselective Inhibitor of Monoamine Oxidase. ACS Chemical Neuroscience, under review. Sowa AR, Jackson IM, Desmond TJ, Alicea J, Muffareh AJ, Pham JM, Stauff J, Winton WP, Fawaz MV, Henderson BD, Hockley BG, Rogers VE, Koeppe RA, Scott PJH. Futureproofing [18 F]Fludeoxyglucose Manufacture in an Academic Medical Center. EJNMMI Radiopharmacy and Chemistry, 2018, 3: 12. Drake LR, Brooks AF, Mufarreh AJ, Pham JM, Koeppe RA, Shao X, Scott PJH, Kilbourn MR. Deuterium kinetic isotope effect studies of a potential in vivo metabolic trapping agent for Monoamine Oxidase-B. ACS Chemical Neuroscience, 2018, 9 (12): 3024-3027. ABSTRACTS Drake LR, Pham JM, Desmond TJ, Brooks AF, Scott PJH. MAO-B Inhibitor Deprenyl Displaces [18 F]AV1451 binding on human brain tissue sections and alters uptake in Nonhuman Primate Brain. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Anaheim, CA, June 2019. Published J. Nucl. Med., 2019, 60: 487. Li Y, Chan J, Ounadjela J, Pham J, Pagratis N. Establishment of 2D and 3D growth inhibition assays and a CD8+ T cell/3D MDA-MB-231-GFP co-culture assay to evaluate oncology compounds. Society for Laboratory Automation and Screening 2019 International Conference & Exhibition, Washington, DC, February 2019. Drake LR, Brooks AF, Pham JM, Mossine AV, Scott PJH. [18 F]AV-1451 is a Weak Inhibitor of Monoamine Oxidase A and B, Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Philadelphia, PA, June 2018. Published J. Nucl. Med., 2018, 59: 549.
- 2. 2 Drake LR, Brooks AF, Mufarreh AJ, Pham JM, Shao X, Kilbourn MR, Scott PJH. Kinetic Isotope Effects of a 1,2,3,6- Tetrahydropyridine-derived MAO-B substrate, Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Philadelphia, PA, June 2018. Published J. Nucl. Med., 2018, 59: 1026. PRESENTATIONS Pham JM, Drake LR, Brooks AF, Scott PJH. MAO-B Inhibitors Displace [18 F]AV-1451 Binding on Human Brain Tissue Sections & Alter Uptake in the Nonhuman Primate Brain. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Anaheim, CA, June 2019. Oral. Pham JM, Drake LR, Desmond TJ, Brooks AF, Scott PJH. Monoamine Oxidase Inhibitors Alter the Binding Profile of Flortaucipir ([18 F]AV-1451): A Preclinical Evaluation of Off-Target Interactions. University of Michigan College of Pharmacy Research Forum, Ann Arbor, MI, March 2019. Poster. Pham JM, Ounadjela JR, Chan J, Yu H, Pagratis N, Li Y, Lee G. Evaluation of T Cell Responses in in vitro Cancer Immunotherapy Models, Gilead Sciences Biology Department Summer Intern Poster Session, Foster City, CA, August 2018. Poster. Pham JM, Lehnert N. D-RISE: Collaborations (and Chemistry) for College Success, 10th Annual Michigan Pre-College & Youth Outreach Conference, Ann Arbor, MI, November 2017. Oral. Pham JM, Drake LR, Brooks AF, Scott PJH, Kilbourn MR. Monoamine Oxidase Activity Assays for PET Radiotracer Development, National Conference on Undergraduate Research, Memphis, TN, April 2017. Poster. Pham JM, Drake LR, Brooks AF, Scott PJH, Kilbourn MR. Monoamine Oxidase Activity Assays for PET Radiotracer Development, UROP Spring Symposium, Ann Arbor, MI, April 2017. Poster. WORK EXPERIENCE Study Group Facilitator September 2018 May 2019 Science Learning Center, University of Michigan, Ann Arbor, MI Contributing Writer October 2017 Present Seeking Alpha Accumulated >17,000 lifetime reads on articles elucidating catalysts for leading biotechnology companies Market Research Intern August 2018 October 2018 Elazar Advisors, LLC. Analyzed fiscal reports to create data-driven models for predicting the quarterly earnings of technology companies Campus Advisor June 2017 August 2017 Department of Chemistry, University of Michigan, Ann Arbor, MI Mentored disadvantaged high school students through the duration of a residential summer research program AWARDS & RECOGNITION University Honors September 2016 May 2019 University of Michigan, Ann Arbor, MI James B. Angell Scholar March 2018 March 2019 University of Michigan, Ann Arbor, MI Facilitator of the Year Physical Chemistry April 2019 Science Learning Center, University of Michigan, Ann Arbor, MI Nominee, Distinguished Volunteer Award Student March 2019 Volunteer Services, Michigan Medicine, Ann Arbor, MI Recipient, University of Michigan Alumni Club of Silicon Valley Scholarship July 2018 University of Michigan Alumni Association, Ann Arbor, MI First Place, Top Long Idea of 2018 Collegiate Writing Contest March 2018 Seeking Alpha
- 3. 3 Recipient, Making a Difference Employee Recognition Award November 2017 Department of Radiology, Michigan Medicine, Ann Arbor, MI Finalist, Feinberg Family Writing Prize for Excellence in First Year Writing March 2017 Gayle Morris Sweetland Center for Writing, University of Michigan, Ann Arbor, MI PROFESSIONAL LICENSES & CERTIFICATIONS Certified Pharmacy Technician, Pharmacy Technician Certification Board August 2017 LEADERSHIP & MEMBERSHIP Treasurer, Pre-Pharmacy Student Organization May 2017 May 2019 Member, Pre-Pharmacy Student Organization September 2016 May 2019 University of Michigan, Ann Arbor, MI Member, Bachelor of Science in Pharmaceutical Sciences Curriculum Committee February 2017 Present College of Pharmacy, University of Michigan, Ann Arbor, MI Associate Member, Society of Nuclear Medicine & Molecular Imaging January 2017 Present VOLUNTEER EXPERIENCE Student Volunteer Surgery Family Waiting & Reception September 2017 Present Student Volunteer Acute Medicine June 2017 August 2017 Volunteer Services, Michigan Medicine, Ann Arbor, MI STANDARDIZED EXAMINATIONS Medical College Admissions Test April 2019 Composite Score: 522 (131/130/129/132)